From heterogeneity to prognosis: understanding the complexity of tertiary lymphoid structures in tumors

Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)

Published: Feb. 4, 2025

Language: Английский

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Colloidal-fibrillar composite gels demonstrate structural reinforcement, secondary fibrillar alignment, and improved vascular healing outcomes

Communications Engineering, Journal Year: 2025, Volume and Issue: 4(1)

Published: April 8, 2025

Many biological tissues contain colloids within a fibrillar structure. Here, we develop and characterize colloidal-fibrillar scaffolds through examination of the effects relative colloid fiber ratios fibrin-based model system composed nanoparticles (FBNs) natural fibrin scaffold. At lower concentrations, FBNs primarily integrate into matrix, strengthening it. high colloid-colloid interactions dominate form highly aligned secondary structure that does not strengthen matrix. intermediate both reinforcement matrix are observed. Our characterization this provides insight new avenues for wound healing biomaterial development. Using structural mechanical results, developed biomimetic surgical sealant. When applied to vascular model, FBN gel resulted in improved vessel healing. This composite can greatly improve outcomes should be other tissues.

Language: Английский

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Bio-inspired biorthogonal compartmental microparticles for tumor chemotherapy and photothermal therapy

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Aug. 20, 2024

Microcarrier is a promising drug delivery system demonstrating significant value in treating cancers. One of the main goals to devise microcarriers with ingenious structures and functions achieve better therapeutic efficacy tumors. Here, inspired by nucleus-cytoplasm structure cells material exchange reaction between them, we develop type biorthogonal compartmental microparticles (BCMs) from microfluidics that can separately load sequentially release cyclooctene-modified doxorubicin prodrug (TCO-DOX) tetrazine-modified indocyanine green (Tz-ICG) for tumor therapy. The Tz-ICG works not only as an activator TCO-DOX but also photothermal agent, allowing combination bioorthogonal chemotherapy therapy (PTT). Besides, modification DOX cyclooctene significantly decreases systemic toxicity DOX. As result, developed BCMs demonstrate efficient vitro cell eradication exhibit notable growth inhibition favorable safety. These findings illustrate formulated establish platform activation localized delivery, holding potential cancer related applications.

Language: Английский

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Biohybrid hydrogel inhibiting β-klotho/HDAC3 axis for hepatocellular carcinoma treatment

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 277, P. 134369 - 134369

Published: Aug. 3, 2024

Language: Английский

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