Controlled Synthesis of the FeB Nanometallic Glasses with Stronger Electron Donating Capability to Activate Molecular Oxygen for the Enhanced Ferroptosis Therapy DOI

Guanjie Shi,

Yongxuan Zhang,

Wenting Wang

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 8, 2024

Abstract Considering the strong electron‐donating ability and superior biocompatibility, integration of zero‐valent iron nanostructure Fe 0 (electron‐reservoir) boron B offers great promise for fabricating novel ferroptosis nanoagents. Nevertheless, controlled facile synthesis alloyed nanostructure‐FeB nanometallic glasses (NMGs) has remained a long‐standing challenge. Herein, complexion‐reduction strategy is proposed FeB NMGs with greater electron donating capacity to activate molecular oxygen improved therapy. In‐depth mechanism reveales that effectively prevent long‐range diffusion , resulting in amorphous nanoparticles (FeB NPs). The NPs display stronger capability transfer rate 9.4 times higher than NPs, which produce ∙O 2 − H O ∙OH. vitro cellular experiments confirm FeB‐ss‐SiO₂ (encapsulation SiO outlayer containing ‐S‐S‐ bonds) demonstrates enhanced ferroptosis. tumor‐bearing mice models shows exhibited biocompatibility tumor inhibition effect (inhibition 73%), improve overall survival 30 days post‐treatment. This study will provide an innovative way design therapeutic nanoagents cancer treatments.

Language: Английский

Joule heating synthesis for single-atomic Fe sites on porous carbon spheres and armchair-type edge defect engineering dominated oxygen reduction reaction performance DOI
Yifei Liu,

Lingbo Zong,

Yuanyuan Zhang

et al.

Applied Catalysis B Environment and Energy, Journal Year: 2024, Volume and Issue: unknown, P. 124673 - 124673

Published: Oct. 1, 2024

Language: Английский

Citations

8
Engineering of N doped carbon@FeCo alloy hollow spheres: Remarkable mid-frequency electromagnetic wave absorption performance exhibited by unique porous and wrinkled surface structure DOI
Jiyuan Xiao, Bo Wen, Jiatian Li

et al.

Journal of Alloys and Compounds, Journal Year: 2024, Volume and Issue: 1008, P. 176595 - 176595

Published: Sept. 19, 2024

Language: Английский

Citations

3
A pH/GSH Dual‐Responsive Triple Synergistic Bimetallic Nanocatalyst for Enhanced Tumor Chemodynamic Therapy DOI Open Access
Lu Zhang,

Huan Shen,

Tingting Liu

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Abstract Chemodynamic therapy (CDT) has garnered significant attention in the field of tumor due to its ability convert overexpressed hydrogen peroxide (H 2 O ) tumors into highly toxic hydroxyl radicals (•OH) through metal ion‐mediated catalysis. However, effectiveness CDT is hindered by low catalyst efficiency, insufficient intra‐tumor H level, and excessive glutathione (GSH). In this study, a pH/GSH dual responsive bimetallic nanocatalytic system (CuFeMOF@GOx@Mem) developed modifying red blood cell membranes onto glucose oxidase (GOx)‐loaded Fe‐Cu MOFs, enhancing efficacy triple‐enhanced way self‐supply, catalysts self‐cycling, GSH self‐elimination. Upon accumulation tissues facilitated membrane, GOx initiates reaction with generate gluconic acid situ. Subsequently, reduced pH triggers release Fe 3+ Cu 2+ from CuFeMOF@GOx@Mem, which immediately turned + GSH, activating ‐mediated Fenton reaction. More importantly, can also act as an accelerator /Fe conversion, meanwhile, generated be further GSH. Consequently, sustained well elimination are achieved simultaneously, providing unique approach for improving anti‐tumor CDT.

Language: Английский

Citations

0
Ultrasmall Hydrophilic Gd‐Free Contrast Agents via Ligand Directed Hydrolysis for Efficient Magnetic Resonance Imaging DOI Open Access
Ma Qian,

Yiting Luo,

Yuyan Li

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 21, 2025

Abstract A Mn‐anchored ultrasmall hydrophilic TiO 2 based contrast agent (TMn‐PMM) is prepared via ligand directed hydrolysis with high relaxivity (71.4 mM −1 s under 0.5 T, which 16.7 times higher than that of commercial Gd‐contrast agents). Results indicate the presences ligands (oleylamine/oleic acid) tend to obtain degree crystallinity even after removal by etching, lead less surface oxygen vacancy obtained ethanol. The well‐dispersed Mn sites and rich hydroxyl groups (O─H) in TMn‐PMM significantly increase effective active for interaction surrounding water protons, addition extending rotational correlation time ( τ R ), thus, affording satisfied magnetic resonance imaging (MRI) performance vivo. Moreover, size zwitterionic polymer coating ensure excellent biocompatibility desirable body clearance.

Language: Английский

Citations

0
Recent progress in the rational design and applications of nanozymes DOI Creative Commons
Yutian Zhang, Qi Zhao, Min Zhang

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: 2(1), P. 25 - 38

Published: March 1, 2025

Language: Английский

Citations

0
Diagnosis of Metastatic Breast Tumor with an Iron-Based Hydrogen-Bonded Organic Framework via T2-Weighted Magnetic Resonance Imaging DOI
Xiang Zhou, Nan Zhang,

Sixue Ouyang

et al.

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 19, 2025

Magnetic resonance imaging (MRI) often employs contrast agents (CAs) to improve the visualization of lesions. Although iron-based oxides have been clinically approved as T2 CAs, various obstacles hindered their widespread commercial use. Consequently, there is a pressing demand for innovative T2-type CAs. Herein, we synthesized an hydrogen-bonded organic framework (Fe-HOF) from Fe-TCPP and explored its potential T2-weighted MRI CA. The Fe-HOF demonstrated superior relaxivity (r2) 32.067 mM–1 s–1 higher r2/r1 ratio 45.25 compared Fe-TCPP. This enhancement may be attributed combination single-atom form Fe3+ with increased radius. Our findings indicate that 6 μmol [Fe]/kg dose significantly improves lesion in scans subcutaneous tumor model mice liver metastasis breast tumor. simplicity Fe-HOF' s structure ensures absence complex metal ions or ligands during synthesis, iron component can metabolized into endogenous pool, resulting remarkable biocompatibility biosafety. These pave way design novel probes tailored cancer characterization at stages.

Language: Английский

Citations

0
ATP‐Triggered Ultrafine Iron Oxide Nanowires for Self‐Monitoring Tumor Therapy by T1‐Magnetic Resonance Imaging‐Guided •OH Generation DOI
Zhengtao Xu,

Chen Wang,

Zhuangzhuang Zhao

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 13, 2025

Abstract Theranostic probes that integrate diagnosis and treatment together are considered as effective tools for individual therapy. However, the separation of detection components limits precise assessment therapeutic efficacy. Herein, a novel self‐monitoring probe sensitively responds to adenosine triphosphate (ATP) was developed by ultrafine iron oxide nanowires (UIONWs) through an oleyl amine‐assisted way. The UIONWs, with diameter 1.5 nm length 75 nm, surface‐coordinated amine. UIONWs can be decomposed in ATP‐containing solution expose shielded ions. Consequently, it boost peroxidase (POD) activity activate T 1 ‐magnetic resonance imaging (MRI) signal ATP. In addition, rapidly engulfed into cells due high aspect ratio. improved ATP hydrogen peroxide (H 2 O ) within tumor leads higher hydroxyl radicals (OH) generation inhibition.In contrast, normal exhibit lower H levels, reducing cytotoxicity ensuring safety. Since both illumination ‐MRI OH ATP‐controlled, this work raised potential way self‐monitor therapy timely feedback on effects.

Language: Английский

Citations

0
Supramolecular Nanoplatforms with Activable Ultrasound and Magnetic Resonance Imaging for Cancer Diagnosis and Therapy DOI

Taoxia Liu,

Fanqi Liu,

Xindi Li

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Abstract Excellent multifunctional platforms for cancer diagnosis and treatment are highly desirable. Herein, nanocomposites constructed by utilizing Mn 2+ to coordinate the imidazole moiety anchored on CuO 2 nanoparticles through cyclodextrin‐adamantane interaction. The encapsulated (NPs) can generate hydrogen peroxide (H O ) at tumor sites under acidic conditions upon decomposition, which is further turned into oxygen (O catalysis, facilitating both ultrasound magnetic resonance imaging (MRI). Moreover, proposed nanomedicine enhances reactive species (ROS) generation depletes glutathione (GSH), leading increased lipid peroxidation (LPO) effective ferroptosis‐mediated therapy. Such a strategy presents promising approach development of theranostics imaging‐guided

Language: Английский

Citations

0
A pH/STEAP Cascade‐Responsive Nanomedicine with Self‐Supplied Peroxide for Precise Chemodynamic Therapy DOI

Huilan Cai,

Shenghan Chen,

Zhu Yang

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

Abstract Self‐supply of peroxo compounds has been regarded as a promising strategy to enhance Fenton chemistry‐based chemodynamic therapy (CDT). However, the inherent selectivity CDT will be affected after introducing peroxide‐supplementing functionality into agents due lack ability distinguish cancer cells from normal cells. Here, an intelligent nanomedicine is reported with both cascade‐responsive and peroxide self‐supplying performances for specific efficient treatment. Upon endocytosis acidic endo/lysosomes, comprising methyl linoleate hydroperoxide (MLH)‐loaded amorphous iron oxide nanoparticles (AIO@MLH NPs) can decomposed release MLH Fe 3+ that further reduced 2+ by endo/lysosomal six‐transmembrane epithelial antigen prostate (STEAP) metalloreductase activity, enabling occurrence Fenton‐type reaction between high‐active free radical generation, which causes damage cell apoptosis. Noteworthily, AIO@MLH NPs exhibit potent cytotoxicity cancerous rather than non‐cancerous benefiting overexpressed STEAP in multiple cancers, thereby leading precise tumor CDT. This work highlights use endogenous improve paves way development precision medicine.

Language: Английский

Citations

0
Manganese-Based Natural Photosensitive Protein Nanocomplex for Image-Guided Multimodal Synergistic Cancer Therapy DOI
Di Yang, Danni Zhong, Ruoxi Wang

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: May 6, 2025

Photodynamic therapy (PDT) is widely utilized in cancer treatment as a noninvasive strategy. Phycocyanin (PC), natural water-soluble photosensitizer with nontoxic properties, shows promise PDT candidate. However, the limitations of PC when used alone for treatment, such inadequate tumor delivery and weak efficacy, must be addressed. Herein, an efficient theranostic manganese (Mn)-based nanocomplex (PC@Mn) was synthesized through straightforward one-pot self-assembly reaction synergistic antitumor therapy. The PC@Mn nanoparticles were found to have suitable size (∼129 nm) demonstrated excellent biocompatibility biosafety. Importantly, these exhibited enhanced biodistribution improved targeting retention properties. When combined 650 nm laser irradiation, showed significant enhancement effect vivo. Additionally, displayed promising magnetic resonance (MR) imaging capabilities, high relaxation rate (r1 = 10.14 mM-1 s-1) extended time window (4 h). This feature enables real-time monitoring nanoparticles' distribution within tumors, facilitating precise determination optimal time. Overall, study highlights simple, safe, highly strategy Its ability combine MR guidance represents approach therapeutic outcomes potential clinical applications future.

Language: Английский

Citations

0