Ferroptosis mediated inhibition of breast cancer cells by β–elemene incorporated GSH/pH dual responsive nanomicelles DOI
Shan Shen, Ran Xie, Yiqun Wang

et al.

European Polymer Journal, Journal Year: 2024, Volume and Issue: unknown, P. 113677 - 113677

Published: Dec. 1, 2024

Language: Английский

Ferroptosis: A double-edged sword DOI Creative Commons

Shengmei Wang,

Qiuyan Guo, Lili Zhou

et al.

Cell Death Discovery, Journal Year: 2024, Volume and Issue: 10(1)

Published: May 30, 2024

Abstract Ferroptosis represents a form of programmed cell death that is propelled by iron-dependent lipid peroxidation, thereby being distinguished the prominent features iron accumulation and peroxidation. has been implicated in numerous physiological pathological phenomena, with mounting indications it holds significant implications for cancer other medical conditions. On one side, demonstrates anti-cancer properties triggering ferroptosis within malignant cells, on hand, damages normal cells causing diseases. Therefore, this paper, we propose to review paradoxical regulation tumors First, introduce development history, concept mechanism ferroptosis. The second part focuses methods inducing tumors. third section emphasizes utilization different conditions strategies inhibit fourth elucidates key contradictions control Finally, potential research avenues associated domains are suggested.

Language: Английский

Citations

18
A Dual‐Targeting Biomimetic Nanoplatform Integrates SDT/CDT/Gas Therapy to Boost Synergistic Ferroptosis for Orthotopic Hepatocellular Carcinoma Therapy DOI Creative Commons
Wen Meng, Ting Chen, Xueping Li

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

Abstract The development of efficient therapeutic strategies to promote ferroptotic cell death offers significant potential for hepatocellular carcinoma (HCC) treatment. Herein, this study presents an HCC‐targeted nanoplatform that integrates bimetallic FeMoO 4 nanoparticles with CO‐releasing molecules, and further camouflaged SP94 peptide‐modified macrophage membrane enhanced ferroptosis‐driven multi‐modal therapy HCC. Leveraging the multi‐enzyme activities multivalent metallic elements, not only decomposes H 2 O generate oxygen alleviate tumor hypoxia but also depletes glutathione inactivate peroxides 4, which amplify sonodynamic under ultrasound (US) irradiation. Meanwhile, catalyzes Fenton reaction produce hydroxyl radicals chemodynamic therapy. Elevated intracellular reactive species trigger cascade release CO, leading lethal lipid peroxidation enhancing ferroptosis‐mediated This demonstrates robust anti‐tumor efficacy US irradiation favorable biosafety in both subcutaneous orthotopic HCC models, representing a promising approach Additionally, findings offer new insights into microenvironment modulation optimize US‐triggered cancer

Language: Английский

Citations

2
Pitavastatin and resveratrol bio-nanocomplexes against hyperhomocysteinemia-induced atherosclerosis via blocking ferroptosis-related lipid deposition DOI

Anning Yang,

Hongwen Zhang, Huiping Zhang

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113598 - 113598

Published: March 1, 2025

Language: Английский

Citations

2
Regulation of ROS balance in the tumor microenvironment achieves reversal of immune suppression and deep penetration of nanomedicines DOI

Zichuang Xu,

Rongrong Fan, Xuhao Zhang

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 159716 - 159716

Published: Jan. 1, 2025

Language: Английский

Citations

0
Bufotalin loaded Biomimetic nanodrug for combined chemo/photodynamic therapy of cancer DOI Creative Commons
Simin Chen,

Jialong Fan,

Qian Xie

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101684 - 101684

Published: March 1, 2025

Language: Английский

Citations

0
Smart self-assembled nanomedicine for ferroptotic tumor therapy DOI
Liang Chen, Tian Zhang, Qingming Zhang

et al.

Colloids and Interface Science Communications, Journal Year: 2025, Volume and Issue: 66, P. 100829 - 100829

Published: March 21, 2025

Language: Английский

Citations

0
PFOS Exposure Impairs Porcine Oocyte Maturation and Embryo Development via Mitochondria-Dependent Ferroptosis DOI
Xiaoqing Sun, Ran Teng, Ning Xu

et al.

Environmental Pollution, Journal Year: 2025, Volume and Issue: unknown, P. 126185 - 126185

Published: April 1, 2025

Language: Английский

Citations

0
Study on a TCM evaluation method based on an MIP-modified MOF sensor with highly selective electrocatalytic activity—an Artemisia annua L. perspective DOI
Jingbo Zhang, Quancheng Chen,

Xuemin Gao

et al.

Analytical Methods, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Quantitative analysis of artemisinin (ART) in Artemisia annua decoction samples is crucial for the quality assessment samples; however, no comprehensive solution currently exists its rapid and sensitive quantification.

Language: Английский

Citations

0
Acid-activated mitochondria-targeting nanoprodrug for reactive oxygen species (ROS)-tolerant cancer therapy via antioxidant defense inhibition DOI
Zihao Teng, Chen Liu,

Xiangfu Du

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113843 - 113843

Published: May 1, 2025

Language: Английский

Citations

0
Mitochondria-specific GPX4 inhibition enhances ferroptosis and antitumor immunity DOI
Jian Xiao, Nana Feng, Qiushi Li

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113841 - 113841

Published: May 1, 2025

Language: Английский

Citations

0