Phototherapy in cancer treatment: strategies and challenges DOI Creative Commons

Yeyu Cai,

Tian Chai,

William Nguyen

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: April 2, 2025

Abstract Phototherapy has emerged as a promising modality in cancer treatment, garnering considerable attention for its minimal side effects, exceptional spatial selectivity, and optimal preservation of normal tissue function. This innovative approach primarily encompasses three distinct paradigms: Photodynamic Therapy (PDT), Photothermal (PTT), Photoimmunotherapy (PIT). Each these modalities exerts antitumor effects through unique mechanisms—specifically, the generation reactive oxygen species (ROS), heat, immune responses, respectively. However, significant challenges impede advancement clinical application phototherapy. These include inadequate ROS production rates, subpar photothermal conversion efficiency, difficulties tumor targeting, unfavorable physicochemical properties inherent to traditional phototherapeutic agents (PTs). Additionally, hypoxic microenvironment typical tumors complicates therapeutic efficacy due limited agent penetration deep-seated lesions. To address limitations, ongoing research is fervently exploring solutions. The advantages offered by nano-PTs nanocarrier systems aim enhance approaches’ effectiveness. Strategies such generating situ within or inhibiting mitochondrial respiration while targeting HIF-1α pathway may alleviate hypoxia. Moreover, utilizing self-luminescent materials, near-infrared excitation sources, non-photoactivated sensitizers, wireless light delivery can improve penetration. Furthermore, integrating immunoadjuvants modulating immunosuppressive cell populations deploying checkpoint inhibitors holds promise enhancing immunogenic death PIT. review seeks elucidate fundamental principles biological implications phototherapy discussing dominant mechanisms advanced strategies designed overcome existing challenges—ultimately illuminating pathways future aimed at amplifying this intervention’s efficacy.

Language: Английский

Fabrication of Gemcitabine and Mitoxantrone Loaded PLG/Mesoporous Silica Nanofibers: Investigation of In Vitro Drug Release and Anticancer Activity in Pancreatic Cancer Cells DOI
Huimin Wu,

Sheng-lan Wang,

Xinxing Li

et al.

BioNanoScience, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 3, 2025

Language: Английский

Citations

2
Hollow mesoporous silica nanoparticles for drug formulation and delivery: opportunities for cancer therapy DOI
Huiqi Guo, Xia Zhao,

Yanping Duan

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: unknown, P. 114534 - 114534

Published: Jan. 1, 2025

Language: Английский

Citations

2
Advances of Photothermal Agents with Fluorescence Imaging/Enhancement Ability in the Field of Photothermal Therapy and Diagnosis DOI
Siyi Yuan, Jun Zhou, Ao Wang

et al.

Molecular Pharmaceutics, Journal Year: 2024, Volume and Issue: 21(2), P. 467 - 480

Published: Jan. 24, 2024

Photothermal therapy (PTT) is an effective cancer treatment method. Due to its easy focusing and tunability of the irradiation light, direct accurate local can be performed in a noninvasive manner by PTT. This strategy requires use photothermal agents convert light energy into heat energy, thereby achieving heating triggering biochemical processes kill tumor cells. As key factor PTT, conversion ability directly determines efficacy In addition, generally have imaging (PTI) photoacoustic (PAI) functions, which not only guide optimization conditions but also achieve integration disease diagnosis. If function fluorescence (FLI) or enhancement, they further improve accuracy diagnosis accurately determine location through multimodal for corresponding treatment. this paper, we summarize recent advances with FLI enhancement functions PTT According different recognition sites, application specific targeting introduced. Finally, limitations challenges imaging/enhancement field are prospected.

Language: Английский

Citations

10
Cu-TCPP Metal–Organic Nanosheets Embedded Thin-Film Composite Membranes for Enhanced Cyanide Detection and Removal: A Multifunctional Approach to Water Treatment and Environmental Safety DOI Creative Commons
Upendar Reddy Gandra, Ravi P. Pandey,

L. Palanikumar

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 2, 2025

Cyanide is highly toxic, with widespread industrial use posing serious environmental risks. Effective materials for detecting and filtering cyanide from water are urgently needed. This study introduces a novel approach utilizing Cu-TCPP (TCPP = o-tetra(4-carboxyphenyl)porphine) metal-organic nanosheets (MONS) embedded in thin-film composite membranes, offering multifunctional solution detection filtration. Ultrathin MONs were synthesized using surfactant-assisted method featuring accessible metal centers that enhance interaction detection. The developed by modifying cellulose acetate (CA) MONs, demonstrated exceptional performance removal. 6% Cu-TCPP/CA membrane exhibited 2.3-fold increase pure permeability achieved removal efficiency of 94.68%, significantly outperforming the pristine 0% (Pure Water Permeability (PWP) 380.83 L m-2 h-1 bar-1; CN- 5.01%). first report describing technique literature. In addition to its efficiency, showed remarkable capabilities, calculated limit 1.76 × 10-7 M, surpassing World Health Organization (WHO) United States Environmental Protection Agency (EPA) safety standards levels water. Additionally, bioimaging agent excellent cell viability, deployed detect MiaPaCa-2 cells, concentrations as low 0.1 ppm.

Language: Английский

Citations

1
Advancements in pH-responsive nanocarriers: enhancing drug delivery for tumor therapy DOI

Zhouyun Chen,

Xiaoxiao Wang, Na Zhao

et al.

Expert Opinion on Drug Delivery, Journal Year: 2023, Volume and Issue: 20(11), P. 1623 - 1642

Published: Nov. 2, 2023

Tumors pose a significant global economic and health burden, with conventional cancer treatments lacking tumor specificity, leading to limited efficiency undesirable side effects. Targeted therapy is imminent. Tumor cells produce lactate hydrogen ions (H

Language: Английский

Citations

20
Two birds with one stone: A multi-functional nanoplatform for sensitive detection and real-time inactivation of pathogenic bacteria with NIR-triggered PTT/PDT DOI
Xianqing Huang, Yana Fu, Yicheng Guo

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 481, P. 148649 - 148649

Published: Jan. 8, 2024

Language: Английский

Citations

7
Fabrication of folic acid-modified bovine serum albumin cloaked dual-drug loaded hollow mesoporous silica nanoparticles for pH-responsive and targeted delivery of gastric cancer therapy DOI Creative Commons
Yuan‐Wei Zhang,

Yuanxiao Liang

Heliyon, Journal Year: 2024, Volume and Issue: 10(8), P. e29274 - e29274

Published: April 1, 2024

Combination therapy is a highly successful way to address the limitations of using single treatment method and improve therapy's overall efficacy. In this study, we developed unique hollow mesoporous silica nanoparticle (HMSN) coated with folic acid (FA)-modified bovine serum albumin (FA-BSA). This nanoparticle, referred as HFB, was designed target cancer cells release dual therapeutic drugs, Indocyanine green (ICG) Paclitaxel (PTX), in response specific stimuli termed HFB@IP. The BSA protein acts "gatekeeper" prevent early drug releases cargo leakage by detaching from reaction GSH. FA facilitates targeted transport into that express folate receptors (FR), enhancing effectiveness chemo-photodynamic (PDT). nanocarrier demonstrated vitro pH/redox-triggered HFB@IP due breaking imine bonds between aldehyde-functionalized HMSN (CHO-HMSN) FA-BSA disulfide bond inside BSA. addition, various biological assessments, including cell uptake experiments, effectively targets SGC-7901 induces apoptosis vitro. Further, it exhibits remarkable efficiency synergistically killing through therapy, indicated combination index (CI) 0.328. results showed combining biodegradable stimuli-responsive molecules could offer promising approach for precise treating gastric cancer, allowing controlled drugs necessary.

Language: Английский

Citations

6
Engineering of phytic acid-coated Prussian nanoparticles for combined Nitric oxide and Low-Temperature photothermal therapy of osteosarcoma DOI
Ye Zhang, Hai Mou, Qiu Huang

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 491, P. 151730 - 151730

Published: April 27, 2024

Language: Английский

Citations

6
Construction of Circular Polarized Luminescence Molecules for Intense Near Infrared OLEDs DOI

Ning Liang,

Jianxun Liu,

Yufan Lin

et al.

Advanced Optical Materials, Journal Year: 2024, Volume and Issue: 12(16)

Published: March 14, 2024

Abstract The exploration of organic near‐infrared (NIR) luminescence, along with circularly polarized luminescence (CPL), is vital importance due to its significance in medical and optoelectronic applications. Integrating a chiral unit into D–A molecular structure this research realized emission peaks at 744 nm, exhibiting dissymmetric factor −1.67 × 10 −3 . introduced TPA derivative not only imparts aggregation‐induced properties CPL capabilities but also induces redshift the spectrum. Consequently, fabricated NIR light‐emitting devices (OLEDs), achieve maximum electroluminescent 748 nm nondoped external quantum efficiency 13.7% doped devices. This pioneering provides inspiration for design molecules possessing future, particularly promoting application intense NIR‐OLEDs.

Language: Английский

Citations

6
A pH-responsive nanoplatform with dual-modality imaging for enhanced cancer phototherapy and diagnosis of lung metastasis DOI Creative Commons
Mujie Yuan, Zeyu Han, Yan Li

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: April 15, 2024

Abstract To address the limitations of traditional photothermal therapy (PTT)/ photodynamic (PDT) and real-time cancer metastasis detection, a pH-responsive nanoplatform (NP) with dual-modality imaging capability was rationally designed. Herein, 1 H,1 H-undecafluorohexylamine (PFC), served as both an oxygen carrier 19 F magnetic resonance (MRI) probe, photosensitizer indocyanine green (ICG) were grafted onto peptide hexahistidine (H 6 ) to form H -PFC-ICG (HPI). Subsequently, heat shock protein 90 inhibitor, gambogic acid (GA), incorporated into hyaluronic (HA) modified HPI (HHPI), yielding ultimate HHPI@GA NPs. Upon self-assembly, NPs passively accumulated in tumor tissues, facilitating release HA-mediated cell uptake. Once phagocytosed by lysosomes, protonation triggered due low pH, resulting GA. With near-infrared laser irradiation, GA-mediated decreased HSP90 expression PFC-mediated increased ROS generation amplified PTT/PDT effect HHPI@GA, leading excellent vitro vivo anticancer efficacies. Additionally, fluorescence MRI dual-imaging capabilities enabled effective primary lung monitoring. This work offers novel approach for enhanced phototherapy, well precise diagnosis.

Language: Английский

Citations

6