Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)
Published: May 3, 2025
Language: Английский
Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(12), P. 5161 - 5180
Published: Aug. 23, 2024
Microneedles (MNs) serve as a revolutionary paradigm in transdermal drug delivery, heralding viable resolution to the formidable barriers presented by cutaneous interface. This review examines MNs an advanced approach enhancing dermatological pathology management. It explores complex dermis structure and highlights limitations of traditional methods, emphasizing MNs' advantage bypassing stratum corneum deliver drugs directly subdermal matrix. The discourse outlines diverse typologies MNs, including solid, coated, hollow, hydrogel, dissolvable versions. Each type is characterized its unique applications benefits. treatise details deployment alleviation cancers, administration inflammatory dermatoses such psoriasis atopic dermatitis, their utility wound Additionally, paper contemplates prospects within realm aesthetic dermatology burgeoning market traction cosmetic MN formulations. summarizes scientific commercial challenges clinical adoption therapeutics, dosage calibration, pharmacodynamics, biocompatibility, patient compliance, sterilization, mass production, regulatory oversight. emphasizes need for ongoing research, innovation, harmonization overcome these obstacles fully realize potential treating skin diseases improving welfare. presents comprehensive overview recent accomplishments, remaining challenges, future microneedle-facilitated therapy afflictions.
Language: Английский
Citations
25
Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 529, P. 216470 - 216470
Published: Jan. 28, 2025
Language: Английский
Citations
13
Topics in Current Chemistry, Journal Year: 2025, Volume and Issue: 383(1)
Published: Feb. 18, 2025
Language: Английский
Citations
6
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 19, 2024
Abstract Hydrogel‐forming microneedles are constructed from or coated with polymeric, hydrophilic materials that swell upon insertion into the skin. Designed to dissolve disintegrate postinsertion, these can deliver drugs, vaccines, other therapeutics. Recent advancements have broadened their application scope include collection, transport, and extraction of dermal interstitial fluid (ISF) for medical diagnostics. This review presents a brief introduction characteristics ISF, methods sampling, critical assessment state‐of‐the‐art in hydrogel‐forming ISF Key factors evaluated including material composition, swelling behavior, biocompatibility, mechanical strength necessary effective microneedle performance collection. The also discusses successful examples assays sensor integrations, highlighting notable achievements, identifying research opportunities, addressing challenges potential solutions. Despite predominance synthetic hydrogels reported technologies due favorable gelation properties, there is significant variety biopolymers composites literature. field lacks consensus on optimal material, fabrication methods, though emerging evidence suggests processing techniques utility
Language: Английский
Citations
12
TrAC Trends in Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 118156 - 118156
Published: Jan. 1, 2025
Language: Английский
Citations
2
ACS Nano, Journal Year: 2024, Volume and Issue: 18(35), P. 23876 - 23893
Published: Aug. 23, 2024
Fully integrated theranostic devices are highly esteemed in clinical applications, offering immense potential real-time disease monitoring and personalized care. Microneedles (MNs), as innovative wearable devices, boast important advantages biosensing therapy, thus holding significant promise the advancement of diagnostic therapeutic platforms. Encouragingly, advancements electrochemical sensing technology, micronano fabrication, biocompatible materials propelling momentum for MNs-based closed-loop systems, enhancing detection capabilities, biocompatibility, cost-effectiveness. Moreover, notable progress integrating MN chips with other biochips signifies a frontier growth. Successful trials target molecule drug delivery domains herald excellent translational prospects aforementioned platform. Finally, we delineate both challenges opportunities development including continuous monitoring, intelligent control algorithms, safety, regulatory considerations.
Language: Английский
Citations
9
International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: unknown, P. 124995 - 124995
Published: Nov. 1, 2024
Language: Английский
Citations
7
Advanced Materials Interfaces, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 9, 2025
Abstract Continuous monitoring of protein biomarkers in interstitial fluid (ISF) is essential for improving patient care and outcomes. This study presents a novel electrochemical impedance spectroscopy (EIS) sensor utilizing microneedles (MNs) patterned with interdigitated electrodes the detection vascular endothelial growth factor (VEGF). The MNs, are fabricated from flexible polylactide (PLA) using simple molding technique, followed by metal deposition an pattern to serve as platform EIS sensor. After functionalization anti‐VEGF antibodies, measurements conducted detect VEGF levels, demonstrating significant change response varying concentrations target biomarker. MNs can easily penetrate rat skin hand, puncturing without mechanical breakage. innovative approach enhances sensitivity specificity biomarker paves way continuous applications diagnostics preventative medicine.
Language: Английский
Citations
1
ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: 17(9), P. 13279 - 13301
Published: Feb. 19, 2025
The advancements in wearable sensor technology have revolutionized noninvasive body fluid monitoring, offering new possibilities for continuous and real-time health assessment. By analyzing fluids such as sweat, saliva, tears, interstitial fluid, these technologies provide painless diagnostic alternatives detecting biomarkers glucose, electrolytes, metabolites. These sensors play a crucial role early disease detection, chronic condition management, personalized healthcare. Recent innovations flexible electronics, microfluidic systems, biosensing materials significantly improved the accuracy, reliability, integration of into everyday textiles. Moreover, convergence artificial intelligence big data analytics has enhanced precision personalization monitoring transforming powerful tools holographic inspection. Despite significant progress, challenges remain, including improving stability dynamic environments, achieving transmission, covering broader range biomarkers. Future research directions focus on enhancing material sustainability through green synthesis, optimizing sampling techniques, leveraging machine learning to further improve performance. This Review highlights transformative potential medical applications, aiming bridge gaps healthcare accessibility elevate standards patient care technologies.
Language: Английский
Citations
1
Journal of Alloys and Compounds, Journal Year: 2025, Volume and Issue: unknown, P. 179341 - 179341
Published: Feb. 1, 2025
Language: Английский
Citations
1