Nanoscale,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Esophageal
squamous
cell
carcinoma
(ESCC)
is
an
aggressive
malignancy
characterized
by
limited
treatment
options
and
poor
prognosis.
Nanoparticle-based
drug
delivery
systems
have
emerged
as
a
promising
strategy
to
enhance
cancer
therapy
efficacy
improving
targeting,
reducing
toxicity,
enabling
multifunctional
applications.
This
review
highlights
some
key
types
of
nanoparticles,
including
liposomes,
polymeric
metallic
dendrimers,
quantum
dots,
which
could
effectively
improve
the
various
drugs
used
in
chemotherapy,
radiotherapy,
immunotherapy,
offering
more
precise
effective
options.
With
ability
stability
overcome
biological
barriers,
nanoparticle-based
represent
transformative
for
ESCC
treatment.
Despite
challenges,
such
biocompatibility
scalability,
future
holds
great
promise,
particularly
development
personalized
nanomedicine
novel
therapeutic
approaches
targeting
tumor
microenvironment.
ongoing
advancements,
hold
immense
potential
revolutionize
patient
outcomes.
Biomaterials Science,
Journal Year:
2024,
Volume and Issue:
12(18), P. 4607 - 4629
Published: Jan. 1, 2024
The
combination
of
chemodynamic
therapy
(CDT)
with
immunotherapy
can
result
in
enhanced
therapeutic
effects
cancers.
recent
progresses
and
challenges
concerning
nanomedicine
for
CDT
are
summarized
discussed.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 5, 2024
Abstract
Chemical
reactions
underpin
biological
processes,
and
imbalances
in
critical
biochemical
pathways
within
organisms
can
lead
to
the
onset
of
severe
diseases.
Within
this
context,
emerging
field
“Nanocatalytic
Medicine”
leverages
nanomaterials
as
catalysts
modulate
fundamental
chemical
specific
microenvironments
This
approach
is
designed
facilitate
targeted
synthesis
localized
accumulation
therapeutic
agents,
thus
enhancing
treatment
efficacy
precision
while
simultaneously
reducing
systemic
side
effects.
The
effectiveness
these
nanocatalytic
strategies
critically
hinges
on
a
profound
understanding
kinetics
intricate
interplay
particular
pathological
ensure
effective
catalytic
actions.
review
methodically
explores
situ
their
associated
biomaterials,
emphasizing
regulatory
that
control
responses.
Furthermore,
discussion
encapsulates
crucial
elements‐reactants,
catalysts,
reaction
conditions/environments‐necessary
for
optimizing
thermodynamics
reactions,
rigorously
addressing
both
biophysical
dimensions
disease
enhance
outcomes.
It
seeks
clarify
mechanisms
underpinning
biomaterials
evaluate
potential
revolutionize
across
various
conditions.
Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 21, 2025
Abstract
Tumor
cells
exploit
abnormal
redox
homeostasis
and
the
pro‐tumorigenic
effect
of
reactive
oxygen
species
(ROS)
to
enhance
their
survival
progression.
However,
excessively
high
levels
ROS
can
exceed
oxidative
stress
threshold
tumor
cells,
inducing
cell
death.
This
occur
by
selectively
elevating
concentration
H
2
O
in
through
both
endogenous
exogenous
mechanisms.
The
generated
serves
as
a
precursor
for
toxic
ROS,
such
•
OH
1
,
via
chemodynamic
photodynamic
therapy,
respectively,
leading
apoptosis,
necrosis,
ferroptosis.
Strategies
boost
include
direct
delivery
amplifying
generation
inhibiting
antioxidant
enzymes,
leveraging
glucose
oxidase,
employing
photocatalytic
therapy
(PCT),
utilizing
metal
peroxides.
Among
them,
peroxides
have
displayed
remarkable
performance
due
excellent
potential
elevate
within
while
simultaneously
normalizing
acidic
hypoxic
conditions
microenvironment
(TME).
Moreover,
these
nanostructures
sensitivity
complementary
treatments,
like
chemotherapy.
review
summarizes
advanced
perspectives
design,
synthesis,
comparative
analysis
‐generating
nanoplatforms,
emphasizing
capacity
treat
various
cancers.
Nanoscale,
Journal Year:
2024,
Volume and Issue:
16(21), P. 10208 - 10220
Published: Jan. 1, 2024
Dendrimers
and
dendritic
NPs
are
emerging
as
potential
nanoplatforms
for
cancer
immunotherapy.
This
minireview
provides
an
updated
overview
of
dendrimer
conjugates,
hybrids,
dendron-based
copolymers
targeted
therapy.
Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 6, 2025
Glucose
oxidase
(GOX)-induced
starvation
is
a
safe
treatment
for
tumor.
However,
the
non-specific
targeting
of
GOX
and
plasticity
tumor
metabolism
lead
to
toxic
side
effects
low
mortality.
Thus,
it
necessary
develop
synergistic
strategy
with
high
specificity
enhance
mortality
GOX.
In
this
study,
genetically
engineered
CD44
peptide
(CP)
IL-21
fusion
protein-displaying
nanovesicles
platform
(mCP@IL21-Fc-GOX)
are
designed
efficiently
encapsulate
ferrocene
(Fc).
After
reaching
site,
can
be
precisely
released
targeted
NK
cells
through
cleavage
MMP-2,
thus
achieving
precise
anti-tumor
immunotherapy
IL-21.
Second,
exposed
CP
enable
mCP-Fc-GOX
further
cells,
completing
anti-cancer
chemodynamic
therapy
(CDT)
triggered
by
Fc.
situ
breast
cancer
models,
results
show
that
mCP@IL21-Fc-GOX
not
only
enhances
T
aggregation
in
tissue
but
also
achieves
nutrition
deprivation
abundant
reactive
oxygen
species
production,
significantly
inhibits
growth
based
on
function
immunotherapy,
CDT.
Therefore,
work
provides
smart
nanovesicle
therapy.
