Metal–organic frameworks for biological applications

Nature Reviews Methods Primers, Journal Year: 2024, Volume and Issue: 4(1)

Published: June 27, 2024

Language: Английский

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Fabrication of a nano-herbicide QNC@BA-COF with high control efficiency and reduced side effects.

Advanced Agrochem, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

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Inhibition mechanism of Rhizoctonia solani by pectin-coated iron metal-organic framework nanoparticles and evidence of an induced defense response in rice

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 474, P. 134807 - 134807

Published: June 4, 2024

Language: Английский

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Effects of Exposure to Different Types of Metal–Organic Framework Nanoparticles on the Gut Microbiota and Liver Metabolism of Adult Zebrafish

ACS Nano, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 31, 2024

Metal–organic framework nanoparticles (MOF NPs) have received much attention for their potential use in nanopesticides. However, little is known about the health and environmental risks associated with these materials. In this study, toxicological responses of zebrafish exposed to five MOF NPs short long periods time were evaluated. The acute toxicity results showed that embryos adult was order Cu-MOF > ZIF-90 ZIF-8 Fe-MOF Zr-MOF. Histopathological analysis revealed ZIF-8, ZIF-90, caused liver swelling vacuolization zebrafish. cellular ultrastructure severely damaged mitochondrial structure intestinal epithelial cells cells. 16S rDNA sequencing data all significantly altered dominant microorganisms intestine. microbial markers inflammation, Proteobacteria (Aeromonas, Plesiomonas, Legionella), increased Fe-MOF, Zr-MOF, treatment groups. Metabolomics indicated levels inflammatory promoting factors (Leukotriene E4, 20-hydroxyeicosatetraenoic acid) arachidonic acid metabolism decreased, suppressing (8,9-epoxyeicosatrienoic increased. Metabolites related oxidative stress, such as glutamine, pyridoxamine, l-glutamic vitamin B6 other signaling pathways, reduced. Overall, suggest different had widely varying zebrafish, further should be paid real environment.

Language: Английский

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Inhalable Metal–Organic Frameworks: A Promising Delivery Platform for Pulmonary Diseases Treatment

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

Inhalation delivery, offering a direct pathway for administering drugs to the lungs in form of dry powders or aerosols, stands out as an optimal approach localized treatment pulmonary diseases. However, intricate anatomical architecture lung often poses challenges maintaining effective drug concentrations within over extended periods. This highlights pressing need develop rational inhalable delivery systems that can improve outcomes respiratory Metal-organic frameworks (MOFs) assembled from inorganic metal ions and organic ligands, characterized by customizable porous chemical composition, modifiable porosity, vast surface area, straightforward modification, adjustable biocompatibility, have garnered extensive attention biomedical sphere. The introduction MOFs into inhalation therapy represents promising avenue navigate past hurdles associated with traditional methods. Therefore, this review summarizes characteristics together latest advances, challenges, opportunities utilizing treating diseases discusses prospects field alongside potential pathways translating strategy clinic.

Language: Английский

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An eco-friendly bimetallic dual-pesticide metal–organic framework nanocomposite for synergistic control of grey mold

Journal of environmental chemical engineering, Journal Year: 2025, Volume and Issue: unknown, P. 115892 - 115892

Published: Feb. 1, 2025

Language: Английский

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Combined application of surfactants and iron-based metal–organic framework nanoparticles for targeted delivery of insecticides

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 488, P. 151193 - 151193

Published: April 10, 2024

Language: Английский

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Mesoporous silica nanoparticles based on a dual environmental response corresponding to temperature and α-amylase for the control of Spodoptera litura

Industrial Crops and Products, Journal Year: 2024, Volume and Issue: 222, P. 119526 - 119526

Published: Aug. 31, 2024

Language: Английский

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Discovery of New Benzohydrazide Derivatives Containing 4-Aminoquinazoline as Effective Agricultural Fungicides, the Related Mechanistic Study, and Safety Assessment

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 23, 2025

A total of 38 new benzohydrazide derivatives bearing the 4-aminoquinazoline moiety were designed and synthesized based on active subunit combination approach tested in detail for their inhibition activities against eight agricultural phytopathogenic fungi. The bioassay results indicated that many compounds exhibited extraordinary fungicidal vitro For example, A5, A6, A11, A17 had EC50 (half-maximal effective concentration) values 0.66, 0.71, 0.40, 0.42 μg/mL Colletotrichum gloeosporioides, respectively, comparable to boscalid (0.36 μg/mL) much superior carbendazim (6.96 μg/mL). Of particular importance was compound A6 with a 3,4-difluorophenyl group found possess good broad-spectrum antifungal effects, ranging from 0.63 3.82 In vivo assays also revealed curative protective efficacies 72.6% 78.9% at 200 Rhizoctonia solani-caused rice sheath blight, higher than those (70.7 65.2%, respectively). Moreover, mechanism-of-action studies disrupted cell membrane integrity R. solani, as proved by relative conductivity measurements, leakage cellular contents, fluorescence microscopy, scanning electron microscopy observations. Significantly, this an succinate dehydrogenase (SDH) solani inhibitory concentration/IC50 = 11.02 μM), slightly weaker SDH inhibitor (5.17 μM). Further molecular docking analysis could form strong interactions key residues enzyme via hydrogen bond, electrostatic, π-cation interactions, holding promise acting fungicide leads targeting SDH. Finally, safety assessments safe honeybees.

Language: Английский

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Two Birds with One Stone: Eco‐Friendly Nano‐Formulation Endows a Commercial Fungicide with Excellent Insecticidal Activity

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Abstract The development of multi‐action pesticides presents significant advantages, including cost‐effectiveness, reduced application frequency, enhanced resistance management, and minimized environmental impact. Despite its efficacy in targeting chitin synthase both fungi insects, the insecticidal performance polyoxin B remains limited. To overcome this limitation, a novel nano‐formulation, B@ZTS is developed, utilizing agricultural byproducts, tea saponin, zein. This formulation features small particle size, high leaf deposition efficiency, excellent dispersion properties. Leveraging disulfide bond system, designed to respond intracellular reducing environment, enabling controlled release B. Remarkably, nano‐formulation facilitates penetration physiological barriers, achieving equivalent fungicidal at only one‐fifth dosage. work highlights potential eco‐friendly, cost‐effective, multifunctional nano‐pesticides, providing compelling solution for sustainable practices demonstrating broad applicability integrated pest disease management.

Language: Английский

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