ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 15, 2025
Surface-enhanced
Raman
scattering
has
been
widely
used
for
molecular/material
characterization
and
chemical
biological
sensing
imaging
applications.
In
particular,
plasmonic
nanogap-enhanced
(NERS)
is
based
on
the
highly
localized
electric
field
formed
within
nanogap
between
closely
spaced
metallic
surfaces
to
more
strongly
amplify
signals
than
cases
with
molecules
metal
surfaces.
Nanoparticle-based
NERS
offers
extraordinarily
strong
a
plethora
of
opportunities
in
sensing,
many
different
types
biomedical
Despite
its
potential,
several
challenges
still
remain
be
useful
real-world
This
Perspective
introduces
various
configurations
nanoparticles,
discusses
key
advances
critical
while
addressing
possible
misunderstandings
this
field,
provides
future
directions
generate
stronger,
uniform,
stable
over
large
number
structures
practical
Analytical Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 14, 2025
Surface-enhanced
Raman
spectroscopy
(SERS)
has
emerged
as
a
crucial
analytical
tool
in
the
field
of
oncology,
particularly
presenting
significant
challenges
for
diagnosis
and
treatment
head
neck
cancer.
This
Review
provides
an
overview
current
status
prospects
SERS
applications,
highlighting
their
profound
impact
on
molecular
biology-level
diagnosis,
tissue-level
identification,
HNC
therapeutic
monitoring,
integration
with
emerging
technologies.
The
application
single-molecule
assays
such
epidermal
growth
factor
receptors
PD-1/PD-L1,
gene
expression
analysis,
tumor
microenvironment
characterization
is
also
explored.
showcases
innovative
applications
liquid
biopsies
high-throughput
lateral
flow
analysis
ctDNA
quantification
salivary
diagnostics,
which
can
offer
rapid
highly
sensitive
suitable
immediate
detection.
At
tissue
level,
enables
cancer
cell
visualization
intraoperative
margin
enhancing
surgical
precision
decision-making.
role
radiotherapy,
chemotherapy,
targeted
therapy
examined
along
its
use
real-time
pharmacokinetic
studies
to
monitor
response.
Furthermore,
this
delves
into
synergistic
relationship
between
artificial
intelligence,
encompassing
machine
learning
deep
algorithms,
marking
dawn
new
era
oncology.
genomics,
metabolomics,
transcriptomics,
proteomics,
single-cell
omics
at
multiomics
level
will
revolutionize
our
comprehension
management
HNC.
offers
transformative
impacts
examines
future
directions
well
dynamic
research
field.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(43), P. 29337 - 29379
Published: Oct. 14, 2024
Catalysis
stands
as
an
indispensable
cornerstone
of
modern
society,
underpinning
the
production
over
80%
manufactured
goods
and
driving
90%
industrial
chemical
processes.
As
demand
for
more
efficient
sustainable
processes
grows,
better
catalysts
are
needed.
Understanding
working
principles
is
key,
last
50
years,
surface-enhanced
Raman
Spectroscopy
(SERS)
has
become
essential.
Discovered
in
1974,
SERS
evolved
into
a
mature
powerful
analytical
tool,
transforming
way
which
we
detect
molecules
across
disciplines.
In
catalysis,
enabled
insights
dynamic
surface
phenomena,
facilitating
monitoring
catalyst
structure,
adsorbate
interactions,
reaction
kinetics
at
very
high
spatial
temporal
resolutions.
This
review
explores
achievements
well
future
potential
field
catalysis
energy
conversion,
thereby
highlighting
its
role
advancing
these
critical
areas
research.
Analytical Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 14, 2025
Detecting
and
quantifying
mycotoxins
using
LFIA
are
challenging
due
to
the
need
for
high
sensitivity
accuracy.
To
address
this,
a
dual-mode
colorimetric-SERS
was
developed
detecting
deoxynivalenol
(DON).
Rhodium
nanocores
provided
strong
plasmonic
properties
as
SERS
substrate,
while
silver
nanoparticles
created
electromagnetic
"hotspots"
enhance
signal
sensitivity.
Finite
element
modeling
optimized
field
intensity,
Prussian
blue
generated
distinct
at
2156
cm-1,
effectively
reducing
background
interference.
This
achieved
detection
limit
of
4.21
pg/mL,
37
times
lower
than
that
colloidal
gold-based
(0.156
ng/mL).
Machine
learning
algorithms,
including
ANN
KNN,
enabled
precise
classification
quantification
contamination,
achieving
98.8%
accuracy
an
MSE
0.57.
These
results
underscore
platform's
potential
analyzing
harmful
substances
in
complex
matrices
demonstrate
important
role
machine
learning-enhanced
nanosensors
advancing
technologies.
Advanced Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 26, 2025
Nanoporous
metallic
microarchitectures
with
noncontaminated
surfaces
hold
significant
promise
in
catalytic
and
sensing
fields.
Fabrication
of
nanoporous
metal
microparticles
without
using
any
organic
ligands
remains
a
challenge.
Here,
green
synthesis
strategy
is
presented
inspired
by
dealloying
mechanisms.
Ag7O8NO3
are
first
electrodeposited.
Subsequent
chemical
reduction
process
selectively
removes
nitrogen
oxygen
species
from
the
while
preserving
original
morphology,
giving
rise
to
formation
Ag
agents
under
room
temperature
within
several
minutes.
Based
on
ion
diffusion
limited
growth
mechanism,
quantitative
correlation
established
between
opening
size
nanopores
concentration
reductive
agents,
allowing
rationally
prepare
ranging
<
20
nm
>
110
nm.
The
ultraclean
surface
guarantees
clean
surface-enhanced
Raman
spectroscopy
(SERS)
background.
Reliable
sensitive
SERS
detection
proteins
unfolding
protein
structure
further
demonstrated
expose
otherwise
concealed
parts
microparticles.
A
simple
but
powerful
approach
developed
design
promising
applications
those
fields
requiring
surfaces,
such
as
Foods,
Journal Year:
2025,
Volume and Issue:
14(7), P. 1115 - 1115
Published: March 24, 2025
Food
safety
is
directly
related
to
human
health
and
has
attracted
intense
attention
all
over
the
world.
Surface-enhanced
Raman
scattering
(SERS),
as
a
rapid
selective
technique,
been
widely
applied
in
monitoring
food
safety.
SERS
substrates,
an
essential
factor
for
sensing
design,
greatly
influence
analytical
performance.
Currently,
nanostructure-based
substrates
have
garnered
significant
interest
due
their
excellent
merits
improving
sensitivity,
specificity,
stability,
holding
great
potential
accurate
of
contaminants
complex
matrices.
This
review
summarizes
fundamentals
spectroscopy
used
nanostructures
designing
platform,
including
precious
metal
nanoparticles,
metal-organic
frameworks,
polymers,
semiconductors.
Moreover,
it
introduces
mechanisms
applications
enhancing
signals
hazardous
substances,
such
foodborne
bacteria,
pesticide
veterinary
drug
residues,
additives,
illegal
adulterants,
packaging
material
contamination.
Finally,
with
continuous
progress
nanostructure
technology
improvement
technology,
its
application
prospect
testing
will
be
broader.
Nano Letters,
Journal Year:
2024,
Volume and Issue:
24(42), P. 13447 - 13454
Published: Oct. 11, 2024
Uric
acid
is
typically
measured
through
blood
tests,
which
can
be
inconvenient
and
uncomfortable
for
patients.
Herein,
we
propose
a
wearable
surface-enhanced
Raman
scattering
(SERS)
chip,
incorporating
hydrogel
membrane
with
integrated
plasmonic
trimers,
noninvasive
monitoring
of
uric
in
sweat.
The
trimers
feature
sub
5
nm
nanogaps,
generating
strong
electromagnetic
fields
to
boost
the
signal
surrounding
molecules.
Simultaneously,
pumps
sweat
these
gaps,
efficiently
capturing
biomarkers
SERS
detection.
chip
achieve
saturation
adsorption
within
min,
eliminating
variations
individual
production
rates.
Dynamic
tracking
lactic
levels
during
anaerobic
exercise
reveals
temporary
suppression
metabolism,
likely
due
metabolic
competition
acid.
Furthermore,
long-term
correlates
well
test
results,
confirming
that
regular
helps
reduce
serum
supporting
its
potential
managing
hyperuricemia.
