All-Natural Milk-Enhanced Polymerizable Deep Eutectic Solvent Elastic Ionogel Fibers toward Flexible Wearable Sensors DOI
Jun Wu,

Xinhua Liu,

Xiang‐Yun Du

et al.

ACS Applied Polymer Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

Elastic ionogel fibers have scored tremendous achievements with the rapid development of artificial intelligence and electronic techniques. However, conventional elastic materials usually suffer from poor mechanical strength, high cost, toxicity, pollution, which severely restrict their practical applications. To meet this challenge, we design a biobased fiber by using eco-friendly polymerizable deep eutectic solvents (PDESs) as substrate all-natural milk reinforcement. This milk-based PDES exhibits remarkable properties (7.52 MPa tensile stress) due to intrinsic hydrogen bonding interactions between molecular network protein, is three times much that pure fiber. Meanwhile, also shows extreme-environment resistance, can maintain most flexibility after being treated at −60 60 °C. More importantly, possesses self-healing property under humidity strain-sensing behavior, be utilized monitor human motion signals. work not only developed high-performance through low-cost green manner but promoted fundamental research industrialization flexible wearable materials.

Language: Английский

Injectable hydrogels for bioelectronics: A viable alternative to traditional hydrogels DOI
Q.S. Shu, Yuzhe Gu, Wenjie Xia

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 495, P. 153391 - 153391

Published: June 22, 2024

Language: Английский

Citations

9

Ways forward with conductive hydrogels: Classifications, properties, and applications in flexible electronic and energy gadgets DOI
Weilin Zhang, Hongjian Zhang, Hyunseung Kim

et al.

Materials Science and Engineering R Reports, Journal Year: 2025, Volume and Issue: 163, P. 100923 - 100923

Published: Jan. 8, 2025

Language: Английский

Citations

1

Injectable pH Responsive Conductive Hydrogel for Intelligent Delivery of Metformin and Exosomes to Enhance Cardiac Repair after Myocardial Ischemia‐Reperfusion Injury DOI Creative Commons

Nianlan Cheng,

Qiao Luo,

Yongqing Yang

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

Abstract Myocardial ischemia‐reperfusion injury (MIRI) is a leading cause of complications and high mortality associated with acute myocardial infarction. Injectable hydrogel emerges as promising biomaterial for repair due to their ability mimic the mechanical electrophysiological properties heart tissue. In this study, an injectable conductive developed that responds weakly acidic microenvironment ischemic injury, enabling intelligent release metformin exosomes enhance cardiac following MIRI. This multifunctional demonstrates self‐healing properties, shear‐thinning injectability, electrical conductivity, elastic modulus comparable natural myocardium, alongside excellent biocompatibility. At cellular level, system exhibits significant antioxidant, anti‐apoptotic, improvement characteristics, mitochondrial protection angiogenic effects, transcriptome sequencing revealing effective activation PI3K/AKT, VEGF, AMPK signaling pathways. vivo studies further confirm treatment reduces infarct size, fibrosis incidence arrhythmia, while improving ventricular ejection fraction facilitating restoration function after conclusion, pH‐responsive presented enables delivery exosomes, offering novel therapeutic approach enhancing treating

Language: Английский

Citations

1

Microenvironment‐Regulated Hydrogels Prepared with a Brand‐New Small Molecule Cross‐Linker for Stepwise Treatment of Myocardial Infarction DOI Open Access

Yu Wu,

Wen Zhang, Linlin Huang

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Abstract Despite the development of many injectable hydrogels intended for repair myocardial infarction (MI), their effectiveness is often compromised because they target merely one or two phases MI's pathological progression. Here, a multifunctional hydrogel delivery platform prepared with brand‐new small molecule cross‐linker stepwise treatment MI. The synthesis and reporting novel small‐molecule phenylboronic acid ((N(BA) 3 )) precise molecular structure conducted first time, it successfully utilized polyvinyl alcohol (PVA) dopamine to prepare infarct microenvironmental responsiveness anti‐oxidant. Further, considering multistage MI repair, contains both hyperoside bioactive nanoparticles (EGCG@Hyp&Arg NPs) PLGA microspheres loaded galunisertib (PLGA@Gal Ms). EGCG@Hyp&Arg NPs are rapidly released demonstrate anti‐inflammatory pro‐angiogenesis effects, while in long term, Gal from PLGA@Gal Ms inhibit fibrosis improve cardiac function. Results vitro vivo studies reveal that engineered programmed capabilities anti‐oxidation, reducing inflammation, promoting new blood vessel formation, inhibiting fibrosis, thereby significantly enhancing heart function post‐MI. Overall, this has great potential application as therapeutic strategy

Language: Английский

Citations

1

Hydrogel adhesives for tissue recovery DOI

Haohao Cui,

Jinguo Li

Advances in Colloid and Interface Science, Journal Year: 2025, Volume and Issue: unknown, P. 103496 - 103496

Published: March 1, 2025

Language: Английский

Citations

1

Adhesive and Conductive Hydrogels for the Treatment of Myocardial Infarction DOI Open Access

Jialiang Zhao,

Ying Chen, Yuanyuan Qin

et al.

Macromolecular Rapid Communications, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Abstract Myocardial infarction (MI) is a leading cause of mortality among cardiovascular diseases. Following MI, the damaged myocardium progressively being replaced by fibrous scar tissue, which exhibits poor electrical conductivity, ultimately resulting in arrhythmias and adverse cardiac remodeling. Due to their extracellular matrix‐like structure excellent biocompatibility, hydrogels are emerging as focal point tissue engineering. However, traditional lack necessary conductivity restore signal transmission infarcted regions. Imparting while also enhancing adhesive properties enables them adhere closely myocardial establish stable connections, facilitate synchronized contraction repair within area. This paper reviews strategies for constructing conductive hydrogels, focusing on application MI repair. Furthermore, challenges future directions developing discussed.

Language: Английский

Citations

0

Development of a dual-responsive injectable GelMA/F127DA hydrogel for enhanced cartilage regeneration in osteoarthritis: Harnessing MMP-triggered and mechanical stress-induced release of therapeutic agents DOI
Qi Sun,

Yuanbin Zhang,

Baisong Hu

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140823 - 140823

Published: Feb. 1, 2025

Language: Английский

Citations

0

Photocurable Reduced Graphene Oxide Containing Vitamin E-Loaded Dextran Based Cardiac Hydrogel Patches: Synthesis, Physical Characterization and In Vitro Assessment DOI

Esra Pervin Kızılcaoğlu,

Bengi Özkahraman

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106796 - 106796

Published: March 1, 2025

Language: Английский

Citations

0

Engineering functional electroconductive hydrogels for targeted therapy in myocardial infarction repair DOI

Qiang Lv,

Dandan Zhou, Yutong He

et al.

Bioactive Materials, Journal Year: 2025, Volume and Issue: 49, P. 172 - 192

Published: March 9, 2025

Language: Английский

Citations

0

Robust Neural Interfaces Enabled by Non‐Deformable Adhesive Hydrogel Patch for Stable Chronic ECoG Recording DOI Open Access
Wenlong Li, Xing Li, Ming Yang

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 12, 2025

Abstract Micro‐electrocorticography (micro‐ECoG) with superior temporal and spatial resolution plays a critical role in precise brain mapping decoding of activities. However, due to inevitable device‐brain displacement cerebrospinal fluid, the weak physical attachment micro‐ECoG devices on cortical arachnoid tissue cannot ensure stable neural interface achieve durable reliable ECoG recording over time. Herein, robust is explored using bio‐adhesive hydrogel patch for chronic recording. To overcome challenges dimensional instability hydrogels, such as swelling shrinkage, which would impede safe integration fragile surface, non‐deformable developed through rational design balanced molecular chain topology resist changes. The multifunctional demonstrates desired merits including rapid wet‐tissue adhesion (within 30 s), anti‐postoperative adhesion, excellent biocompatibility, ease surgical handling, scalability large‐scale production. Compared conventional or contractile surface can effectively inhibit fibrous capsule formation glial cell recruitment. Furthermore, long‐term recordings from integrated patches demonstrate stability high‐fidelity electrophysiological signals, making it promising advancement chronic, durable, applications.

Language: Английский

Citations

0