Size-dependent dynamics and tissue-specific distribution of nano-plastics in Danio rerio: Accumulation and depuration DOI
Théogène Habumugisha,

Zixing Zhang,

Changzhou Yan

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 484, P. 136775 - 136775

Published: Dec. 4, 2024

Language: Английский

Unveiling the Heart’s Hidden Enemy: Dynamic Insights into Polystyrene Nanoplastic-Induced Cardiotoxicity Based on Cardiac Organoid-on-a-Chip DOI

Tianyi Zhang,

Sheng Yang, Yiling Ge

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(45), P. 31569 - 31585

Published: Nov. 1, 2024

Exposure to micro- and nanoplastics (MNPs) has been implicated in potential cardiotoxicity. However, vitro models based on cardiomyocyte cell lines lack crucial cardiac characteristics, while interspecies differences animal compromise the reliability of conclusions. In addition, current research predominantly focused single-time point exposures MNPs, neglecting comparative analyses injury across early late stages. Moreover, there remains a large gap understanding susceptibility MNPs under pathological conditions. To address these limitations, this study integrated organoids (COs) organ-on-a-chip (OoC) technology develop organoid-on-a-chip (COoC), which was validated for cardiotoxicity evaluation through multiple dimensions. Based COoC, we conducted dynamic observation damage caused by short- long-term exposure polystyrene (PS-NPs). Oxidative stress, inflammation, disruption calcium ion homeostasis, mitochondrial dysfunction were confirmed as mechanisms PS-NP-induced events stages, fibrosis emerged prominent feature Notably, low-dose exacerbated myocardial infarction symptoms states, despite no significant shown healthy models. conclusion, findings further deepened our cardiotoxic effects introduced promising platform assessing

Language: Английский

Citations

4
Global Distribution Characteristics and Ecological Risk Assessment of Microplastics in Aquatic Organisms Based on Meta-Analysis DOI
Yifei Li,

Wei Ling,

Chaojun Hou

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: unknown, P. 137977 - 137977

Published: March 1, 2025

Language: Английский

Citations

0
Bringing ophthalmology into the scientific world: Novel nanoparticle-based strategies for ocular drug delivery DOI
Milad Abbasi, Hossein Aghamollaei, Ahmad Vaez

et al.

The Ocular Surface, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Polystyrene microplastics induce depression-like behavior in zebrafish via neuroinflammation and circadian rhythm disruption DOI
Bang‐Hung Yang, Yu Han, Siqi Hu

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 959, P. 178085 - 178085

Published: Dec. 20, 2024

Language: Английский

Citations

3
Visible Combined Near-Infrared in Situ Imaging Revealed Dynamic Effects of Microplastic Fibers and Beads in Zebrafish DOI
Lanpeng Yang, Lin Yuan, Wen‐Xiong Wang

et al.

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: 58(37), P. 16269 - 16281

Published: Aug. 30, 2024

Microplastics (MPs) as emerging contaminants are widely present in the environment and ubiquitously ingested accumulated by aquatic organisms. MPs may be quickly eliminated after a brief retention animals (such digestive tract); thus, understanding damage caused during this process whether can recovered is important. Here, we proposed use of visible light imaging to track combined with near-infrared (NIR) reveal

Language: Английский

Citations

1
Size-dependent dynamics and tissue-specific distribution of nano-plastics in Danio rerio: Accumulation and depuration DOI
Théogène Habumugisha,

Zixing Zhang,

Changzhou Yan

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 484, P. 136775 - 136775

Published: Dec. 4, 2024

Language: Английский

Citations

1