Enhancing Root Canal Therapy with NIR‐II Semiconducting Polymer AIEgen and Low‐Concentration Sodium Hypochlorite Synergy DOI Open Access

Yuanzhu Zhou,

Dan Li, Xin Yue

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(30)

Published: Aug. 22, 2024

Despite significant efforts to eliminate bacterial biofilm within root canals, achieving effective disinfection remains challenging due the complex anatomy and limitations of disinfectants. In this study, a second near-infrared (NIR-II) semiconducting polymer with aggregation-induced emission (AIE) properties, named PIDT-TBT, is deliberately designed synthesized. This proposes an AIE luminogen-based sterilization strategy in synergy low concentration sodium hypochlorite (NaClO). Water-dispersible PIDT-TBT nanoparticles (NPs) are prepared, demonstrating good biocompatibility, as well photothermal photodynamic properties. Subsequent antibacterial tests show that NPs exhibit excellent bactericidal effects against three strains: Staphylococcus aureus, Streptococcus mutans, Enterococcus faecalis, upon 808 nm laser irradiation. NaClO (0.5%) solution, significantly improves outcome canal treatment under irradiation human extracted tooth infection model. Additionally, it found combine solution could safely dissolve dentin debris further increase efficiency preparation by altering elemental composition inner wall.

Language: Английский

Odontogenic exosomes simulating the developmental microenvironment promote complete regeneration of pulp-dentin complex in vivo DOI Creative Commons
Yifan Wang, Jing Mao, Yujie Wang

et al.

Journal of Advanced Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Establishing an optimized regenerative microenvironment for pulp-dentin complex engineering has become increasingly critical. Recently, exosomes have emerged as favorable biomimetic nanotherapeutic tools to simulate the developmental and facilitate tissue regeneration. This study aimed elucidate multifaceted roles of from human dental pulp stem cells (DPSCs) that initiated odontogenic differentiation while sustaining mesenchymal cell (MSC) characteristics in odontogenesis, angiogenesis, neurogenesis during Differential centrifugation was performed isolate normal DPSCs (DPSC-Exos) initially triggered (DPSC-Od-Exos). The impact these on biological behavior umbilical vein endothelial (HUVECs) examined vitro through CCK-8 assay Transwell migration assay, well assays dedicated assessing odontogenic, angiogenic, neurogenic capabilities. In vivo, Matrigel plugs tooth root fragments incorporating either DPSC-Exos or DPSC-Od-Exos were subcutaneously transplanted into mouse models. Subsequent histological, immunohistochemical, immunofluorescent analyses conducted determine outcomes. revealed no remarkable difference their characteristics. indicated significantly facilitated proliferation, migration, multilineage compared with DPSC-Exos. Furthermore, elicited a more pronounced effect tubular structure formation HUVECs. Consistently, plug confirmed exhibited superior performance promoting stimulating angiogenesis Notably, contributed complete regeneration fragments, characterized by enriched neurovascular structures continuous layer odontoblast-like cells, which extended cytoplasmic projections newly formed dentinal tubules. By simulating microenvironment, multifunctional demonstrated promising potential reconstructing dentin-like tissue, vascular networks, neural architectures, thereby enhancing our understanding therapeutic implications endodontic treatment.

Language: Английский

Citations

0
Hydrogels in Oral Disease Management: A Review of Innovations in Drug Delivery and Tissue Regeneration DOI Creative Commons

Dong-Wen Li,

Man Dapeng,

Yu Jiazhi

et al.

Medical Science Monitor, Journal Year: 2025, Volume and Issue: 31

Published: Jan. 10, 2025

The oral cavity is an open and complicated structure with a variety of factors affecting topical medications. physical chemical surroundings the can influence action free drugs. Thus, drug delivery system serve as support or carrier. Hydrogels are prospective tissue engineering biomaterials that demonstrate immense potential for regeneration delivery. crosslinked polymer chains 3-dimensional network take up larger volumes liquid have soft, porous closely resembles living tissue. protect active from systemic elimination, increase bioavailability absorption into cells, release modify therapeutic immediately after dosing. In this review, we introduce classification hydrogels, application hydrogels in diseases (periodontal disease, endodontics, mucosal alveolar surgery, cancer, maxillofacial bone defects, implantation), summarize synthesis methods applications discuss possible directions future development which will provide new idea formulation production more advantageous efficient system.

Language: Английский

Citations

0
Yellow light and ultrasound Dual-responsive strontium-doped zinc oxide composites for dental caries prevention and remineralization DOI
Yang Mu, Yanmei Wang, Lei Huang

et al.

Bioactive Materials, Journal Year: 2025, Volume and Issue: 47, P. 403 - 416

Published: Feb. 12, 2025

Language: Английский

Citations

0
Hydrogel design and applications for periodontitis therapy: A review DOI
Qingqing Pan, Zhihui Zong, Haibo Li

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 137893 - 137893

Published: Nov. 1, 2024

Language: Английский

Citations

3
Enhancing Root Canal Therapy with NIR‐II Semiconducting Polymer AIEgen and Low‐Concentration Sodium Hypochlorite Synergy DOI Open Access

Yuanzhu Zhou,

Dan Li, Xin Yue

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(30)

Published: Aug. 22, 2024

Despite significant efforts to eliminate bacterial biofilm within root canals, achieving effective disinfection remains challenging due the complex anatomy and limitations of disinfectants. In this study, a second near-infrared (NIR-II) semiconducting polymer with aggregation-induced emission (AIE) properties, named PIDT-TBT, is deliberately designed synthesized. This proposes an AIE luminogen-based sterilization strategy in synergy low concentration sodium hypochlorite (NaClO). Water-dispersible PIDT-TBT nanoparticles (NPs) are prepared, demonstrating good biocompatibility, as well photothermal photodynamic properties. Subsequent antibacterial tests show that NPs exhibit excellent bactericidal effects against three strains: Staphylococcus aureus, Streptococcus mutans, Enterococcus faecalis, upon 808 nm laser irradiation. NaClO (0.5%) solution, significantly improves outcome canal treatment under irradiation human extracted tooth infection model. Additionally, it found combine solution could safely dissolve dentin debris further increase efficiency preparation by altering elemental composition inner wall.

Language: Английский

Citations

2