Biomaterials, Journal Year: 2024, Volume and Issue: 315, P. 122971 - 122971
Published: Nov. 19, 2024
Language: Английский
Biomaterials, Journal Year: 2024, Volume and Issue: 315, P. 122971 - 122971
Published: Nov. 19, 2024
Language: Английский
Small, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 15, 2024
Abstract The treatment of brain diseases has always been the focus attention. Due to presence blood‐brain barrier (BBB), most small molecule drugs are difficult reach brain, leading undesirable therapeutic outcomes. Recently, nanomedicines that can cross BBB and precisely target lesion sites have emerged as thrilling tools enhance early diagnosis treat various intractable disorders. Extensive research shown reactive oxygen species (ROS) play a crucial role in occurrence progression diseases, including tumors neurodegenerative (NDDs) such Alzheimer's disease, Parkinson's stroke, or traumatic injury, making ROS potential target. In this review, on structure function well mechanisms first elaborated through which nanomedicine traverses it. Then, recent studies production summarized photodynamic therapy (PDT), chemodynamic (CDT), sonodynamic (SDT) for treating tumors, depletion NDDs. This provides valuable guidance future design ROS‐targeted disease treatment. ongoing challenges perspectives developing nanomedicine‐based management also discussed outlined.
Language: Английский
Citations
2Published: Jan. 1, 2024
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Language: Английский
Citations
1Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 495, P. 153368 - 153368
Published: June 21, 2024
Language: Английский
Citations
1Molecular Pharmaceutics, Journal Year: 2024, Volume and Issue: 21(9), P. 4498 - 4509
Published: July 29, 2024
Recent emphasis on the design of drug delivery systems typically involves effective transport a pharmaceutical substance to disease site with desired therapeutic efficacy and minimal cytotoxicity. Organelle-targeted peptides have become an integral part designing important class prodrug/prodrug assemblies for new supramolecular therapeutics owing their favorable biocompatibility, synthetic ease, tunability aggregation behavior, functionalization site-specificity. However, it is still limited due low selectivity. We designed folic acid-functionalized β-cyclodextrin (FA-CD) as platform specific selective organelle-targeted (such microtubule, lysosome, mitochondria) peptide chemotherapeutics folate receptor (FR) overexpressing cancer cell lines. Low toxicity was found FA-CD inclusion complex in FR-negative normal cells, but superior inhibition tumor growth no vivo xenograft model.
Language: Английский
Citations
1Biomaterials, Journal Year: 2024, Volume and Issue: 315, P. 122971 - 122971
Published: Nov. 19, 2024
Language: Английский
Citations
1