Artificial Plateletoids Recruit Blood Proteins to Shield Symbiotic Thrombin: a Silk Fibroin/Calcium Interface Medicated Thrombin Generation and Preservation DOI

Zhenghui Shi,

Rongzhen Ma,

Lianqi Shan

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 5, 2024

Abstract Breaking the constraints of thrombin during storage and in vivo applications remains challenging because its low stability sensitivity to environmental temperature acidity. Herein, an artificial plateletoid is developed for situ generation through a co‐incubation approach with plasma vitro, utilizing silk fibroin/Ca 2+ interface, enhance activity generated thrombin. Notably, enzymatic platform as high 30 U g −1 , leading rapid clotting within 55 s, it persisted at least 90 days 37 °C. This considerably lessens difficulties associated maintaining cold chain while storing shipping formulations. Additionally, gastric bleeding model confirmed that improved acid resistance by upregulating pH environment (pH 0.8), facilitating oral delivery effective hemorrhage control highly acidic stomach conditions. pioneering study addresses may provide basis further research on biological approaches.

Language: Английский

Nanoarchitecting intelligently encapsulated designs for improved cancer therapy DOI Creative Commons

Ying‐Tong Ye,

Hong‐Ying Xia,

Jie Li

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: May 1, 2025

Despite the success in exploring various aspects of origination and therapeutic strategies, cancer has remained one most dreadful metabolic disorders due to failure eradicate tumors comprehensively frequent recurrence because acquired resistance drugs. Recently, several advancements have been evidenced fabrication smart nanocarriers encapsulated with multiple components. Several reasons for nanoencapsulation include enhancement bioavailability drugs, precise targetability reduce adverse effects on normal cells, ability enable controlled drug release rates at tumor sites. In addition, these protect cargo from deactivation, responsively delivering it based physiological or pathological characteristics tumors. this review, we present approaches therapy, including organic materials, inorganic components, their composites, as well biomembrane-based strategies. These along practical applications potential treatment, are discussed depth, highlighting advantages disadvantages, aiming reveal ultimate prospects enhancing delivery efficiency targeted therapy.

Language: Английский

Citations

0
Ru induced charge redistribution of MnO2 spheric nanozyme boosted hydrogen sulfide selective detection and cystathionine γ-lyase activity sensitive evaluation DOI
Li Zhao, Xuan Zhang,

Haorong Cheng

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 157904 - 157904

Published: Nov. 1, 2024

Language: Английский

Citations

3
Tumor‐Targeted Catalytic Immunotherapy DOI Open Access

En‐Li Yang,

Wuyin Wang, Yingqi Liu

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 15, 2024

Cancer immunotherapy holds significant promise for improving cancer treatment efficacy; however, the low response rate remains a considerable challenge. To overcome this limitation, advanced catalytic materials offer potential in augmenting by modulating immunosuppressive tumor microenvironment (TME) through precise biochemical reactions. Achieving optimal targeting precision and therapeutic efficacy necessitates thorough understanding of properties underlying mechanisms tumor-targeted materials. This review provides comprehensive systematic overview recent advancements their critical role enhancing immunotherapy. It highlights types reactions, construction strategies materials, fundamental targeting, including passive, bioactive, stimuli-responsive, biomimetic approaches. Furthermore, outlines various tumor-specific strategies, encompassing tissue, cell, exogenous TME-responsive, cellular TME strategies. Finally, discussion addresses challenges future perspectives transitioning into clinical applications, offering insights that pave way next-generation therapies provide substantial benefits to patients settings.

Language: Английский

Citations

1
Ultralow Ru doping MOF-based sensing probe with interface engineering regulation-triggered detection of hydrogen sulfide and cystathionine γ-lyase activity DOI
Hongyuan Shang, Aiping Zhang, Xiaofei Zhang

et al.

Sensors and Actuators B Chemical, Journal Year: 2024, Volume and Issue: 426, P. 136978 - 136978

Published: Dec. 5, 2024

Language: Английский

Citations

0
Artificial Plateletoids Recruit Blood Proteins to Shield Symbiotic Thrombin: a Silk Fibroin/Calcium Interface Medicated Thrombin Generation and Preservation DOI

Zhenghui Shi,

Rongzhen Ma,

Lianqi Shan

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 5, 2024

Abstract Breaking the constraints of thrombin during storage and in vivo applications remains challenging because its low stability sensitivity to environmental temperature acidity. Herein, an artificial plateletoid is developed for situ generation through a co‐incubation approach with plasma vitro, utilizing silk fibroin/Ca 2+ interface, enhance activity generated thrombin. Notably, enzymatic platform as high 30 U g −1 , leading rapid clotting within 55 s, it persisted at least 90 days 37 °C. This considerably lessens difficulties associated maintaining cold chain while storing shipping formulations. Additionally, gastric bleeding model confirmed that improved acid resistance by upregulating pH environment (pH 0.8), facilitating oral delivery effective hemorrhage control highly acidic stomach conditions. pioneering study addresses may provide basis further research on biological approaches.

Language: Английский

Citations

0