Nanocomposite Hydrogels: A Promising Approach for the Treatment of Degenerative Joint Diseases DOI Creative Commons
Qizhu Chen, Zitian Zheng,

Mian Lin

et al.

Small Science, Journal Year: 2024, Volume and Issue: 4(11)

Published: Sept. 3, 2024

Degenerative joint diseases, as a global public health issue, impose significant burdens on patients' lives and substantial economic costs society. Currently, the primary modalities include physical therapy, pharmaceutical intervention, surgical procedures. None of these approaches can alter course this degenerative process. Due to their commendable biocompatibility, biodegradability, heightened efficacy in drug delivery, hydrogels present themselves novel noninvasive remedy for ailments. However, clinical application still faces some challenges, including uncontrolled discharge encapsulated medications, absence adequate mechanical reinforcement destabilized joints, adaptability fluctuating microenvironments. Recently, nanocomposite hydrogels, formed by introducing nanomaterials into or chemical means, improve limitations extend potential biological applications diseases. In study, pathologic features diseases multiple different types targeting are briefly described. It also concludes with an outlook use settings discusses challenges limitations.

Language: Английский

Advances in Hydrogels for Meniscus Tissue Engineering: A Focus on Biomaterials, Crosslinking, Therapeutic Additives DOI Creative Commons

Zhuxing Zhou,

Jiajie Wang, Chaoqian Jiang

et al.

Gels, Journal Year: 2024, Volume and Issue: 10(2), P. 114 - 114

Published: Feb. 1, 2024

Meniscus tissue engineering (MTE) has emerged as a promising strategy for meniscus repair and regeneration. As versatile platforms, hydrogels have gained significant attention in this field, they possess tunable properties that allow them to mimic native extracellular matrices provide suitable microenvironment. Additionally, can be minimally invasively injected adjusted match the shape of implant site. They conveniently effectively deliver bioactive additives demonstrate good compatibility with other functional materials. These inherent qualities made hydrogel candidate therapeutic approaches This article provides comprehensive review advancements research on application engineering. Firstly, biomaterials crosslinking strategies used formation are summarized analyzed. Subsequently, role additives, including cells, growth factors, active products, facilitating regeneration is thoroughly discussed. Furthermore, we summarize key issues designing MTE. Finally, conclude current challenges encountered by applications suggest potential solutions addressing these field We hope resource researchers practitioners interested thereby exploration new design possibilities.

Language: Английский

Citations

5
Strong and tough chitin hydrogel constructed by dehydration and rehydration strategy DOI
Ruirui Liu, Li‐Bo Mao, Shu‐Hong Yu

et al.

Nano Research, Journal Year: 2024, Volume and Issue: 17(9), P. 8192 - 8199

Published: June 24, 2024

Language: Английский

Citations

4
Sea-Island Micelle Structured Hydrogel Scaffold: A Dual-Action Approach to Combat Cartilage Damage under RA Conditions DOI

Abudureheman Bahatibieke,

Jianming Zhao, Danping Fan

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: 17(2), P. 2911 - 2923

Published: Jan. 2, 2025

Rheumatoid arthritis (RA) is a common autoimmune joint disease characterized by persistent synovial inflammation and cartilage damage. The current clinical treatments primarily utilize drugs such as triptolide (TP) to address inflammation, yet they are unable directly repair damaged cartilage. Furthermore, the often undermines effectiveness of traditional strategies, preventing them from achieving optimal outcomes. To tackle this challenge, study successfully developed drug-loaded polyurethane hydrogel-oriented porous scaffold, designed facilitate under RA conditions. A hydrogel was formed via solvent-induced polyurethane-gelatin, resulting in scaffold TP@GSPU. sea-island micelle structure TP@GSPU enables efficient loading TP. release TP vivo environment regulates expression inflammatory factors macrophages, thereby improving microenvironment within cavity. Additionally, gelatin component provides robust support for regeneration. efficacy regulating facilitating conditions, which demonstrated through damage experiments conducted rat collagen-induced (CIA) model. design scheme material offers potential approach conditions RA.

Language: Английский

Citations

0
Recent applications of stimulus-responsive smart hydrogels for osteoarthritis therapy DOI Creative Commons
Zhuoming Xu, Jintao Liu,

Hanyin Hu

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 17, 2025

Osteoarthritis is one of the most common degenerative joint diseases, which seriously affects life middle-aged and elderly people. Traditional treatments such as surgical treatment systemic medication, often do not achieve expected or optimal results, leads to severe trauma a variety side effects. Therefore, there an urgent need develop novel therapeutic options overcome these problems. Hydrogels are widely used in biomedical tissue repairing platform for loading drugs, proteins stem cells. In recent years, smart-responsive hydrogels have achieved excellent results drug delivery systems osteoarthritis. This review focuses on advances endogenous stimuli (including enzymes, pH, reactive oxygen species temperature, etc.) responsive exogenous light, shear, ultrasound magnetism, osteoarthritis treatment. Finally, current limitations application future prospects smart summarized.

Language: Английский

Citations

0
Bioinspired design of strong, tough and slippery hydrogels beyond the natural soft tissues DOI
Kai Chen, Qin Chen, Xiaodong Yan

et al.

Materials Today Chemistry, Journal Year: 2025, Volume and Issue: 45, P. 102633 - 102633

Published: March 9, 2025

Language: Английский

Citations

0
Cartilage Lubrication from the Perspective of Wettability DOI

Xuhao Yang,

Feng Gao, Wenlong Song

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

Cartilage exhibits an extremely low friction and very wearability within the liquid environment of joint. It is also capable switching wettability between superhydrophilicity hydrophobicity in both wetting dry conditions (specific experimental operations or open wounds). Therefore, understanding cartilage lubrication from perspective provides inspiration for design artificial sections with motion soft actuators coefficients (COF). In this review, articular introduced discussed view wettability. First, basic principles are described a focus on compositions cartilage, particular relationship phospholipid layers supramolecular synergy synovial fluid cartilage. Subsequently, under different stimuli (such as shear, pH, temperature, electric field) insights into lubrication. Finally, we present comprehensive summary delineate challenges domain assisting researchers formulating viable concepts efficient substitution smart lubricating devices.

Language: Английский

Citations

0
Self‐Lubricating and Self‐Healing Polyurethane Elastomer as a Meniscal Prosthesis to Delay Osteoarthritis Progression DOI
Yi Zhou, Xia Jiang, Xiaolong Yang

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 14, 2025

Abstract The absence of a meniscal prosthesis that fully accommodates the complex motion demands human knee joint remains challenge in clinical practice. This study synthesized polyurethane elastomer with enhanced mechanical properties, featuring dynamic dimethyldioxime‐urethane structure provides self‐healing capabilities. Additionally, adamantane‐grafted hyaluronic acid has been integrated into containing cyclodextrin, imparting self‐lubricating properties through supramolecular host‐guest interactions between adamantane and cyclodextrin. innovative is utilized to fabricate (DPU@HA). In vitro experiments demonstrated DPU@HA's exceptional cytocompatibility chondrocytes. vivo studies revealed DPU@HA significantly protected articular cartilage following meniscus removal by reducing high stress within cartilage, thereby inhibiting Piezo1 overactivation subsequent chondrocyte apoptosis. With its (DPU@HA) holds promise for applications preventing progression osteoarthritis after meniscectomy.

Language: Английский

Citations

0
Nicotinamide Adenine Dinucleotide-Loaded Lubricated Hydrogel Microspheres with a Three-Pronged Approach Alleviate Age-Related Osteoarthritis DOI Creative Commons

Yanpeng Lin,

Hangtian Wu,

Jun Wang

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: May 2, 2025

Chondrocyte senescence, synovitis, and decreased level of lubrication play pivotal roles in the pathogenesis age-related osteoarthritis (AROA). However, there are currently no effective therapeutic interventions capable altering progression OA until it reaches advanced stages, necessitating joint replacement. In this study, lubricious drug-loaded hydrogel microspheres were designed fabricated by utilizing microfluidic technology for radical polymerization chondroitin sulfate methacrylate incorporating nicotinamide adenine dinucleotide (NAD)-loaded liposomes modified with lactoferrin that positively charged. Mechanical, tribological, drug release analyses demonstrated enhanced properties an extended dissemination time NAD@NPs@HM microspheres. vitro assays unveiled ability to counteract chondrocyte senescence. RNA sequencing analysis, untargeted metabolomics experiments on macrophages revealed can regulate metabolic reprogramming synovial macrophages, promoting their repolarization from M1 M2 phenotype, thereby alleviating synovitis. Intra-articular injection aged mice reduced mechanisms associated AROA. These results suggest may provide release, improved leading better gait, attenuation AROA pathogenic processes, indicating its potential as a approach

Language: Английский

Citations

0
Core-shell structured nanomembrane with sequential immune and vascular isolation effects followed by chondrogenic induction to promote stable stem cell-based subcutaneous cartilage regeneration in large animals DOI
Erji Gao, Ziming Wang, Shaohua Zhao

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 498, P. 154878 - 154878

Published: Aug. 15, 2024

Language: Английский

Citations

3
Controlled Stimulus-Responsive Delivery Systems for Osteoarthritis Treatment DOI Open Access
Qianwen Ye,

Mingshuo Zhang,

Shuyue Li

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(21), P. 11799 - 11799

Published: Nov. 2, 2024

Osteoarthritis (OA), a common and disabling degenerative joint disease, affects millions of people worldwide imposes considerable burden on patients society due to its high prevalence economic costs. The pathogenesis OA is closely related the progressive degradation articular cartilage accompany inflammation; however, itself cannot heal modulate inflammation lack nerves, blood vessels, lymph-vessels. Therefore, reliable effective methods treat remain highly desired. Local administration drugs or bioactive materials by intra-articular injection delivery system represents promising approach OA, especially considering prolonged retention, chondrocytes targeting, stimuli-responsive release achieve precision therapy. This article summarizes discusses advances in currently used systems (nanoparticle, hydrogel, liposome, microsphere) then focuses their applications treatment from perspective endogenous stimulus (redox reactions, pH, enzymes, temperature) exogenous (near-infrared, magnetic, ultrasound)-responsive release. Finally, challenges potential future directions for development nano-delivery are summarized.

Language: Английский

Citations

3