Temperature-Triggered Reversible Adhesion Hydrogel with Responsive Drug Release, Mild Photothermal Therapy, and Biofilm Clearance for Skin Infection Healing DOI
Ying Song, Jie Zhu,

Yu-Jie Lv

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

Bacterial infection gives rise to a hypoxic, H2O2-abundant, and acidic local microenvironment at the site of inflammation, which prevents healing skin tissues. In this work, gelatin oxidized carboxymethyl cellulose were developed as framework hydrogels. Tannic acid 3-formylphenylboronic served small-molecule anchors. Through introduction multiple dynamic cross-linkings, hydrogel was endowed with various functions. These functions encompassed mechanical compatibility skin, reversible adhesion characteristics, rapid self-healing capabilities. addition, nanoflower-like MnO2 microparticles loaded berberine hydrochloride embedded. has ability not only kill bacteria through photothermal effect (PTT) but also catalyze decomposition H2O2 release oxygen, effectively improving inflammatory microenvironment. Remarkably, based on drug/PTT synergistic strategy, exhibited significant antibacterial activity biofilm removal under mild conditions (<50 °C), avoiding thermal damage healthy Consequently, hydrogels demonstrate favorable biocompatibility, cell proliferation, migration, angiogenesis, collagen deposition, tissue regeneration. Therefore, multifunctional antimicrobial is expected be skin-friendly medical dressing enormous potential in treatment soft infections.

Language: Английский

Cariogenic Microbiota and Emerging Antibacterial Materials to Combat Dental Caries: A Literature Review DOI Creative Commons
Jingwei Cao, Qizhao Ma, Jia Shi

et al.

Pathogens, Journal Year: 2025, Volume and Issue: 14(2), P. 111 - 111

Published: Jan. 23, 2025

Dental caries is the most common oral disease in world and a chronic infectious disease. The cariogenic microbiome plays an important role process of caries. ecological imbalance microbiota leads to low pH, which causes Therefore, antibacterial materials have always been hot topic. Traditional such as cationic agents, metal ion some natural extract agents good effects. However, they can cause bacterial resistance poor biological safety when used for long-term purposes. Intelligent materials, pH-responsive nanozymes, photoresponsive piezoelectric living are emerging nano-strategies that respond microenvironment or other specific stimuli exert Compared with traditional these less prone resistanceand safety. This review summarizes characteristics materials. These accurately act on microenvironment, showing intelligent effects providing new ideas management.

Language: Английский

Citations

1
Saliva-acquired pellicle inspired multifunctional gargle with wet adhesion, photodynamic antimicrobial, and In situ remineralization properties for dental caries prevention DOI
Jiayi Shi,

Xuekai Qi,

Ying Ran

et al.

Bioactive Materials, Journal Year: 2025, Volume and Issue: 47, P. 212 - 228

Published: Jan. 23, 2025

Language: Английский

Citations

0
Temperature-Triggered Reversible Adhesion Hydrogel with Responsive Drug Release, Mild Photothermal Therapy, and Biofilm Clearance for Skin Infection Healing DOI
Ying Song, Jie Zhu,

Yu-Jie Lv

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

Bacterial infection gives rise to a hypoxic, H2O2-abundant, and acidic local microenvironment at the site of inflammation, which prevents healing skin tissues. In this work, gelatin oxidized carboxymethyl cellulose were developed as framework hydrogels. Tannic acid 3-formylphenylboronic served small-molecule anchors. Through introduction multiple dynamic cross-linkings, hydrogel was endowed with various functions. These functions encompassed mechanical compatibility skin, reversible adhesion characteristics, rapid self-healing capabilities. addition, nanoflower-like MnO2 microparticles loaded berberine hydrochloride embedded. has ability not only kill bacteria through photothermal effect (PTT) but also catalyze decomposition H2O2 release oxygen, effectively improving inflammatory microenvironment. Remarkably, based on drug/PTT synergistic strategy, exhibited significant antibacterial activity biofilm removal under mild conditions (<50 °C), avoiding thermal damage healthy Consequently, hydrogels demonstrate favorable biocompatibility, cell proliferation, migration, angiogenesis, collagen deposition, tissue regeneration. Therefore, multifunctional antimicrobial is expected be skin-friendly medical dressing enormous potential in treatment soft infections.

Language: Английский

Citations

0