Configuration‐Mediated Efficient Non‐Radiative Transition for R848‐Assisted Photothermal Immunotherapy to Inhibit Tumor Growth and Metastasis by An In Situ Tumor Vaccine Strategy

Angewandte Chemie, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 3, 2024

Abstract Cancer metastasis remains a critical factor contributing to the current limitations in cancer treatment. Photothermal immunotherapy has emerged as safe and potent therapeutic approach, demonstrating capability suppress tumor growth metastasis. While researchers have extensively investigated various structural modifications enhance photothermal conversion performance, influence of molecular configuration received comparatively limited attention. In this study, we synthesized two isomers, CZTBT LVTBT, which possessed distinct configurations. characterized by flatter configuration, exhibited an extended absorption wavelength higher molar extinction coefficient. Its excited state facilitated stronger rotation for non‐radiative transitions, leading high efficiency (PCE) 36.3 %. When combined with R848, LVTBT@R848 nanoparticles (NPs)‐mediated functioned situ vaccine, promoting maturation dendritic cells (DCs), T cell infiltration, differentiation natural killer (NK) memory cells, thereby activating strong immune response. Consequently, it significantly inhibited both primary distant tumors, while also limiting lung summary, study proposed configuration‐mediated transition strategy efficient immunotherapy, advancing frontiers organic agents (OPTAs) design synthesis.

Language: Английский

Configuration‐Mediated Efficient Non‐Radiative Transition for R848‐Assisted Photothermal Immunotherapy to Inhibit Tumor Growth and Metastasis by An In Situ Tumor Vaccine Strategy

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 3, 2024

Cancer metastasis remains a critical factor contributing to the current limitations in cancer treatment. Photothermal immunotherapy has emerged as safe and potent therapeutic approach, demonstrating capability suppress tumor growth metastasis. While researchers have extensively investigated various structural modifications enhance photothermal conversion performance, influence of molecular configuration received comparatively limited attention. In this study, we synthesized two isomers, CZTBT LVTBT, which possessed distinct configurations. characterized by flatter configuration, exhibited an extended absorption wavelength higher molar extinction coefficient. Its excited state facilitated stronger rotation for non-radiative transitions, leading high efficiency (PCE) 36.3 %. When combined with R848, LVTBT@R848 nanoparticles (NPs)-mediated functioned situ vaccine, promoting maturation dendritic cells (DCs), T cell infiltration, differentiation natural killer (NK) memory cells, thereby activating strong immune response. Consequently, it significantly inhibited both primary distant tumors, while also limiting lung summary, study proposed configuration-mediated transition strategy efficient immunotherapy, advancing frontiers organic agents (OPTAs) design synthesis.

Language: Английский