Facile construction of Mo-based nanozyme system via ZIF-8 templating with enhanced catalytic efficiency and antibacterial performance DOI Creative Commons
Haoruo Jia,

Ziyuan Zheng,

Jining Qu

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(18), P. e38057 - e38057

Published: Sept. 1, 2024

Language: Английский

Metal-Phenolic Chemistry Mediates Assembly of Single-Atom Nanozymes for Cancer Therapy DOI
Zhiliang Gao,

Hongning Sun,

Hao‐Xin Liu

et al.

Chemistry of Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 23, 2025

Language: Английский

Citations

2
Cascading CRISPR/Cas and Nanozyme for Enhanced Organic Photoelectrochemical Transistor Detection with Triple Signal Amplification DOI
Lin Zhang,

Lu Hou,

Huihui Cai

et al.

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(35), P. 14283 - 14290

Published: Aug. 23, 2024

Innovative signal amplification and transduction play pivotal roles in bioanalysis. Herein, cascading CRISPR/Cas the nanozyme are integrated with electronic an organic photoelectrochemical transistor (OPECT) to enable triple amplification, which is exemplified by miRNA-triggered CRISPR/Cas13a system polyoxometalate for OPECT detection of miRNA-21. The CRISPR/Cas13a-enabled release glucose oxidase could synergize peroxidase-like SiW12 induce catalytic precipitation on photogate, inhibiting interfacial mass transfer thus significant suppression channel current. as-developed sensor demonstrates good sensitivity selectivity miRNA-21 detection, a linear range from 1 fM 10 nM ultralow limit 0.53 fM. This study features integration bio- nanoenzyme cascade detection.

Language: Английский

Citations

9
Zinc Single-Atom Nanozyme As Carbonic Anhydrase Mimic for CO2 Capture and Conversion DOI Creative Commons
Eslam M. Hamed, Fun Man Fung, Sam Fong Yau Li

et al.

ACS Materials Au, Journal Year: 2025, Volume and Issue: 5(2), P. 377 - 384

Published: Jan. 31, 2025

Single-atom nanozymes (SANs) are a class of with metal centers that mimic the structure metalloenzymes. Herein, we report synthesis Zn–N–C SAN, which mimics action natural carbonic anhydrase enzyme. The two-step annealing technique led to content more than 18 wt %. Since act as active sites, this high loading resulted in superior catalytic activity. Zn-SAN showed CO2 uptake 2.3 mmol/g and final conversion bicarbonate 91%. was converted via biomimetic process by allowing its adsorption catalyst, followed addition catalyst HEPES buffer (pH = 8) start into HCO3–. Afterward, CaCl2 added form white CaCO3 precipitate, then filtered, dried, weighed. Active carbon MCM-41 were used controls under same reaction conditions. According findings, sequestration capacity 42 mg CaCO3/mg Zn-SAN. Some amino acids (AAs) binding affinity for Zn able suppress enzymatic activity blocking centers. This strategy detection His, Cys, Glu, Asp limits 0.011, 0.031, 0.029, 0.062 μM, respectively, hence utilized quantifying these AAs commercial dietary supplements.

Language: Английский

Citations

1
Efficient Separation-Free and Wash-Free Immunoassay for Sensitive Detection of Biomarkers Based on the Distance-Driven Chemiluminescent Technique DOI
Xu Teng,

Lingyan Gui,

Weiyuan Liang

et al.

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 19, 2025

The wash-free method represents a promising strategy for enhancing the detection efficiency of automated chemiluminescent (CL) immunoassay analyzers. Herein, novel separation-free and was developed first time based on distance-driven CL technique. In immunoassay, well-designed Au–Co metal nanoclusters (NCs) exhibited excellent peroxidase-like activity good stability, allowing efficient catalysis luminol or its analogue (ABEI)-H2O2 system even at low concentrations. Furthermore, large specific surface area NCs facilitated accommodation greater number antibodies, thereby capture antigens achieving dual amplification signal. technique relied formation sandwich-type immunocomplexes. Upon generation hydroxyl radicals superoxide anion through catalytic decomposition H2O2 by NCs, ABEI within immunocomplexes could efficiently react with these radicals, leading to significant enhancement in signals. C-reactive protein (CRP) chosen as model analyte evaluate practicability proposed immunoassay. Notably, presented high sensitivity, selectivity, reproducibility, successfully determining CRP serum samples recoveries 96.55–106.29%. Accordingly, advantage separation-free, wash-free, reliable characteristics drastically simplify operation steps enhance efficiency, which would make advances revolution traditional

Language: Английский

Citations

1
Multi-functional nanozyme-integrated astragalus polysaccharide hydrogel for targeted phased therapy in diabetic wound healing DOI
Xiaoru Zhang, S. X. Wen, Qin Liu

et al.

Nano Today, Journal Year: 2025, Volume and Issue: 62, P. 102739 - 102739

Published: April 1, 2025

Language: Английский

Citations

1
Recent Development of Nanozymes for Combating Bacterial Drug Resistance: A Review DOI

Lingping Xie,

Haoyue Wu, Yuanfeng Li

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 10, 2024

The World Health Organization has warned that without effective action, deaths from drug-resistant bacteria can exceed 10 million annually, making it the leading cause of death. Conventional antibiotics are becoming less due to rapid bacterial drug resistance and slowed new antibiotic development, necessitating strategies. Recently, materials with catalytic/enzymatic properties, known as nanozymes, have been developed, inspired by natural enzymes essential for eradication. Unlike recent literature reviews broadly cover nanozyme design biomedical applications, this review focuses on latest advancements in nanozymes combating resistance, emphasizing their design, structural characteristics, applications combination therapy, future prospects. This approach aims promote development especially towards clinical translation.

Language: Английский

Citations

5
Beyond Drug Delivery: Metal–Organic Framework-Derived Nanosystems for Bone Regeneration under Complicated Pathological Microenvironments DOI
Yüe Zhao, Yuan Xiong,

Yanli Zhao

et al.

Accounts of Materials Research, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 22, 2024

Language: Английский

Citations

3
Protein-Based Biomaterials for Tissue Engineering and Regenerative Medicine DOI Creative Commons
Bin Yang, Na Li

IntechOpen eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

Protein-based biomaterials are increasingly recognized for their pivotal role in tissue engineering and regenerative medicine due to superior biocompatibility, biodegradability, bioresorbability. This chapter explores the development application of protein-based that enhance cell proliferation, adhesion, integration with native tissues support regeneration. The present book outlines different types proteins used as elucidates mechanisms action By utilizing advanced fabrication techniques such electrospinning, 3D bioprinting, encapsulation adsorption methods, biomimetic scaffolds replicate extracellular matrix (ECM) can be created delivery systems therapeutic stability efficacy developed. In addition, addresses critical challenges associated extensive defects, offering promising advancements fields medicine.

Language: Английский

Citations

0
Pt nanoparticles functionalized hydrogen-bonded organic frameworks: A three-in-one nanozyme for colorimetric detection of alkaline phosphatase DOI
Jiamin Huang, Hong Zhao,

Xinlian Chen

et al.

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2025, Volume and Issue: 333, P. 125894 - 125894

Published: Feb. 11, 2025

Language: Английский

Citations

0
Sensitive colorimetric sensing of dopamine and TYR based on enhanced HRP-like activity of CuNi/Fe LDHs nanozymes DOI

Fenghua Geng,

Min Huang, Xiaoli Zhang

et al.

Microchimica Acta, Journal Year: 2025, Volume and Issue: 192(3)

Published: March 1, 2025

Language: Английский

Citations

0