Tailored Metal‐Organic Framework‐Based Nanozymes for Enhanced Enzyme‐Like Catalysis

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 19, 2024

Abstract The global crisis of bacterial infections is exacerbated by the escalating threat microbial antibiotic resistance. Nanozymes promise to provide ingenious solutions. Here, we reported a homogeneous catalytic structure Pt nanoclusters with finely tuned metal–organic framework (ZIF‐8) channel structures for treatment infected wounds. Catalytic site normalization showed that active aggregates fine‐tuned pore modifications had capacity 14.903×10 5 min −1 , which was 18.7 times higher than particles in monodisperse state ZIF‐8 (0.793×10 ). In situ tests revealed change from homocleavage heterocleavage hydrogen peroxide at interface nanozyme one key reasons improvement activity. Density‐functional theory and kinetic simulations reaction jointly determine role center substrate together. Metabolomics analysis developed nanozyme, working conjunction reactive oxygen species, could effectively block energy metabolic pathways within bacteria, leading spontaneous apoptosis rupture. This pioneering study elucidates new ideas regulation artificial enzyme activity provides perspectives development efficient substitutes.

Language: Английский

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Inverse Oxide/Alloy‐Structured Nanozymes with NIR‐Triggered Enzymatic Cascade Regulation of ROS Homeostasis for Efficient Wound Healing

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

The precise spatiotemporal control of reactive oxygen species (ROS) generation and scavenging remains pivotal for infected wound healing. However, conventional nanozymes fail to adaptively regulate ROS dynamics across inflammatory proliferative phases. A near-infrared (NIR)-activated inverse oxide/alloy-structured nanozyme (Co7Fe3/ZnO@C) is developed, featuring enzymatic cascade activities tune homeostasis through synergistic chemodynamic (CDT), photodynamic (PDT), photothermal (PTT) therapies. orchestrates a self-regulated cascade: peroxidase (POD)-like activity initially generates bactericidal hydroxyl radicals in acidic wounds, while subsequent NIR triggers hot electron transfer from Co7Fe3 ZnO, facilitating synchronized superoxide dismutase (SOD)-like, catalase (CAT)-like radical antioxidant capacity (HORAC) scavenge residual ROS. This cascaded network dynamically balances production (POD) (NIR-driven SOD/CAT/HORAC), eradicating bacteria resolving inflammation. In vitro/vivo studies have shown that the proposed method maintaining can markedly enhance rate healing by regulation environment within injured tissue facilitation rapid re-epithelialization. work provides an intelligent platform simulates function natural enzymes constructs reaction strategy balance antibacterial anti-inflammatory demands microenvironment.

Language: Английский

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Nanozyme-Based Strategies against Bone Infection

Research, Journal Year: 2025, Volume and Issue: 8

Published: Jan. 1, 2025

Nanozymes are a class of nanomaterials that exhibit catalytic functions analogous to those natural enzymes. They demonstrate considerable promise in the biomedical field, particularly treatment bone infections, due their distinctive physicochemical properties and adjustable activities. Bone infections (e.g., periprosthetic osteomyelitis) challenging treat clinically. Traditional treatments often encounter issues related drug resistance suboptimal anti-infection outcomes. The advent nanozymes has brought with it new avenue hope for infections.

Language: Английский

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An enzymatic and metal-organic framework system to prevent biofilm infections

Cell Reports Physical Science, Journal Year: 2025, Volume and Issue: unknown, P. 102468 - 102468

Published: March 1, 2025

Language: Английский

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An “all-in-one” therapeutic platform for programmed antibiosis, immunoregulation and neuroangiogenesis to accelerate diabetic wound healing

Biomaterials, Journal Year: 2025, Volume and Issue: unknown, P. 123293 - 123293

Published: March 1, 2025

Language: Английский

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Multi-modal Microcarriers Reprogram Mitochondrial Metabolism and Activate Efferocytosis in Macrophages for Osteoporotic Bone Repair

Biomaterials, Journal Year: 2025, Volume and Issue: 322, P. 123384 - 123384

Published: May 2, 2025

Language: Английский

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Construction of natural hydrogels consisting of oxidized dextran, quaternized chitosan and cuttlefish ink nanoparticles for treating diabetic oral ulcers

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 283, P. 137737 - 137737

Published: Nov. 17, 2024

Language: Английский

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Photothermal Nano‐Immunotherapy Against Methicillin‐Resistant Staphylococcus aureus (MRSA) Biofilm Infections

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 19, 2024

Methicillin-resistant Staphylococcus aureus (MRSA) biofilm infections are a prevalent type of biofilm-associated infection with poor prognosis and antibiotic resistance. The senescence immune cells in the microenvironment contributes to formation. In this study, Ti₃C₂ MXene-PVA nanosheets loaded metformin (Met@TiC) developed for treatment MRSA infections. Nanosheets utilize near-infrared light induce photothermal effects provide direct bactericidal activity against structures. Met, which is known its anti-inflammatory anti-senescence properties, modulates responses by revitalizing function senescent macrophages within microenvironment, thereby enhancing their phagocytic biofilm-eradicating capabilities. efficacy nanoplatform both vitro an mouse model, demonstrating potential as nanoimmunotherapy combating validated. summary, Met@TiC offers significant alternative clinical solutions

Language: Английский

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