Rational Design of Bio‐Inspired Peptide Electronic Materials toward Bionanotechnology: Strategies and Applications

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(29)

Published: March 18, 2024

Abstract Biologically inspired peptide‐based materials, as novel charge transport have gained increasing interest in bioelectronics due to their remarkable electrical properties and inherent biocompatibility. Extensive studies shown that peptides can self‐assemble into a variety of hierarchical nanostructures with unique physical through supramolecular interactions. Therefore, materials hold great promise for applications emerging electronic fields such sensing, energy harvesting, storage, transmission. Herein, this work proposes review article summarize the rational design research progress devices bioelectronics. This first introduces strategies assembly mechanism constructing high‐performance devices. In following part, are systematically classified discussed, including sensors, piezoelectric nanogenerators, electrodes, semiconductors. Finally, remaining challenges future perspectives bioelectronic presented. believes will provide inspiration guidance development innovative smart field

Language: Английский

---

Supramolecular Gelation Based on Native Amino Acid Tyrosine and Its Charge-Transfer Complex Formation

Langmuir, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

Self-assembly of amino acids and short-peptide derivatives attracted significant curiosity worldwide due to their unique self-assembly process wide variety applications. Amino acid is considered one the important synthons in supramolecular chemistry. processes applications unfunctionalized native have been less reported literature. In this article, we are first-time reporting tyrosine (Tyr), an aromatic acid, dimethyl sulfoxide (DMSO) solvent. Most studies related Tyr were different aqueous solutions. our work, studied several common organic solvents found that could self-assemble into a gel The was investigated by techniques, such as UV-vis, fluorescence, FTIR, NMR spectroscopy. Morphological features on nanoscale through scanning electron microscopy (SEM). SEM images indicated formation nanofibrils with high aspect ratios. property rheological experiments. Computational study DMSO medium suggested noncovalent interactions like hydrogen bonding π-π stacking among molecules played prominent role. Finally, charge-transfer complex ability electron-rich electron-deficient 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) studied. presence DDQ formation, converted reddish color solution, fibrillar morphologies collapsed.

Language: Английский

---

Piezoelectric Vitamin‐Based Self‐Assemblies for Energy Generation

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

Abstract Structural diversity of biomolecules leads to various supramolecular organizations and asymmetric architectures self‐assemblies with significant piezoelectric response. However, the piezoelectricity biomolecular has not been fully explored relationship between structures remains poorly understood, which hinders development biomaterials. Herein, for first time, vitamin‐based power generation is systematically explored. X‐ray diffraction studies revealed that vitamin molecules can self‐assemble into different structures, exhibited tunable coefficients ranging from 3.8 42.8 pC N −1 by density functional theory (DFT) calculations. Notably, B 7 D‐biotin (D‐BIO) superior due low crystal symmetry high polarization arrangements. The D‐BIO assemblies‐based nanogenerator (PENG) produced output voltages ≈0.8 V under a mechanical force 47 N, showing durability after 5400 pressing‐releasing cycles stability at least three months. PENG‐based wearable sensor successfully detected bending motions human limbs. Furthermore, insole converted biomechanical energy stable electrical upon foot movement, illuminating 12 light‐emitting diodes (LEDs). This work fills knowledge gaps in self‐assemblies, providing paradigms realizing high‐performance biomaterials through engineering.

Language: Английский

---

Tradeoff between Mechanical Strength and Electrical Conductivity of MXene Films by Nacre‐Inspired Subtractive Manufacturing

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 12, 2025

Abstract Traditional strategies, by additive manufacturing, for integrating monolayer Ti 3 C 2 T x nanosheets into macroscopic films with binders can effectively improve their mechanical strength, but the electrical conductivity is often sacrificed. Herein, inspired aligned nano‐compacted feature of nacre, a flexible subtractive manufacturing strategy reported to squeeze interlayer 2D spacings removing nanoconfined water and interface terminations, leading improvement strength stability layered without sacrificing conductivity. After vacuum annealing at 300 °C (A300), spacing decreased ≈0.1 nm surface functional groups (═O, ─OH, ─F) molecules greatly removed. The tensile (95.59 MPa) Young's modulus (9.59 GPa) A300 are ≈3 ≈2 times improved, respectively. Moreover, maintain metallic (2276 S cm −1 ) show enhanced stability. Compared original films, increasing friction energy dissipation decrease spacings. This work provides new way engineering self‐assembled more functions broad applications.

Language: Английский

---

Tailored Fibrils Approach via Ag(I).Peptidomimetic-Based Interface Design: Efficient Encapsulation of Diverse Active Pharmaceutical Ingredients in Wastewater Remediation during Effluent Treatment Plant (ETP) Processing

Langmuir, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 22, 2025

Pharmaceutical pollution in wastewater poses significant environmental and public health concerns worldwide. Chloramphenicol (CP), an antibiotic widely used medical veterinary applications, is among the active pharmaceutical ingredients (APIs) frequently detected aquatic environments. This study explored encapsulation of chloramphenicol API contaminated using rationally designed fibrations based on silver metal ion-directed self-assembly fibrillator-type self-assembling ligand (ANS-3). We further investigated removal various commonly prescribed drugs, including antibiotics such as β-lactam (amoxicillin), fluoroquinolone (ciprofloxacin), aminoglycoside (neomycin), tetracycline; antiparasitic agents with antiprotozoal properties (praziquantel metronidazole); nonsteroidal anti-inflammatory drugs (NSAIDs) phenylbutazone ketoprofen; vasodilator isoxsuprine; amphiphilic antidepressants (amitriptyline); antiviral drug amantadine. The findings validated crucial influence polar multifunctionality structural complexity enhancing interactions Ag.ANS-3 matrix, emphasizing its potential for efficient sequestration. First, picolinic acid (PA) phenylalanine (F) were evaluated their ability to form fibrillar structures, morphological characterization revealed well-defined networks varying degrees porosity interconnectivity. Then, strategic inclusion leucine synthesizing ANS-3 facilitated formation robust networks, employing hydrophobic drive process. Finally, APIs was Ag(I) ion-driven self-assembled nanofibrous material. research contributes development innovative physicochemical treatment strategies remediation validates importance rational design encapsulation-based technologies.

Language: Английский

---

Amino-Acid-Engineered Bionanozyme Selectivity for Colorimetric Detection of Human Serum Albumin

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Nanozymes are emerging nanomaterials owing to their superior stability and enzyme-mimicking catalytic functions. However, unlike natural enzymes with inherent amino-acid-based recognition motifs for target interactions, manipulating nanozyme selectivity toward specific targets remains a major challenge. In this study, we introduce the de novo strategy using supramolecular assembly of l-tryptophan (l-Trp) as amino acid copper (Cu) ions creating human serum albumin (HSA)-responsive bionanozyme. This amino-acid-engineered bionanozyme enables selective colorimetric detection HSA, critical urinary biomarker kidney diseases, overcoming challenge that HSA is neither typical substrate nor an inhibitor most nanozymes. Kinetic studies competitive tests reveal subdomain IIIA binding l-Trp sites limits electron-transfer-induced structural changes l-Trp-Cu chelate rings, resulting in noncompetitive inhibition. inhibition effect significantly stronger than observed canonical acids, common proteins, interference species. Colorimetric monitoring activity sensitive limit 1.3 nM quantification range 2 10 μM. approach exceptionally more offers broader compared conventional fluorescent methods, suitable diagnostics across various clinical stages disease. innovative rational designing nanozyme–target interactions not only addresses limitations nanozymes but also expands precise applications complex biological systems.

Language: Английский

---

UV-induced plasma welding and interface customization strategy of cellulose nanofiber/silver nanowire composite electrode for advanced flexible photoelectric applications

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: 357, P. 123479 - 123479

Published: March 6, 2025

Language: Английский

---

Self‐assembly of Tyrosine Scaffolds in Aqueous Media: Complex Molecular Architectures from Simple Building Blocks

The Chemical Record, Journal Year: 2025, Volume and Issue: unknown

Published: April 10, 2025

Abstract Mimicking natural systems, self‐assembly has been employed for constructing highly stable and well‐ordered supramolecular structures. Amino acids are frequently used as building blocks in the process due to their advantageous characteristics including easy availability, functionalization, tunable mechanical property, biodegradability. In situ generation of active obtain complex materials via enhanced application biomedical fields bio‐imaging, therapeutics. Single amino acid small building‐block can provide artificial with unique properties. this review, we summarize tyrosine‐derivatives single acid‐based providing assemblies perspectives on potential impact. Finally, discuss ongoing challenges future research.

Language: Английский

---

Solubility of Fmoc-d-tryptophan in twelve mono-solvents: Solvent effects analysis, molecular simulation, model correlation and comparison with structurally similar substances

Journal of Molecular Liquids, Journal Year: 2025, Volume and Issue: 428, P. 127553 - 127553

Published: April 14, 2025

Language: Английский

---

Using Machine Learning to Fast-Track Peptide Nanomaterial Discovery

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: May 29, 2025

Peptides can serve as building blocks for supramolecular materials because of their unique ability to self-assemble, offering potential applications in drug delivery, tissue engineering, and nanotechnology. In this review, we describe peptide self-assembly a sequence- context-dependent process its resulting complexity due the heterogeneity sequences experimental conditions, which makes cross-laboratory reproducibility serious challenge standardized reporting necessity. Given large number possible permutations, machine learning (ML) is suitable navigating search space with aim reducing trial-and-error experimentation speeding up discovery self-assembling peptides. However, point out that ML not point-and-shoot tool be applied directly any problem requires careful consideration, domain knowledge, proper data preparation achieve meaningful results. addition, discuss lack negative reported main limiting factor effective application ML. Considering transformative artificial intelligence, conclude grasping power language models generative approaches, coupled explainability techniques, will expedite nanomaterials discovery.

Language: Английский

---