Molecular Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
21(9), P. 4498 - 4509
Published: July 29, 2024
Recent
emphasis
on
the
design
of
drug
delivery
systems
typically
involves
effective
transport
a
pharmaceutical
substance
to
disease
site
with
desired
therapeutic
efficacy
and
minimal
cytotoxicity.
Organelle-targeted
peptides
have
become
an
integral
part
designing
important
class
prodrug/prodrug
assemblies
for
new
supramolecular
therapeutics
owing
their
favorable
biocompatibility,
synthetic
ease,
tunability
aggregation
behavior,
functionalization
site-specificity.
However,
it
is
still
limited
due
low
selectivity.
We
designed
folic
acid-functionalized
β-cyclodextrin
(FA-CD)
as
platform
specific
selective
organelle-targeted
(such
microtubule,
lysosome,
mitochondria)
peptide
chemotherapeutics
folate
receptor
(FR)
overexpressing
cancer
cell
lines.
Low
toxicity
was
found
FA-CD
inclusion
complex
in
FR-negative
normal
cells,
but
superior
inhibition
tumor
growth
no
vivo
xenograft
model.
ACS Applied Bio Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 30, 2025
Cuproptosis
exhibits
enormous
application
prospects
in
treatment.
However,
cuproptosis-based
therapy
is
impeded
by
the
limited
intracellular
copper
ions,
nonspecific
delivery,
uncontrollable
release,
and
chelation
of
endogenous
overproduced
glutathione
(GSH).
In
this
work,
an
ultrasound-triggered
nanosonosensitizer
(p-TiO2–Cu(I))
was
constructed
for
Cu(I)
on-demand
GSH
consumption,
deeper
tissue
response.
When
nanomedicine
internalized
into
tumor
cells,
ultrasound
(US)
induced
to
produce
reactive
oxygen
species
(ROS)
achieve
sonodynamic
(SDT).
GSH,
acting
as
a
hole
trapping
agent,
improved
efficiency
SDT.
Meanwhile,
downgrade
beneficial
cuproptosis
oxidative
damage-based
SDT
return.
What
more,
US
could
regulate
release
behavior
Cu(I).
bonded
mitochondrial
proteins
then
aggregated
lipoylated
protein,
bringing
about
turbulence
tricarboxylic
acid
cycle.
The
combination
showed
high
matching
induce
efficient
may
inspire
other
designs.
Effective
management
of
inflammation
is
one
the
promising
strategies
to
prevent
formation
chronic
wounds.
Despite
hydrogen
being
a
prospective
molecule
for
anti-inflammatory
effects,
on-demand
delivery
that
could
synchronize
with
dynamic
stages
has
yet
remained
unaddressed.
Moreover,
its
specific
immunomodulatory
mechanisms
are
still
veiled.
In
this
study,
we
introduced
ISO-ZIF-8@AB,
hydrogen-generating
nanoplatform
integrated
visible-light
photocatalysis
and
hydrolysis
reactions
achieve
controllable
release
on
demand,
functioning
an
initial
peak
following
sustained
release.
With
ISO-ZIF-8@AB
further
loaded
into
aligned
ECM-like
scaffold,
complex
significantly
alleviated
prevented
protracted
unhealing.
The
bulk-RNA
sequencing
combined
single-cell
RNA
revealed
treatment
effectively
reduced
excessive
aggregation
infiltration
innate
immune
cells.
Specifically,
proportion
Ptgs2+Nos2+
pro-inflammatory
macrophages
(PIMs)
by
mitigating
mitochondrial
stress
suppressing
HIF-1α-induced
glycolysis,
immune-metabolic
regulation
which
harmful
crosstalk
between
PIMs
hypodermal
fibroblasts
facilitated
extracellular
matrix
production
accompanied
ultimate
wound
repair.
Overall,
study
presented
strategy
in
terms
timing
rate,
discussions
regarding
underlying
therapy.
ACS Omega,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 28, 2025
This
article
reports
the
synthesis,
characterization,
and
antitumor
properties
of
newly
synthesized
benzimidazole-based
Ag(I)-(BNHCs)
complexes
from
their
proligands.
All
compounds
underwent
comprehensive
characterization
using
techniques
such
as
1H,
COSY,
13C
NMR,
IR
spectroscopy,
electrospray
ionization
(ESI)-mass,
elemental,
single-crystal
X-ray
diffraction
(XRD)
analysis.
Density
functional
theory
(DFT)
studies
were
carried
out
to
observe
electronic
effects
bound
ligands
modulate
selectivity
reactivity
silver
complexes.
Time-dependent
DFT
(TD-DFT)
assessed
optical
further
highlighted
by
orbital
contributions
with
oscillator
strengths.
tested
against
breast
cancer
MCF-7
T47D
cell
lines.
The
synergistic
benzimidazole-incorporated
aryl
constituent
structuring
also
observed.
Nearly
all
have
been
found
be
promising
anticancer
agents
added
benefit
low
cytotoxic
toward
normal
cells.
Intriguingly,
[AgL
4
(Cl)]
exhibited
best
activity
among
our
screened
IC50
values
for
both
9
±
1.04
11
1.41,
respectively.
apoptosis
mode
death
was
confirmed
phosphatidylserine
exposure
annexin
V/PI
staining
imaging
method.
CT-DNA
interactions
most
active
complex
([AgL
(Cl)])
its
proligand
(HL
(Cl))
support
compound-DNA
interaction.
Strong
DNA
binding
affinities
(K
b)
through
electrostatic
intercalation
modes
induced
structural
changes
in
DNA.
Moreover,
molecular
docking
comprehend
possible
various
receptors
EGFR
(epidermal
growth
factor
receptor),
VEGFR2
(vascular
endothelial
receptors),
FGFR
(fibroblast
SRC
(proto-oncogene
tyrosine
kinase
protein)
family
serves
crucial
cancer.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2025,
Volume and Issue:
13
Published: May 1, 2025
Despite
the
success
in
exploring
various
aspects
of
origination
and
therapeutic
strategies,
cancer
has
remained
one
most
dreadful
metabolic
disorders
due
to
failure
eradicate
tumors
comprehensively
frequent
recurrence
because
acquired
resistance
drugs.
Recently,
several
advancements
have
been
evidenced
fabrication
smart
nanocarriers
encapsulated
with
multiple
components.
Several
reasons
for
nanoencapsulation
include
enhancement
bioavailability
drugs,
precise
targetability
reduce
adverse
effects
on
normal
cells,
ability
enable
controlled
drug
release
rates
at
tumor
sites.
In
addition,
these
protect
cargo
from
deactivation,
responsively
delivering
it
based
physiological
or
pathological
characteristics
tumors.
this
review,
we
present
approaches
therapy,
including
organic
materials,
inorganic
components,
their
composites,
as
well
biomembrane-based
strategies.
These
along
practical
applications
potential
treatment,
are
discussed
depth,
highlighting
advantages
disadvantages,
aiming
reveal
ultimate
prospects
enhancing
delivery
efficiency
targeted
therapy.
Polymersomes
are
nanostructures
consisting
of
a
hollow
aqueous
compartment
enclosed
by
coating
amphiphilic
block
copolymers.
Owing
to
the
entangled
nature
their
membrane,
polymersomes
exhibit
higher
mechanical
stability
than
some
other
extensively
studied
such
as
liposomes.
This
also
enables
properties
polymersome
membrane
be
more
easily
tuned
meet
practical
needs,
making
promising
carriers
for
drug
delivery.
Since
turn
last
century,
use
has
been
exploited
in
diverse
areas,
ranging
from
protein
therapy
medical
imaging.
Yet,
discussions
exploring
opportunities
and
challenges
development
oral
administration
have
scant.
review
addresses
this
gap
offering
snapshot
current
advances
design,
fabrication,
carriers.
It
is
hoped
that
will
not
only
highlight
potential
but
shed
light
on
determining
wider
clinical
forthcoming
decades.
Nanoscale,
Journal Year:
2024,
Volume and Issue:
16(34), P. 15967 - 15983
Published: Jan. 1, 2024
The
CCTH
nanoparticles
trigger
power
coalescence
and
death
vortex
within
tumor
cell
mitochondria,
producing
potent
anti-tumor
efficacy
through
cuproptosis/phototherapy/chemotherapy
synergistic
therapy.
