Study on function mechanism of fluorescence tracing method at bitumen-aggregate interface

Construction and Building Materials, Journal Year: 2025, Volume and Issue: 465, P. 140177 - 140177

Published: Jan. 30, 2025

Language: Английский

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Synergistic strategies for glioblastoma treatment: CRISPR-based multigene editing combined with immune checkpoint blockade

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 7, 2025

Language: Английский

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A multifunctional ROS cascade nanoplatform enables common prosperity of O2 and H2O2 for magnetic targeting and fluorescence imaging-guided photodynamic/chemodynamic therapy

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: 506, P. 160178 - 160178

Published: Jan. 1, 2025

Language: Английский

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Tandem Targeting and Dual Aggregation of an AIEgen for Enhanced Near-Infrared Fluorescence Imaging of Tumors

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(37), P. 25462 - 25466

Published: Sept. 6, 2024

Near-infrared (NIR) aggregation-induced emission luminogens (AIEgens) are excellent probes for tumor imaging, but there still is space to improve their imaging specificity and sensitivity. In this work, a strategy of tandem targeting dual aggregation an AIEgen proposed achieve these two purposes. An AIEgen, β-tBu-Ala-Cys(StBu)-Lys(Biotin)-Pra(QMT)-CBT (

Language: Английский

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Frontiers in Fluorescence imaging: Tools for the In-Situ Sensing of Disease Biomarkers

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 3, 2024

A comprehensive overview of recent advancements in fluorescence imaging techniques for situ sensing various biomarkers, emphasizing the transformative potential artificial intelligence shaping future bioimaging.

Language: Английский

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APE1-Activated and NIR-II Photothermal-Enhanced Chemodynamic Therapy Guided by Amplified Fluorescence Imaging

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

The development of intelligent nanotheranostic technology that integrates diagnostic and therapeutic functions holds great promise for personalized nanomedicine. However, most the agents exhibit "always-on" properties do not involve an amplification step, which may largely limit imaging contrast restrict efficacy. Herein, we construct a novel platform (Hemin/DHPs/PDA@CuS nanocomposite) by assembling DNA hairpin probes (DHPs) hemin on surface PDA@CuS nanosheets enables amplified fluorescence activatable chemodynamic therapy (CDT) tumors. cancer-relevant APE1 triggers nucleic acid with DHPs to generate signals discriminating cancer cells from normal cells. Meanwhile, excessive G-quadruplex/hemin-based DNAzyme are also activated, they function as Fenton-like catalysts catalyze production highly toxic hydroxyl radicals (•OH) CDT. Moreover, owing excellent photothermal conversion efficiency in near-infrared-II (NIR-II) window, only improves catalytic performance CDT but furnishes PTT. A remarkable antitumor effect is demonstrated both vitro vivo. Therefore, Hemin/DHPs/PDA@CuS nanocomposite expected provide promising avenue precise imaging-guided therapy.

Language: Английский

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Harnessing Aggregation‐Induced Emission‐Based Detection Toolbox for Diagnostics of Urogenital Tumors

Aggregate, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 13, 2025

ABSTRACT Urogenital system tumors include prostate cancer, bladder ovarian and other very common solid tumor diseases with high morbidity mortality. The unique physiological anatomical features of the urogenital render it particularly amenable to application tissue imaging techniques for diagnostic purposes. advancement aggregation‐induced emission (AIE) materials has addressed limitations associated conventional fluorescent that are prone aggregation‐caused quenching. This facilitated development innovative AIE characterized by enhanced photostability, an increased signal‐to‐noise ratio, improved quality. article reviews research progress biosensors in diagnosis tumors. It mainly involves biomarker vitro fluorescence such as uterine which based on biosensors. In addition, a comprehensive description biosensors’ synthesis strategies is provided. includes detailed elucidation platforms intracellular mechanisms basic principles AIE, accompanied presentation quantitative analysis cell results. limitations, challenges suggestions field summarized, prospect prospected. tumors, also provides catalyst exploring characteristics its wide disease diagnosis.

Language: Английский

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Photosensitizing Quantum Dot Killers Encoded by Bivalent DNA for Sequential Cell Penetration, Intracellular Bacterial Imaging, and Targeted Elimination

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

The precise identification and efficient in situ eradication of intracellular bacteria can not only prevent the from persisting spreading within host but also accelerate healing infected wounds decrease caused complications. In this study, we designed a multifunctional quantum dot (QD) killer equipped with aggregation-induced emission (AIE) photosensitizers heterobivalent DNA sequences capability to specifically target, fluorescently image, efficiently eliminate bacteria. These QD killers undergo cell penetration following lipopolysaccharide receptor-mediated endocytosis then translocate cytosol for bacterial recognition labeling. Additionally, by leveraging robust photodynamic activity sensitizing killers, complete was realized reducing viability macrophages. cytocompatibility ensures safe treatment without harming normal cells. Notably, bacterial-infected vivo showed accelerated rates successful elimination administration. This work highlights potential eradicating hidden immune cells, providing promising strategy addressing infection-relevant diseases.

Language: Английский

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A Universal Single‐Activated‐Dual‐Release Vehicle: Enabling Synergistic Antitumor Therapy

Small, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Abstract Activatable combined therapeutic strategy exhibits significant potential for the management of malignant tumors. Ensuring timely and spatially effective release different agents is a great challenge maximizing efficacy combination therapy. Herein, based on 1,4‐and 1,6‐elimination behaviors, study proposes novel universal single‐activated‐dual‐release platform that can be triggered by various stimulants interest. As proof‐of‐concept, develops an example synergistic therapy called CyI‐Cbl‐NTR , which selectively activated nitroreductase (NTR) to photosensitizer ( CyI‐OH ) DNA alkylating agent chlorambucil (Cbl), thereby enabling chemo‐ photodynamic Both in vitro vivo experiments fully demonstrate remarkable effect Cyl‐Cbl‐NTR feasibility this strategy. This work provides promising future development activatable

Language: Английский

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Applications of Aggregation-Induced Emission Materials in Immunology: From Diagnostics to Immunotherapy

Chemical & Biomedical Imaging, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Aggregation-induced emission (AIE) materials, due to their unique ability significantly enhance optical in aggregated states, have demonstrated vast potential immunology, particularly early disease diagnosis and immunotherapy. AIE materials can serve as highly efficient fluorescent probes for biomarker detection, providing critical insights diagnosis. Additionally, they act cancer vaccines, enhancing the effectiveness of immunotherapy through photodynamic therapy, photothermal or activation immune cells. This review highlights applications focusing on recent advancements diagnostics while also discussing challenges face directions future development.

Language: Английский

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