ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(12), P. 14503 - 14509
Published: March 18, 2024
The
activation
of
proinflammatory
M1-type
macrophages
in
the
injured
lesion
accelerates
progression
a
spinal
cord
injury
(SCI).
However,
adverse
side
effects
during
systemic
treatments
targeting
M1
have
limited
their
applications.
Nanoplatforms
are
novel
carriers
traditional
Chinese
medicine
because
great
efficiency
to
deliver
and
accumulation
lesion.
Herein,
we
synthesized
modified
zeolitic
imidazolate
framework-8
(ZIF-8)
nanoplatform
for
internalization
effective
administration
SCI.
In
vitro
vivo
experiments
suggested
that
Prussian
blue
Schisandrin
B
ZIF-8
effectively
accumulated
macrophages,
inhibited
reactive
oxygen
species
(ROS),
polarized
macrophage
from
anti-inflammatory
M2
rapid
tissue
infiltration
by
reprogramming
metabolic
phenotype.
This
achieves
synergistic
therapeutic
effect
immunomodulation
neuroprotection,
thereby
shedding
new
light
on
application
ZIF-8,
provides
potential
Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 4, 2025
Abstract
Inflammation
is
essential
for
pathogen
eradication
and
tissue
repair;
However,
chronic
inflammation
can
bring
on
multi‐organ
dysfunction
due
to
an
overproduction
of
reactive
oxygen
species
(ROS).
Among
various
anti‐inflammatory
agents,
polyphenol‐based
nanotherapeutics
offer
potential
advantages,
including
enhanced
stability,
targeted
delivery,
multiple
therapeutic
functions,
personalized
therapy
tailored
the
severity.
Despite
these
development
biocompatible
nanomedicines
capable
selective
accumulation
in
inflamed
tissues
efficient
inhibition
ROS‐induced
inflammatory
signaling
pathways
remains
a
considerable
challenge.
In
this
study,
novel
nanotherapeutic
engineered
through
temperature‐dependent
condensation
polyphenolic
catechin
facilitated
by
hydrothermal
reactions.
The
resulting
catechin‐condensed
(CCN150),
synthesized
at
relatively
low
temperature,
retains
physicochemical
functional
properties
akin
its
precursor,
catechin,
but
with
marked
enhancement
water
solubility.
CCN150
protects
cells
from
oxidative
stress
eliminating
intracellular
ROS
augmenting
antioxidant
enzymes.
vivo
studies
reveal
that
intravenously
administered
predominantly
accumulates
tissues,
minimal
distribution
healthy
regions.
Furthermore,
effectively
reduces
systemic
mouse
models
disrupting
cycles
instigated
pro‐inflammatory
milieu.
Exhibiting
negligible
toxicity,
holds
substantial
promise
extensive
applications
treatment
ROS‐mediated
diseases.
Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 1, 2025
Abstract
Hemophilic
arthropathy
(HA),
a
form
of
arthritis
associated
with
joint
bleeding,
presents
extra
challenges
in
treatment
due
to
intermittent
bleeding‐induced
iron‐overloading,
oxidative
stress,
and
inflammation.
Conventional
therapeutic
approaches
have
predominantly
concentrated
on
achieving
hemostasis
reducing
inflammation,
yet
they
fallen
short
effectively
managing
iron
overload
safeguarding
cartilage,
resulting
less‐than‐ideal
outcomes.
To
address
these
issues,
series
injectable
hydrogels
is
facilely
fabricated
via
one‐step
assembly
polyphenols,
chelators,
lipoic
acid.
In
vitro
investigations
demonstrate
that
the
not
only
good
performances
antioxidation
anti‐inflammation,
but
also
exhibit
promising
prospects
removal,
adhesion
resistance,
wear
resistance.
Moreover,
vivo
studies
are
further
carried
out
indicate
diminished
inflammatory
response,
ameliorative
iron‐overload‐related
lesion
indicators,
cartilage
preservation.
This
class
robust
multifunctional
composed
clinically
available
drugs
along
commonly
used
commercial
ingredients
would
offer
new
opportunities
toward
efficient
HA.
ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(12), P. 14503 - 14509
Published: March 18, 2024
The
activation
of
proinflammatory
M1-type
macrophages
in
the
injured
lesion
accelerates
progression
a
spinal
cord
injury
(SCI).
However,
adverse
side
effects
during
systemic
treatments
targeting
M1
have
limited
their
applications.
Nanoplatforms
are
novel
carriers
traditional
Chinese
medicine
because
great
efficiency
to
deliver
and
accumulation
lesion.
Herein,
we
synthesized
modified
zeolitic
imidazolate
framework-8
(ZIF-8)
nanoplatform
for
internalization
effective
administration
SCI.
In
vitro
vivo
experiments
suggested
that
Prussian
blue
Schisandrin
B
ZIF-8
effectively
accumulated
macrophages,
inhibited
reactive
oxygen
species
(ROS),
polarized
macrophage
from
anti-inflammatory
M2
rapid
tissue
infiltration
by
reprogramming
metabolic
phenotype.
This
achieves
synergistic
therapeutic
effect
immunomodulation
neuroprotection,
thereby
shedding
new
light
on
application
ZIF-8,
provides
potential
