Dynamic Pathophysiological Insight into the Brain by NIR‐II Imaging

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

Cerebral collateral circulation and blood-brain barrier (BBB) are critically required to maintain the normal brain functions, a fact stressing need for accurate in vivo diagnostic tools that can afford valuable pathophysiological insight into functioning of neurovascular unit space time. Currently, understanding perfusion BBB evolution under both physiological pathological conditions remains sparse, largely owing limitations methods recording diminutive route cerebral blood flow. Here, it is reported highly crystalline semiconducting organic nanoprobes (named 4T-BSA) composed small-molecule dye bovine serum albumin showed vast potential live-brain vascular imaging second near-infrared window (NIR-II, 1000-1700 nm). The 4T-BSA had superior penetration depth intact mouse with high signal-to-background ratio (SBR) 6.0 down sub-50-µm spatial resolution vasculature three typical models neurological pathophysiology. By visualizing leakage, identified activities associated arterial/venous flow network disruption. It anticipated NIR-II disruption will bring broad opportunities address major medical challenges across timely, protective, restorative interventions diseases.

Language: Английский

Achieving enhancing endosome escape of Tat47-57-derived stapled peptides through decafluorobiphenyl bridge

Chinese Chemical Letters, Journal Year: 2025, Volume and Issue: unknown, P. 111278 - 111278

Published: May 1, 2025

Language: Английский