Engineered Extracellular Vesicles as a New Class of Nanomedicine DOI Creative Commons

Xiaowei Wen,

Zhengping Hao, Haofan Yin

et al.

Chem & Bio Engineering, Journal Year: 2024, Volume and Issue: 2(1), P. 3 - 22

Published: Oct. 28, 2024

Extracellular vesicles (EVs) are secreted from biological cells and contain many molecules with diagnostic values or therapeutic functions. There has been great interest in academic industrial communities to utilize EVs as tools for diagnosis therapeutics. In addition, can also serve delivery vehicles molecules. An indicator of the enormous is large number review articles published on EVs, focus ranging their biology applications. emerging trend EV research produce "engineered EVs", which essentially enhanced version EVs. engineering be conducted by cell culture condition control, genetic engineering, chemical engineering. Given nanometer-scale sizes potentials, engineered an class nanomedicines. So far, overwhelming majority preclinical studies; there only a very small reported clinical trials. This Review focuses more specific being applications The various approaches producing diseases reviewed. Furthermore, vivo imaging mechanistic understandings, translation aspects discussed. discussion primarily studies while briefly mentioning With continued interdisciplinary efforts biologists, pharmacists, physicians, bioengineers, engineers, could become powerful solution major such neurological, immunological, cardiovascular diseases.

Language: Английский

Autophagy activation within inflammatory microenvironment improved the therapeutic effect of MSC-Derived extracellular Vesicle in SLE DOI Creative Commons

Shuzhen Liao,

Fengbiao Guo,

Zengzhi Xiao

et al.

Journal of Advanced Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Mesenchymal Stromal Cell-Based Therapy: A Promising Approach for Autoimmune Diseases DOI
Liming Li, Yong He,

Junpeng Zhao

et al.

Clinical Reviews in Allergy & Immunology, Journal Year: 2025, Volume and Issue: 68(1)

Published: Feb. 21, 2025

Language: Английский

Citations

0
Recent advances in the role of mesenchymal stem cells as modulators in autoinflammatory diseases DOI Creative Commons
Baiyu Chen, Zhilei Chen, Mei He

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 20, 2024

Mesenchymal stem cells (MSCs), recognized for their self-renewal and multi-lineage differentiation capabilities, have garnered considerable wide attention since discovery in bone marrow. Recent studies underscored the potential of MSCs immune regulation, particularly context autoimmune diseases, which arise from system imbalances necessitate long-term treatment. Traditional immunosuppressive drugs, while effective, can lead to drug tolerance adverse effects, including a heightened risk infections malignancies. Consequently, adjuvant therapy incorporating has emerged as promising new treatment strategy, leveraging immunomodulatory properties. This paper reviews mechanisms application highlighting regulate responses reduce inflammation. The are primarily mediated through direct cell contact paracrine activity with cells. review lays groundwork broader clinical future underscores significant scientific value prospects. Further research is expected enhance efficacy safety MSCs-based treatments diseases.

Language: Английский

Citations

3
CAR T-cell therapy for systemic lupus erythematosus: current status and future perspectives DOI Creative Commons
Jincai Zhou,

Bixia Lei,

Feifei Shi

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 19, 2024

Systemic lupus erythematosus (SLE) and nephritis (LN) are debilitating autoimmune disorders characterized by pathological autoantibodies production immune dysfunction, causing chronic inflammation multi-organ damage. Despite current treatments with antimalarial drugs, glucocorticoids, immunosuppressants, monoclonal antibodies, a definitive cure remains elusive, highlighting an urgent need for novel therapeutic strategies. Recent studies indicate that chimeric antigen receptor T-cell (CAR-T) therapy has shown promising results in treating B-cell malignancies may offer significant breakthrough non-malignant conditions like SLE. In this paper, we aim to provide in-depth analysis of the advancements CAR-T SLE, focusing on its potential revolutionize treatment complex disease. We explore fundamental mechanisms cell action, rationale application immunological underpinnings also summarize clinical data safety efficacy anti-CD19 anti-B maturation (BCMA) cells targeting B-cells discuss implications these findings improve outcomes severe or refractory SLE cases. The integration into paradigm presents new horizon autoimmunity research practice. This review underscores continued exploration optimization strategies address unmet needs patients.

Language: Английский

Citations

2
Engineered Extracellular Vesicles as a New Class of Nanomedicine DOI Creative Commons

Xiaowei Wen,

Zhengping Hao, Haofan Yin

et al.

Chem & Bio Engineering, Journal Year: 2024, Volume and Issue: 2(1), P. 3 - 22

Published: Oct. 28, 2024

Extracellular vesicles (EVs) are secreted from biological cells and contain many molecules with diagnostic values or therapeutic functions. There has been great interest in academic industrial communities to utilize EVs as tools for diagnosis therapeutics. In addition, can also serve delivery vehicles molecules. An indicator of the enormous is large number review articles published on EVs, focus ranging their biology applications. emerging trend EV research produce "engineered EVs", which essentially enhanced version EVs. engineering be conducted by cell culture condition control, genetic engineering, chemical engineering. Given nanometer-scale sizes potentials, engineered an class nanomedicines. So far, overwhelming majority preclinical studies; there only a very small reported clinical trials. This Review focuses more specific being applications The various approaches producing diseases reviewed. Furthermore, vivo imaging mechanistic understandings, translation aspects discussed. discussion primarily studies while briefly mentioning With continued interdisciplinary efforts biologists, pharmacists, physicians, bioengineers, engineers, could become powerful solution major such neurological, immunological, cardiovascular diseases.

Language: Английский

Citations

0