Cited by Gadolinium-Ceria Hybrid System Enables Synergistic Alleviation of Oxidative Stress and Metabolic Thrombo-Inflammation for Efficient Ischemic Stroke Treatment

Shikonin-loaded PLGA nanoparticles: A promising strategy for psoriasis treatment DOI

Jing Fu, Longtai You,

Daohan Sun

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(11), P. e31909 - e31909

Published: May 24, 2024

Psoriasis is an inflammation-based skin illness marked by aggravated proliferation of epidermal cells. Shikonin a natural naphthoquinone obtained from Arnebiae radix. It exerts anti-inflammatory and immunosuppressive effects. However, the poor water solubility low bioavailability shikonin limit its application. In this study, shikosin-loaded PLGA nanoparticle hydrogel was prepared used to deliver drug epidermis psoriasis mice through local administration. The results demonstrated that nanoparticles inhibited HaCaT cell multiplication, increased uptake, induced apoptosis Results Western blotting assays indicated shikosin down-regulated protein expressions p65 p-p65. Furthermore, mitigated decreased concentrations inflammation-inducing cytokines, i.e., IL17A, IL-17F, IL-22, IL-1β, TNF-α. Taken together, these suggest shikonin-PLGA loaded in system possess promising therapeutic potential for psoriasis.

Language: Английский

Citations

Advancing CNS Therapeutics: Enhancing Neurological Disorders with Nanoparticle-Based Gene and Enzyme Replacement Therapies DOI

Shuhan Liu, Haisong Li,

Shiwen Xi

et al.

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 1443 - 1490

Published: Feb. 1, 2025

Abstract: Given the complexity of central nervous system (CNS) and diversity neurological conditions, increasing prevalence disorders poses a significant challenge to modern medicine. These disorders, ranging from neurodegenerative diseases psychiatric not only impact individuals but also place substantial burden on healthcare systems society. A major obstacle in treating these conditions is blood-brain barrier (BBB), which restricts passage therapeutic agents brain. Nanotechnology, particularly use nanoparticles (NPs), offers promising solution this challenge. NPs possess unique properties such as small size, large surface area, modifiable characteristics, enabling them cross BBB deliver drugs directly affected brain regions. This review focuses application gene therapy enzyme replacement (ERT) for disorders. Gene involves altering or manipulating expression can be enhanced by designed carry various genetic materials. Similarly, improve efficacy ERT lysosomal storage (LSDs) facilitating delivery brain, overcoming issues like immunogenicity instability. Taken together, explores potential revolutionizing treatment options highlighting their advantages future directions rapidly evolving field. Keywords: system, nanoparticle, therapy,

Language: Английский

Citations

Sustained Release of Dual p38 Inhibitors via Supramolecular Hydrogels to Enhance Cardiac Repair after MI/R Injury DOI

Di Wang,

Aoxue Xu,

Haitao Su

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 7, 2025

Abstract Activation of p38 mitogen-activated protein kinase plays an important role in the progression ventricular muscle inflammation after myocardial ischemia-reperfusion (MI/R). The inhibition activation ischemic myocardium can reduce remodeling post-MI. However, owing to dynamic change MI, clinical therapeutic effect inhibitors is insufficient. Herein, we describe design a hydrogelator Nap-Phe-Phe-Thr-Gly-Tyr-OH (Nap-TGY) coassemble inhibitor SB202190 (SB), responsive supramolecular hydrogel (Gel Nap-TGY+SB) for local administration and release SB efficiently improve inflammatory microenvironment. Under overexpression myocardium, Nap-TGY phosphorylated yield hydrophilic Nap-Phe-Phe-Thr(H2PO3)-Gly-Tyr(H2PO3) (Nap-TpGYp), triggering disassembly inhibitor. Injection into significantly reduces phosphorylation, mitigates inflammation, enhances angiogenesis. These findings suggest novel strategy cardiomyopathy through modulation (MAPK) pathway.

Language: Английский

Citations

Sustained Release of Dual P38 Inhibitors Via Supramolecular Hydrogels to Enhance Cardiac Repair after Mi/R Injury DOI

Yaguang Wang, Di Wang,

Aoxue Xu

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

Gadolinium-Ceria Hybrid System Enables Synergistic Alleviation of Oxidative Stress and Metabolic Thrombo-Inflammation for Efficient Ischemic Stroke Treatment DOI

Nan Jin,

Chundongqiu Xia,

Jingyi Zhang

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: unknown, P. 123379 - 123379

Published: April 1, 2025

Language: Английский

Citations