Engineering Amino Acid and Peptide Supramolecular Architectures through Fluorination

Chemistry - A European Journal, Journal Year: 2024, Volume and Issue: 30(34)

Published: April 18, 2024

Fluorinated non-natural amino acids are attracting considerable research interest, especially in the biomedical field and materials science, thanks to their ability self-assemble into peculiar supramolecular structures. The conformational changes induced by presence of fluorine atoms obviously affect functions, as well biological activity deriving peptides proteins. Here, we will briefly describe main effects fluorination on aggregation behavior such building blocks, focusing particular improved tendency form fibrils, gels therefrom. Our aim is underline promising potential a tool self-assembly features acids, both when used alone inserted polypeptide sequences. influence physical, chemical, structural properties these substrates offers possibility engineer bioinspired with specific tunable functions.

Language: Английский

---

Self-healing glass from a simple peptide — just add water

Nature, Journal Year: 2024, Volume and Issue: 630(8016), P. 308 - 309

Published: June 12, 2024

Language: Английский

---

Fabrication of Hierarchical Nanostructures featuring Amplified Asymmetry through Co‐assembly of Liquid Crystalline Block Copolymer and Chiral Amphiphiles

Angewandte Chemie, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 8, 2024

Abstract The widespread presence of hierarchical asymmetric structures in nature has sparked considerable interest because their unique functionalities. These ingenious across multiple scales often emerge from the transfer and amplification asymmetry chiral molecules under various synergistic effects. However, constructing artificial structures, particularly developing multicomponent analogous to those formed through non‐covalent interactions, still presents tremendous challenges. Herein, we propose a co‐assembly strategy fabricate mesostructures by combining liquid crystalline block copolymer (LC‐BCP) with small molecular amphiphile containing alanine or phenylalanine as linker. Through classic solvent‐exchange process, amphiphiles embedded within LC‐BCP finely regulate LC ordering effect facilitate asymmetry. Consequently, co‐assembled significant chirality features are obtained synergetic Remarkably, subtle alterations side groups amino acids effectively adjust morphology transition. Moreover, covalent bonding sequence emerges critical factor governing formation nanofibers multilayered vesicles exhibiting superhelical sense.

Language: Английский

---

Programmed Self-Assembly of Conjugated Oligomer-Based Helical Nanofibres through Hydrogen Bonding Interactions

Materials Advances, Journal Year: 2024, Volume and Issue: 6(1), P. 241 - 247

Published: Nov. 28, 2024

Self-assembly of m-phenylene vinylene derivatives with amino acid functional groups produces fluorescent nanofibres via hydrogen bonding, chiral centres inducing helicity. These nanostructures exhibit enhanced thermal stability and fluorescence properties, advancing biomimetic material design.

Language: Английский

---

The rise and fall of adenine clusters in the gas phase: a glimpse into crystal growth and nucleation

Analytical and Bioanalytical Chemistry, Journal Year: 2024, Volume and Issue: 416(23), P. 5037 - 5048

Published: July 20, 2024

Language: Английский

---