R-Q@P-D nanoparticle for improving the oral bioavailability and therapeutic efficacy: A novel reversible dual-target-mild-inhibition intestinal metabolic enzymes strategy for resveratrol delivery DOI

Qingchen Cui,

Yanling Li,

Liping Zhou

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 497, P. 154662 - 154662

Published: Aug. 11, 2024

Language: Английский

OGG1: An emerging multifunctional therapeutic target for the treatment of diseases caused by oxidative DNA damage DOI Creative Commons

Yunxiao Zhong,

Xinya Zhang, Ruibing Feng

et al.

Medicinal Research Reviews, Journal Year: 2024, Volume and Issue: 44(6), P. 2825 - 2848

Published: Aug. 9, 2024

Oxidative DNA damage-related diseases, such as incurable inflammation, malignant tumors, and age-related disorders, present significant challenges in modern medicine due to their complex molecular mechanisms limitations identifying effective treatment targets. Recently, 8-oxoguanine glycosylase 1 (OGG1) has emerged a promising multifunctional therapeutic target for the of these challenging diseases. In this review, we systematically summarize multiple functions OGG1, including pro-inflammatory, tumorigenic, aging regulatory mechanisms. We also highlight potential OGG1 inhibitors activators potent agents aforementioned life-limiting conclude that serves hub; inhibition may provide novel approach preventing treating inflammation cancer, activation could be strategy disorders. Furthermore, an extensive overview successful applications regulation inflammatory, cancerous, aging-related Finally, discuss current future directions emerging marker The aim review is robust reference scientific researchers clinical drug developers development targeted drugs especially

Language: Английский

Citations

9
Bioactive Decellularized Extracellular Matrix Platform Integrating Multifunctional Nanozymes and Cell-Laden Microgels for Acute Liver Failure Treatment DOI
Gang Xiao, Jiabin Zhang,

Tong Lin

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Mesenchymal stem cell (MSC) therapy has emerged as a promising alternative approach for treating acute liver failure (ALF) while confronting the shortage of low efficiency and poor engraftment within hostile milieu. In this study, we establish bioactive decellularized extracellular matrix (dECM) platform that incorporates dihydrolipoic acid (DHLA)-protected Pt nanoclusters doped with Cu (PtCu-DHLA) nanozymes cell-laden microgels. The PtCu-DHLA nanozymes, selected their versatility, function antioxidant, anti-inflammatory, pro-proliferative, pro-angiogenic agents, enhancing ALF alleviation providing an optimal microenvironment MSC transplantation. Additionally, methacrylic anhydride (MA)-modified porcine liver-derived (PLdECM) hydrogel (PLdECMMA) been developed construction microgels via microfluidic devices. Interferon γ (IFNγ) preconditioned MSCs encapsulated in PLdECMMA exhibit enhanced immunomodulating activity prolonged survival. are codelivered by leveraging PLdECM orthotopic transplanted dECM enables efficient successful rescue CCl4-induced counteracting oxidative stress, suppressing inflammatory storms, promoting cellular regeneration. Overall, study highlights synergistic reinforced strategy combines biomimetic therapy, offering significant potential treatment broader applications regenerative medicine.

Language: Английский

Citations

1
Fully Bioactive Nanodrugs: Stem Cell-Derived Exosomes Engineered with Biomacromolecules to Treat CCl4- and Extreme Hepatectomy-Induced Acute Liver Failure DOI
Meng Sun, Min Li, Min Hu

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(50), P. 33907 - 33921

Published: Dec. 3, 2024

Acute liver failure (ALF) is a serious global disease characterized by rapid onset and high mortality. Currently, the clinical treatment of ALF faces considerable hurdles due to limited medication options scarcity transplants. Despite biomacromolecules such as hepatocyte growth factor (HGF) glutathione (GSH) having been applied for symptom relief in clinic, they still face substantial challenges including poor stability, difficulty acting on intracellular targets, inadequate therapeutic outcome. In this work, taking advantage innate targeting regenerative capabilities mesenchymal stem cells (MSCs), we harnessed MSC-derived exosomes natural bioactive carriers simultaneous delivery HGF GSH, forming fully nanodrug termed HG@Exo. Impressively, HG@Exo demonstrated potent effects against both carbon tetrachloride (CCl

Language: Английский

Citations

4
Biomimetic bioreactor for potentiated uricase replacement therapy in hyperuricemia and gout DOI Creative Commons
Bin Yang,

Guihu Luo,

Ting Nie

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 7, 2025

Uricase replacement therapy is a promising approach for managing hyperuricemia and gout but hindered by challenges such as short blood circulation time, reduced catalytic activity, excessive hydrogen peroxide (H2O2) production. These limitations necessitate innovative strategies to enhance therapeutic efficacy safety. We designed synthesized RBC@SeMSN@Uri, red cell-coated biomimetic self-cascade bioreactor, which encapsulates uricase (Uri) selenium-based nano-scavenger (SeMSN) within RBC membranes. This design aims reduce immunogenicity, extend systemic circulation, maintain enzymatic activity. In vitro assays were conducted evaluate biocompatibility, anti-inflammatory effects, oxidative stress protection. vivo experiments in models assessed efficacy, biodistribution, biosafety. RBC@SeMSN@Uri effectively degraded uric acid (UA) into allantoin converted H2O2 water, preventing damage inflammation. demonstrated excellent biocompatibility H2O2-induced inflammatory responses compared free uricase. vivo, the bioreactor prolonged significantly levels, alleviated kidney damage, mitigated symptoms of gout. It also targeted inflamed joints, reducing swelling inflammation gouty arthritis models. study presents novel strategy enzyme By integrating membranes, addresses key traditional therapies, offering enhanced stability, superior efficacy. platform holds potential broader applications protein or antibody delivery therapies other diseases.

Language: Английский

Citations

0
Mesenchymal stromal/stem cell spheroid-derived extracellular vesicles advance the therapeutic efficacy of 3D-printed vascularized artificial liver lobules in liver failure treatment DOI
Jiabin Zhang,

Xiaodie Chen,

Yurong Chai

et al.

Bioactive Materials, Journal Year: 2025, Volume and Issue: 49, P. 121 - 139

Published: March 6, 2025

Language: Английский

Citations

0
Neutrophil membrane engineered human umbilical cord MSC-derived sEVs enhance anti-tumor efficacy for gastric cancer via delivering pentraxin 3 DOI
Yuting Tang, Ye Shen,

Xueyan Zang

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113828 - 113828

Published: May 1, 2025

Language: Английский

Citations

0
Nanoscale synthetic biology with innovative medicinal applications DOI Creative Commons
Jingsen Ji, Li Li,

Weisheng Guo

et al.

Fundamental Research, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

Citations

2
R-Q@P-D nanoparticle for improving the oral bioavailability and therapeutic efficacy: A novel reversible dual-target-mild-inhibition intestinal metabolic enzymes strategy for resveratrol delivery DOI

Qingchen Cui,

Yanling Li,

Liping Zhou

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 497, P. 154662 - 154662

Published: Aug. 11, 2024

Language: Английский

Citations

0