Nano-Micro Letters,
Journal Year:
2025,
Volume and Issue:
17(1)
Published: May 12, 2025
Abstract
Single-atom
nanozymes
(SAzymes)
hold
significant
potential
for
tumor
catalytic
therapy,
but
their
effectiveness
is
often
compromised
by
low
efficiency
within
microenvironment.
This
mainly
influenced
key
factors
including
hydrogen
peroxide
(H
2
O
)
availability,
acidity,
and
temperature.
Simultaneous
optimization
of
these
presents
a
challenge
therapy.
In
this
study,
we
developed
comprehensive
strategy
to
refine
single-atom
kinetics
enhancing
therapy
through
dual-enzyme-driven
cascade
reactions.
Iridium
(Ir)
SAzymes
with
high
activity
natural
enzyme
glucose
oxidase
(GOx)
were
utilized
construct
the
reaction
system.
GOx
was
loaded
Ir
due
its
large
surface
area.
Then,
system
modified
cancer
cell
membranes
improving
biocompatibility
achieving
homologous
targeting
ability.
catalysis
could
produce
abundant
H
lower
local
pH,
thereby
optimizing
reaction-limiting
factors.
Additionally,
upon
laser
irradiation,
raise
temperature,
further
dual-enzyme
maximized
performance
SAzymes,
significantly
Our
findings
present
refining
homologous-targeted
Angewandte Chemie,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 9, 2025
Abstract
Albumin‐based
drug
delivery
system,
exemplified
by
FDA‐approved
treatments
like
Abraxane,
have
demonstrated
significant
potential
in
cancer
therapy.
However,
albumin
carriers
still
suffer
from
poor
tumor‐targeting
capability,
leading
to
low
efficacy
and
systemic
side
effects
on
healthy
cells
applications.
Here,
we
report
a
general
method
for
modification
of
drugs
aptamer
coating
shell
that
are
hydrophobically
inserted
into
the
surface,
constructing
drugs‐cored
spherical
nucleic
acid
(adSNA).
This
adSNA
platform
allows
versatile
loading
various
therapeutic
agents,
including
chemotherapy
drugs,
polyphenols,
cuproptosis
inducers,
near‐infrared
(NIR)
photosensitizers,
enabling
targeted
tumor
delivery.
Compared
with
covalent
method,
hydrophobic
insertion
has
been
proven
be
greater
simplicity,
higher
aptamer‐grafting
efficiency,
superior
capabilities,
comparable
stability
under
physiological
conditions.
In
proof‐of‐concept
study,
delivered
NIR‐II
photothermal
agents
heat
shock
protein
inhibitors
tumor‐specific
mild
traditional
therapy
(PTT),
this
approach
utilizes
PTT
achieve
tissue
penetration
while
downregulating
proteins
cells,
resulting
precise
thermal
ablation
at
lower
temperatures.
addition,
adSNAs
straightforward
synthesize
scalable
large‐scale
production,
offering
advance
development
clinical
drugs.
ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 9, 2025
Inspired
by
the
clinical
application
of
thermotherapy
to
promote
efficacy
radiotherapy,
this
study
demonstrates
multimodal
diagnostic
pure
organic
nanoparticles
in
combined
treatment
tumors
through
imaging
and
photothermal
properties.
The
developed
demonstrated
unique
properties
multiple
functionalities,
including
excellent
photostability
thermostability,
strong
fluorescence
emission
near-infrared-II
(NIR-II)
region,
extremely
high
conversion
efficiency,
good
biocompatibility,
significant
radiosensitizing
properties,
effective
tumor
site
accumulation.
In
vitro
vivo
evaluations
that
these
are
ideal
candidates
for
synergistic
radiotherapy
guided
NIR-II
fluorescence,
NIR-I
photoacoustic,
trimodal
imaging.
They
act
as
radiosensitizers
alleviating
hypoxic
microenvironment,
modulating
cell
cycle,
inducing
apoptosis
immunogenic
death
during
which
may
provide
a
potential
approach
tumors.
ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 8, 2025
The
development
of
new
CRISPR/Cas9
delivery
systems
with
a
synergistic
therapeutic
mode
can
provide
perspective
for
efficient
tumor
treatment.
In
this
work,
we
developed
bionic
2D
FeS
nanoplatform
high
loading
(FCRM),
highlighting
the
synergy
and
ferroptosis
in
regulating
heat
shock
proteins
(HSPs)
enhanced
photothermal
therapy
(PTT).
Due
to
ultrathin
structure
pH-response
nanosheets,
FCRM
quickly
decompose
microenvironment
effectively
release
Fe2+,
which
be
further
by
process.
accurately
downregulate
level
intracellular
antiapoptosis
protein
Survivin.
Fe2+
induce
lipid
peroxidation
cells.
Ferroptosis
regulation
Survivin
synergistically
expression
HSPs,
thereby
reducing
resistance
cells
PTT.
Additionally,
caused
significant
magnetic
resonance
contrast
enhancement,
aided
accurate
diagnosis
tumors.
Therefore,
has
great
potential
achieving
targeted
imaging
dual
HSPs
ferroptosis-gene
Nano-Micro Letters,
Journal Year:
2025,
Volume and Issue:
17(1)
Published: May 12, 2025
Abstract
Single-atom
nanozymes
(SAzymes)
hold
significant
potential
for
tumor
catalytic
therapy,
but
their
effectiveness
is
often
compromised
by
low
efficiency
within
microenvironment.
This
mainly
influenced
key
factors
including
hydrogen
peroxide
(H
2
O
)
availability,
acidity,
and
temperature.
Simultaneous
optimization
of
these
presents
a
challenge
therapy.
In
this
study,
we
developed
comprehensive
strategy
to
refine
single-atom
kinetics
enhancing
therapy
through
dual-enzyme-driven
cascade
reactions.
Iridium
(Ir)
SAzymes
with
high
activity
natural
enzyme
glucose
oxidase
(GOx)
were
utilized
construct
the
reaction
system.
GOx
was
loaded
Ir
due
its
large
surface
area.
Then,
system
modified
cancer
cell
membranes
improving
biocompatibility
achieving
homologous
targeting
ability.
catalysis
could
produce
abundant
H
lower
local
pH,
thereby
optimizing
reaction-limiting
factors.
Additionally,
upon
laser
irradiation,
raise
temperature,
further
dual-enzyme
maximized
performance
SAzymes,
significantly
Our
findings
present
refining
homologous-targeted
