Elastic
ionogel
fibers
have
scored
tremendous
achievements
with
the
rapid
development
of
artificial
intelligence
and
electronic
techniques.
However,
conventional
elastic
materials
usually
suffer
from
poor
mechanical
strength,
high
cost,
toxicity,
pollution,
which
severely
restrict
their
practical
applications.
To
meet
this
challenge,
we
design
a
biobased
fiber
by
using
eco-friendly
polymerizable
deep
eutectic
solvents
(PDESs)
as
substrate
all-natural
milk
reinforcement.
This
milk-based
PDES
exhibits
remarkable
properties
(7.52
MPa
tensile
stress)
due
to
intrinsic
hydrogen
bonding
interactions
between
molecular
network
protein,
is
three
times
much
that
pure
fiber.
Meanwhile,
also
shows
extreme-environment
resistance,
can
maintain
most
flexibility
after
being
treated
at
−60
60
°C.
More
importantly,
possesses
self-healing
property
under
humidity
strain-sensing
behavior,
be
utilized
monitor
human
motion
signals.
work
not
only
developed
high-performance
through
low-cost
green
manner
but
promoted
fundamental
research
industrialization
flexible
wearable
materials.
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 18, 2025
Abstract
Myocardial
ischemia‐reperfusion
injury
(MIRI)
is
a
leading
cause
of
complications
and
high
mortality
associated
with
acute
myocardial
infarction.
Injectable
hydrogel
emerges
as
promising
biomaterial
for
repair
due
to
their
ability
mimic
the
mechanical
electrophysiological
properties
heart
tissue.
In
this
study,
an
injectable
conductive
developed
that
responds
weakly
acidic
microenvironment
ischemic
injury,
enabling
intelligent
release
metformin
exosomes
enhance
cardiac
following
MIRI.
This
multifunctional
demonstrates
self‐healing
properties,
shear‐thinning
injectability,
electrical
conductivity,
elastic
modulus
comparable
natural
myocardium,
alongside
excellent
biocompatibility.
At
cellular
level,
system
exhibits
significant
antioxidant,
anti‐apoptotic,
improvement
characteristics,
mitochondrial
protection
angiogenic
effects,
transcriptome
sequencing
revealing
effective
activation
PI3K/AKT,
VEGF,
AMPK
signaling
pathways.
vivo
studies
further
confirm
treatment
reduces
infarct
size,
fibrosis
incidence
arrhythmia,
while
improving
ventricular
ejection
fraction
facilitating
restoration
function
after
conclusion,
pH‐responsive
presented
enables
delivery
exosomes,
offering
novel
therapeutic
approach
enhancing
treating
Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 4, 2025
Abstract
Despite
the
development
of
many
injectable
hydrogels
intended
for
repair
myocardial
infarction
(MI),
their
effectiveness
is
often
compromised
because
they
target
merely
one
or
two
phases
MI's
pathological
progression.
Here,
a
multifunctional
hydrogel
delivery
platform
prepared
with
brand‐new
small
molecule
cross‐linker
stepwise
treatment
MI.
The
synthesis
and
reporting
novel
small‐molecule
phenylboronic
acid
((N(BA)
3
))
precise
molecular
structure
conducted
first
time,
it
successfully
utilized
polyvinyl
alcohol
(PVA)
dopamine
to
prepare
infarct
microenvironmental
responsiveness
anti‐oxidant.
Further,
considering
multistage
MI
repair,
contains
both
hyperoside
bioactive
nanoparticles
(EGCG@Hyp&Arg
NPs)
PLGA
microspheres
loaded
galunisertib
(PLGA@Gal
Ms).
EGCG@Hyp&Arg
NPs
are
rapidly
released
demonstrate
anti‐inflammatory
pro‐angiogenesis
effects,
while
in
long
term,
Gal
from
PLGA@Gal
Ms
inhibit
fibrosis
improve
cardiac
function.
Results
vitro
vivo
studies
reveal
that
engineered
programmed
capabilities
anti‐oxidation,
reducing
inflammation,
promoting
new
blood
vessel
formation,
inhibiting
fibrosis,
thereby
significantly
enhancing
heart
function
post‐MI.
Overall,
this
has
great
potential
application
as
therapeutic
strategy
Macromolecular Rapid Communications,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 13, 2025
Abstract
Myocardial
infarction
(MI)
is
a
leading
cause
of
mortality
among
cardiovascular
diseases.
Following
MI,
the
damaged
myocardium
progressively
being
replaced
by
fibrous
scar
tissue,
which
exhibits
poor
electrical
conductivity,
ultimately
resulting
in
arrhythmias
and
adverse
cardiac
remodeling.
Due
to
their
extracellular
matrix‐like
structure
excellent
biocompatibility,
hydrogels
are
emerging
as
focal
point
tissue
engineering.
However,
traditional
lack
necessary
conductivity
restore
signal
transmission
infarcted
regions.
Imparting
while
also
enhancing
adhesive
properties
enables
them
adhere
closely
myocardial
establish
stable
connections,
facilitate
synchronized
contraction
repair
within
area.
This
paper
reviews
strategies
for
constructing
conductive
hydrogels,
focusing
on
application
MI
repair.
Furthermore,
challenges
future
directions
developing
discussed.
Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 12, 2025
Abstract
Micro‐electrocorticography
(micro‐ECoG)
with
superior
temporal
and
spatial
resolution
plays
a
critical
role
in
precise
brain
mapping
decoding
of
activities.
However,
due
to
inevitable
device‐brain
displacement
cerebrospinal
fluid,
the
weak
physical
attachment
micro‐ECoG
devices
on
cortical
arachnoid
tissue
cannot
ensure
stable
neural
interface
achieve
durable
reliable
ECoG
recording
over
time.
Herein,
robust
is
explored
using
bio‐adhesive
hydrogel
patch
for
chronic
recording.
To
overcome
challenges
dimensional
instability
hydrogels,
such
as
swelling
shrinkage,
which
would
impede
safe
integration
fragile
surface,
non‐deformable
developed
through
rational
design
balanced
molecular
chain
topology
resist
changes.
The
multifunctional
demonstrates
desired
merits
including
rapid
wet‐tissue
adhesion
(within
30
s),
anti‐postoperative
adhesion,
excellent
biocompatibility,
ease
surgical
handling,
scalability
large‐scale
production.
Compared
conventional
or
contractile
surface
can
effectively
inhibit
fibrous
capsule
formation
glial
cell
recruitment.
Furthermore,
long‐term
recordings
from
integrated
patches
demonstrate
stability
high‐fidelity
electrophysiological
signals,
making
it
promising
advancement
chronic,
durable,
applications.
