ACS Materials Letters,
Journal Year:
2024,
Volume and Issue:
7(1), P. 1 - 23
Published: Nov. 21, 2024
With
the
continuous
increase
in
average
life
expectancy,
population
aging
has
become
a
significant
health
issue
21st
century.
The
rising
prevalence
of
age-related
diseases
brought
tremendous
pressure
on
social
medical
systems
and
economy.
Against
this
backdrop,
research
anticellular
hot
spot
field
biomedicine,
biomaterials
are
showing
new
trends
potential
area.
Compared
to
drugs
other
traditional
anti-aging
strategies,
can
be
personalized
target
characteristics
different
tissues,
serving
as
drug
delivery
carriers
enhance
targeting,
directly
influence
cellular
process
by
modulating
microenvironment.
Furthermore,
offer
innovative
approaches
diagnosing
building
sophisticated
models,
which
our
understanding
biology
behind
speed
up
advancement
novel
treatments.
This
review
synthesizes
latest
advancements
biomaterial
for
combating
aging,
exploring
future
prospects
challenges.
Analytical Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 19, 2025
The
wash-free
method
represents
a
promising
strategy
for
enhancing
the
detection
efficiency
of
automated
chemiluminescent
(CL)
immunoassay
analyzers.
Herein,
novel
separation-free
and
was
developed
first
time
based
on
distance-driven
CL
technique.
In
immunoassay,
well-designed
Au–Co
metal
nanoclusters
(NCs)
exhibited
excellent
peroxidase-like
activity
good
stability,
allowing
efficient
catalysis
luminol
or
its
analogue
(ABEI)-H2O2
system
even
at
low
concentrations.
Furthermore,
large
specific
surface
area
NCs
facilitated
accommodation
greater
number
antibodies,
thereby
capture
antigens
achieving
dual
amplification
signal.
technique
relied
formation
sandwich-type
immunocomplexes.
Upon
generation
hydroxyl
radicals
superoxide
anion
through
catalytic
decomposition
H2O2
by
NCs,
ABEI
within
immunocomplexes
could
efficiently
react
with
these
radicals,
leading
to
significant
enhancement
in
signals.
C-reactive
protein
(CRP)
chosen
as
model
analyte
evaluate
practicability
proposed
immunoassay.
Notably,
presented
high
sensitivity,
selectivity,
reproducibility,
successfully
determining
CRP
serum
samples
recoveries
96.55–106.29%.
Accordingly,
advantage
separation-free,
wash-free,
reliable
characteristics
drastically
simplify
operation
steps
enhance
efficiency,
which
would
make
advances
revolution
traditional
Analytical Chemistry,
Journal Year:
2024,
Volume and Issue:
96(35), P. 14283 - 14290
Published: Aug. 23, 2024
Innovative
signal
amplification
and
transduction
play
pivotal
roles
in
bioanalysis.
Herein,
cascading
CRISPR/Cas
the
nanozyme
are
integrated
with
electronic
an
organic
photoelectrochemical
transistor
(OPECT)
to
enable
triple
amplification,
which
is
exemplified
by
miRNA-triggered
CRISPR/Cas13a
system
polyoxometalate
for
OPECT
detection
of
miRNA-21.
The
CRISPR/Cas13a-enabled
release
glucose
oxidase
could
synergize
peroxidase-like
SiW12
induce
catalytic
precipitation
on
photogate,
inhibiting
interfacial
mass
transfer
thus
significant
suppression
channel
current.
as-developed
sensor
demonstrates
good
sensitivity
selectivity
miRNA-21
detection,
a
linear
range
from
1
fM
10
nM
ultralow
limit
0.53
fM.
This
study
features
integration
bio-
nanoenzyme
cascade
detection.
ACS Materials Au,
Journal Year:
2025,
Volume and Issue:
5(2), P. 377 - 384
Published: Jan. 31, 2025
Single-atom
nanozymes
(SANs)
are
a
class
of
with
metal
centers
that
mimic
the
structure
metalloenzymes.
Herein,
we
report
synthesis
Zn–N–C
SAN,
which
mimics
action
natural
carbonic
anhydrase
enzyme.
The
two-step
annealing
technique
led
to
content
more
than
18
wt
%.
Since
act
as
active
sites,
this
high
loading
resulted
in
superior
catalytic
activity.
Zn-SAN
showed
CO2
uptake
2.3
mmol/g
and
final
conversion
bicarbonate
91%.
was
converted
via
biomimetic
process
by
allowing
its
adsorption
catalyst,
followed
addition
catalyst
HEPES
buffer
(pH
=
8)
start
into
HCO3–.
Afterward,
CaCl2
added
form
white
CaCO3
precipitate,
then
filtered,
dried,
weighed.
Active
carbon
MCM-41
were
used
controls
under
same
reaction
conditions.
According
findings,
sequestration
capacity
42
mg
CaCO3/mg
Zn-SAN.
Some
amino
acids
(AAs)
binding
affinity
for
Zn
able
suppress
enzymatic
activity
blocking
centers.
This
strategy
detection
His,
Cys,
Glu,
Asp
limits
0.011,
0.031,
0.029,
0.062
μM,
respectively,
hence
utilized
quantifying
these
AAs
commercial
dietary
supplements.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 10, 2024
The
World
Health
Organization
has
warned
that
without
effective
action,
deaths
from
drug-resistant
bacteria
can
exceed
10
million
annually,
making
it
the
leading
cause
of
death.
Conventional
antibiotics
are
becoming
less
due
to
rapid
bacterial
drug
resistance
and
slowed
new
antibiotic
development,
necessitating
strategies.
Recently,
materials
with
catalytic/enzymatic
properties,
known
as
nanozymes,
have
been
developed,
inspired
by
natural
enzymes
essential
for
eradication.
Unlike
recent
literature
reviews
broadly
cover
nanozyme
design
biomedical
applications,
this
review
focuses
on
latest
advancements
in
nanozymes
combating
resistance,
emphasizing
their
design,
structural
characteristics,
applications
combination
therapy,
future
prospects.
This
approach
aims
promote
development
especially
towards
clinical
translation.
IntechOpen eBooks,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 27, 2025
Protein-based
biomaterials
are
increasingly
recognized
for
their
pivotal
role
in
tissue
engineering
and
regenerative
medicine
due
to
superior
biocompatibility,
biodegradability,
bioresorbability.
This
chapter
explores
the
development
application
of
protein-based
that
enhance
cell
proliferation,
adhesion,
integration
with
native
tissues
support
regeneration.
The
present
book
outlines
different
types
proteins
used
as
elucidates
mechanisms
action
By
utilizing
advanced
fabrication
techniques
such
electrospinning,
3D
bioprinting,
encapsulation
adsorption
methods,
biomimetic
scaffolds
replicate
extracellular
matrix
(ECM)
can
be
created
delivery
systems
therapeutic
stability
efficacy
developed.
In
addition,
addresses
critical
challenges
associated
extensive
defects,
offering
promising
advancements
fields
medicine.
