Natural mineral drugs inspired functional nanomaterials: design, synthesis, and biomedical applications DOI

Yefan Duan,

Xiangdong Ding,

Elizat Ablikim

et al.

Journal of the American Ceramic Society, Journal Year: 2025, Volume and Issue: unknown

Published: May 5, 2025

Abstract Functional nanomaterials inspired by natural minerals hold significant promise for biomedical applications, attributed to their distinctive physicochemical characteristics. This study explores the impact of contemporary technology on advancement nanoscale transformation mineral drugs, taking into account historical applications. Through “top‐down” and “bottom‐up” synthesis strategies, size morphology are controlled precisely optimize bioavailability efficacy. In realm these have proven be highly effective in both standalone combined therapies, notably enhancing targeted drug delivery, magnetic resonance imaging, photothermal therapy. Furthermore, article delves cutting‐edge delivery methods that leverage extracellular space. These anticipated overcome constraints imposed blood‐brain barrier open new avenues treating brain diseases. The extensive utilization renowned exceptional biosafety therapeutic effectiveness, establishes a robust foundation integrating nanotechnology. integration holds great advancing clinical translation drugs. Future research must delve deeper evaluating stability potential use materials within broad spectrum

Language: Английский

Oxidative Stress and Reprogramming of Lipid Metabolism in Cancers DOI Creative Commons
Siqi Li, Hang Yuan, Liang Li

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(2), P. 201 - 201

Published: Feb. 10, 2025

Oxidative stress is a common event involved in cancer pathophysiology, frequently accompanied by unique lipid metabolic reprogramming phenomena. caused mainly an imbalance between the production of reactive oxygen species (ROS) and antioxidant system cells. Emerging evidence has reported that oxidative regulates expression activity metabolism-related enzymes, leading to alteration cellular metabolism; this involves significant increase fatty acid synthesis shift way which lipids are taken up utilized. The dysregulation metabolism provides abundant intermediates synthesize biological macromolecules for rapid proliferation cells; moreover, it contributes maintenance intracellular redox homeostasis producing variety reducing agents. Moreover, derivatives metabolites play critical roles signal transduction within cells tumor microenvironment evades immune destruction facilitates invasion metastasis. These findings suggest close relationship during malignant progression cancers. This review focuses on crosstalk reprogramming, in-depth insight into modulation ROS cancers discusses potential strategies targeting therapy.

Language: Английский

Citations

3
Potentiated Calcium Carbonate with Enhanced Calcium Overload Induction and Acid Neutralization Capabilities to Boost Chemoimmunotherapy against Liver Cancer DOI

Liyun Zheng,

Yiming Ding,

Shiji Fang

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(40), P. 27597 - 27616

Published: Sept. 29, 2024

Unfavorable phenotypes characterized by low immunogenicity and acidity within the tumor microenvironment (TME) contribute to immunosuppression therapeutic resistance. Herein, we rationally synthesized a multifunctional nanoregulator encapsulating DOX erianin into calcium carbonate (CaCO

Language: Английский

Citations

9
The Role of Cholesterol Metabolism and Its Regulation in Tumor Development DOI Creative Commons

Yongmei Wu,

Wenqian Song,

Su Min

et al.

Cancer Medicine, Journal Year: 2025, Volume and Issue: 14(7)

Published: March 27, 2025

ABSTRACT Background Within the tumor microenvironment, cells undergo metabolic reprogramming of cholesterol due to intrinsic cellular alterations and changes in extracellular milieu. Furthermore, within this microenvironment influences immune landscape tumors, facilitating evasion consequently promoting tumorigenesis. These biological involve modifications numerous enzymes associated with uptake synthesis, including NPC1L1, SREBP, HMGCR, SQLE, PCSK9. Review This review systematically summarizes role metabolism its cancer progression, examines mechanisms through which dysregulation affects discusses recent advancements therapies that target metabolism. Conclusion Targeting metabolism‐related can inhibit growth, reshape landscapes, rejuvenate antitumor immunity, offering potential therapeutic avenues treatment.

Language: Английский

Citations

1
Nanomaterials in the diagnosis and treatment of gastrointestinal tumors: New clinical choices and treatment strategies DOI Creative Commons
Liping Chen,

Qingqing Li

Materials Today Bio, Journal Year: 2025, Volume and Issue: 32, P. 101782 - 101782

Published: April 19, 2025

Language: Английский

Citations

1
Novel Peptide-Modified Zeolitic Imidazolate Framework-8 Nanoparticles with pH-Sensitive Release of Doxorubicin for Targeted Treatment of Colorectal Cancer DOI Creative Commons
Liming Gong, Heming Zhao, Liqing Chen

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(2), P. 246 - 246

Published: Feb. 13, 2025

Background: Colorectal cancer (CRC) is one of the common malignant tumors. Chemotherapeutic agents represented by doxorubicin (DOX) are adjuvant therapies for patients with advanced CRC. However, DOX suffers from dose-dependent cardiotoxicity and myelosuppression due to a lack targeting specificity, which severely limits its clinical application. Methods: Herein, we constructed zeolitic imidazolate framework-8 (ZIF-8) modified novel peptide (LT peptide) deliver chemotherapeutic drug targeted treatment Results: In this study, LT-PEG@DOX@ZIF-8 nanoparticles were prepared simple method suitable particle size zeta potential, also capable pH-responsive release. vitro assays exhibited that effectively taken up C26 cells, significantly inhibited cell proliferation, induced apoptosis. Furthermore, in mice models colorectal tumors, displayed specific tumor aggregation exerted anti-tumor effects prolong survival mice. Conclusions: conclusion, provides promising strategy delivery treat

Language: Английский

Citations

0
Superhydrophilic Bi-methylimidazole for Preferred pH-Responsive, Targeted Drug Delivery to Tumor DOI
Ruizhuo Ouyang,

W.Y. Xue,

Penghui Cao

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 253, P. 114701 - 114701

Published: April 14, 2025

Language: Английский

Citations

0
Natural mineral drugs inspired functional nanomaterials: design, synthesis, and biomedical applications DOI

Yefan Duan,

Xiangdong Ding,

Elizat Ablikim

et al.

Journal of the American Ceramic Society, Journal Year: 2025, Volume and Issue: unknown

Published: May 5, 2025

Abstract Functional nanomaterials inspired by natural minerals hold significant promise for biomedical applications, attributed to their distinctive physicochemical characteristics. This study explores the impact of contemporary technology on advancement nanoscale transformation mineral drugs, taking into account historical applications. Through “top‐down” and “bottom‐up” synthesis strategies, size morphology are controlled precisely optimize bioavailability efficacy. In realm these have proven be highly effective in both standalone combined therapies, notably enhancing targeted drug delivery, magnetic resonance imaging, photothermal therapy. Furthermore, article delves cutting‐edge delivery methods that leverage extracellular space. These anticipated overcome constraints imposed blood‐brain barrier open new avenues treating brain diseases. The extensive utilization renowned exceptional biosafety therapeutic effectiveness, establishes a robust foundation integrating nanotechnology. integration holds great advancing clinical translation drugs. Future research must delve deeper evaluating stability potential use materials within broad spectrum

Language: Английский

Citations

0