Med-X, Journal Year: 2024, Volume and Issue: 2(1)
Published: Oct. 1, 2024
Language: Английский
Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101557 - 101557
Published: Feb. 5, 2025
Diabetic infections/wounds remain to be a threatening challenge as it seriously leads lower limb amputation with endless pains and subsequent high economic/psychosocial costs. The exceptional peroxidase-like activity of single-atom nanozymes (SAzymes) holds great promise for chemodynamic therapy (CDT) diabetic infection, but is extremely restricted by the near-neutral pH insufficient H2O2 levels in physiological conditions. Herein, we innovated hollow mesoporous molybdenum nanozyme (HMMo-zyme) featured catalytic activity, photothermal performance drug delivery properties more effective antibacterial therapeutic glucose oxidase (GOx) was encapsulated into HMMo-zyme phase-change material (PCM) form HMMo/GOx@P system, which could controllably disassembled near-infrared ray (NIR) trigger cascade CDT toward bacterial infections. results revealed that release GOx accelerated NIR facilitate continuous conversion (Glu) gluconic acid, accompanied sharply decrease establish low-pH environment notably enhanced HMMo-zyme, subsequently drives generated toxic hydroxyl radicals (·OH) amplified anti-bacterial treatment. As proof concept, this NIR-assisted strategy efficiently inhibit/kill bacteria suppress tissue inflammations, thereby accelerating wound healing processes both vitro vivo infection models. This study provides novel may serve promising alternative antibiotic therapeutics against thus holding treatment manipulating Mo-based SAzymes.
Language: Английский
Citations
0
Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 10, 2025
Abstract The skin microenvironment is a highly intricate and dynamic system, characterized by an acidic pH, diverse microbiota, various metabolites, numerous enzymes, creating both challenges opportunities for the development of innovative drug delivery systems. Dissolving Microneedles (MNs) have emerged as promising, pain‐free alternative to conventional invasive injections, offering ability deliver therapeutics through gradual degradation within skin's interstitial fluids. Building upon unique properties dissolving MNs, novel concept introduced wherein MNs serve in situ chemical reaction chambers. In this framework, can reactants or catalysts skin, enabling initiation specific reactions, such prodrug activation targeted therapy, harmful enhanced synthesis beneficial molecules. Moreover, review systematically explores potential chambers, discussing key aspects their sustained release mechanisms, design strategies, range therapeutic applications. Finally, forward‐looking perspective provided on future addressing broader clinical translation application personalized medicine.
Language: Английский
Citations
0
Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2025, Volume and Issue: 334, P. 125957 - 125957
Published: Feb. 26, 2025
Language: Английский
Citations
0
TrAC Trends in Analytical Chemistry, Journal Year: 2025, Volume and Issue: 187, P. 118208 - 118208
Published: Feb. 27, 2025
Language: Английский
Citations
0
Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 26, 2025
Abstract Driven by the growing burden of chronic diseases and limited public healthcare resources, portable health monitoring platforms are widely developed to enable continuous timely dissemination provide users with management disease prevention. However, it is still a challenge for precision fully bio‐integrated electronic devices achieve stable physiological signal recording over long periods time. Recently, semi‐implantable bioelectronics (SI‐bioelectronics) have excelled in real‐time, long‐term, high‐sensitivity pathological signals minimal invasiveness, enabled precise microneedle sensing probes. In this review, comprehensive overview recent advancements SI‐bioelectronics provided, focus on their structures, design considerations, performances biochemical indicators, bioelectrical signals, biomechanical signals. Opportunities research such as smart medicine Internet Things also discussed, which will drive toward intelligence efficiency.
Language: Английский
Citations
0
Small Methods, Journal Year: 2025, Volume and Issue: unknown
Published: March 17, 2025
Abstract Traditional ophthalmic formulations are characterized by low bioavailability, short intraocular retention time, strong irritation, and failure to achieve the expected therapeutic effect due special physiological structure of eye existence many barriers. Microneedle drug delivery is a novel transdermal modality. Responsive microneedles defined as controllably releasing payloads in response stimuli, including pH levels, temperature, enzymes, reactive oxygen species (ROS), well external stimuli such magnetic fields light. In addition inheriting advantages traditional microneedles, which include enhanced targeting permeability, non‐invasiveness, painless application, integration with stimulus‐responsive materials enables responsive personalized precision process, further increases accuracy efficiency ocular treatments, making on‐demand possible. This article systematically reviews classification, mechanisms, characteristics provides detailed introduction their diagnostic applications real‐time monitoring potential diseases, aiming offer insights for treatment diseases future.
Language: Английский
Citations
0
ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown
Published: April 12, 2025
Language: Английский
Citations
0
Advanced Science, Journal Year: 2025, Volume and Issue: unknown
Published: April 24, 2025
Abstract This study presents a novel method to control the site‐selective growth of Au nanostars on CuS nanodisc substrate, it indicates that surfactant ligands play key role in architecture control, only CTAC and homologous series with appropriate affinity can direct annular‐epitaxial nanoparticles CuS, which demonstrates superior peroxidase (POD)‐mimic SERS activity. Mechanistic studies indicate plasmon‐enhanced catalytic activity be attributed spatially separated CuS‐Au heterostructure, supports light‐triggered hot electron‐hole pairs production localized surface plasmon resonance hotspots. For practical biosensing, heterostructures assembled lateral flow assay (LFA) was used for SERS/catalytic colorimetric/photothermal three‐mode detection Streptococcus pneumoniae Klebsiella , visually colorimetric mode at 103 CFU/mL quantitative SERS/photothermal modes 2–10 2 within 15 min, clinical samples were validate assay, result 100% concordant results real‐time PCR. provides unique avenue controllably produce nanozyme, provide multi‐mode signals LFA application meet requirements different scenarios.
Language: Английский
Citations
0
Analytica Chimica Acta, Journal Year: 2025, Volume and Issue: unknown, P. 344149 - 344149
Published: May 1, 2025
Language: Английский
Citations
0
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 156130 - 156130
Published: Sept. 1, 2024
Language: Английский
Citations
3