Extracellular Vesicle‐Inspired Minimalist Flexible Nanocapsules Assembled with Whole Active Ingredients for Highly Efficient Enhancement of DC‐Mediated Tumor Immunotherapy DOI Creative Commons
Ao He, Qiang Li, Meng Dang

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: July 25, 2024

The development of nanovaccines capable eliciting tumor-specific immune responses holds significant promise for tumor immunotherapy. However, many nanovaccine designs rely heavily on incorporating multiple adjuvants and carriers, increasing the biological hazards associated with these additional components. Here, this work introduces novel flexible nanocapsules (OVAnano) designed to mimic extracellular vesicles, primarily using ovalbumin antigen minimal polyethylenimine adjuvant These results show that biomimetic structure OVAnano facilitates enhanced uptake by dendritic cells (DCs), leading efficient release into cytosol via endosomal escape, ultimately, successful cross-presentation DCs. Furthermore, modulates intracellular nuclear factor kappa-B (NF-κB) signaling pathway, promoting DC maturation. highly purified antigens in demonstrate remarkable antigen-specific immunogenicity, triggering strong antitumor mediated Therapeutic vaccination studies have also shown administration effectively suppresses growth mice inducing from CD8

Language: Английский

Latest advancements and trends in biomedical polymers for disease prevention, diagnosis, treatment, and clinical application DOI

Mingxia Jiang,

Huapan Fang,

Huayu Tian

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 380, P. 138 - 174

Published: Feb. 5, 2025

Language: Английский

Citations

2
A Minimalist Pathogen‐Like Sugar Nanovaccine for Enhanced Cancer Immunotherapy DOI Open Access

Miao Yu,

Le Niu,

Xinying Lv

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 29, 2024

Pathogen-mimicking nanoparticles have emerged at the forefront of vaccine delivery technology, offering potent immune activation and excellent biocompatibility. Among these innovative carriers, mannan, a critical component yeast cell walls, shows promise as an exemplary carrier. Nevertheless, it faces challenges like unpredictable immunogenicity, rapid elimination, limited antigen loading due to high water solubility. Herein, mannan with varying carbon chain ratios is innovatively modified, yielding series dodecyl chains modified (Mann-C

Language: Английский

Citations

7
Supramolecular charge-reversal pillar[6]arenes-oxaliplatin system for cancer therapy with reduced toxicity and enhanced efficacy DOI
Ping Yang, Kairong Zhao, Shuai Zhao

et al.

Journal of Industrial and Engineering Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Extracellular Vesicle‐Inspired Minimalist Flexible Nanocapsules Assembled with Whole Active Ingredients for Highly Efficient Enhancement of DC‐Mediated Tumor Immunotherapy DOI Creative Commons
Ao He, Qiang Li, Meng Dang

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: July 25, 2024

The development of nanovaccines capable eliciting tumor-specific immune responses holds significant promise for tumor immunotherapy. However, many nanovaccine designs rely heavily on incorporating multiple adjuvants and carriers, increasing the biological hazards associated with these additional components. Here, this work introduces novel flexible nanocapsules (OVAnano) designed to mimic extracellular vesicles, primarily using ovalbumin antigen minimal polyethylenimine adjuvant These results show that biomimetic structure OVAnano facilitates enhanced uptake by dendritic cells (DCs), leading efficient release into cytosol via endosomal escape, ultimately, successful cross-presentation DCs. Furthermore, modulates intracellular nuclear factor kappa-B (NF-κB) signaling pathway, promoting DC maturation. highly purified antigens in demonstrate remarkable antigen-specific immunogenicity, triggering strong antitumor mediated Therapeutic vaccination studies have also shown administration effectively suppresses growth mice inducing from CD8

Language: Английский

Citations

2