Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 249, P. 114489 - 114489
Published: Dec. 30, 2024
Language: Английский
Chinese Chemical Letters, Journal Year: 2025, Volume and Issue: unknown, P. 110834 - 110834
Published: Jan. 1, 2025
Language: Английский
Citations
0
ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 24, 2025
Thrombosis, a common underlying mechanism of myocardial infarction, ischemic stroke, and venous thromboembolism, is the leading cause death in patients. Owing to their lack targeting ability, short half-life, low utilization rate, high risk bleeding side effects, current first-line thrombolytic drugs are unable meet requirements for effective treatment thrombi. Photothermal therapy (PTT) represents promising modality due its precise spatiotemporal selectivity minimal invasiveness. However, efficacy PTT constrained by limited penetration depth conventional wavelengths, energy conversion efficiency, suboptimal performance photothermal agents. Recent advancements have demonstrated that near-infrared (NIR)-mediated nanomaterials exhibit significant advantages treating thrombotic diseases. These NIR-mediated can rapidly convert light into heat via Landau damping effect, achieving deeper tissue without inducing damage, thereby enhancing effectiveness thrombolysis. Moreover, modifiable nature these facilitates targeted aggregation at site thrombosis, enabling specific therapy. In this review, we systematically summarize recent advances with potential therapeutic applications thrombus treatment. Specifically, focus on composite incorporate multiple components construction nanocarriers. We highlight modification technologies utilize ligands enhanced application strategies biomimetic antithrombotic Additionally, discuss combined approaches such as light-triggered nitric oxide release, drug loading, photodynamic integration. methods help mitigate secondary microvascular embolization, which crucial comprehensive management. Collectively, offer novel insights
Language: Английский
Citations
0
Advanced Science, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 25, 2025
Abstract Organic radicals are considered prospective materials for near‐infrared (NIR) photothermal applications, however, sustainability remains the major obstacle of recently reported ionic radical agents. This work achieved robust on a series neutral π‐radicals through rational design donor (D)–acceptor (A). With efficient doublet internal conversion, 10H‐spiro(acridine‐9,9′‐fluorene) (SFA)‐BTM presented strong NIR absorption extended to 1000 nm and non‐radiative relaxation. SFA‐BTM nanoparticles (NPs) realized comparable NIR‐I conversion efficiency (PCE) photoacoustic sensitivity. Also, π‐radical NPs displayed NIR‐II emission high‐resolution whole‐body angiography first time by bioimaging. Ultimately, capabilities confirmed in an orthotopic bone tumor model effective ablation cancer cells vitro inhibition deterioration vivo. research offers new horizon conception development sustainable organic imaging theranostics applications.
Language: Английский
Citations
0
Bioconjugate Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Fluorescence imaging technology is playing increasing roles in modern personalized and precision medicine. Thanks to their excellent photophysical properties, organic luminogens featuring aggregation-induced emission (AIE) characteristics (AIEgens) have attracted considerable attention over the past two decades. Because of superior biocompatibility, ease processing functionalization, water solubility, high responsiveness, exceptional signal-to-noise ratio (SNR) for biotargets, AIE bioconjugates, formed by covalently linking AIEgens with biomolecules, emerged as an ideal candidate bioapplications. In this review, we summarize progress preparation, application bioconjugates last five years. Moreover, challenges opportunities are also briefly discussed.
Language: Английский
Citations
0
Advanced Science, Journal Year: 2025, Volume and Issue: unknown
Published: April 15, 2025
Abstract Arterial thrombosis is a severe cardiovascular condition associated with high mortality and disability rates. Traditional pharmacological thrombolytic therapies, however, are limited by narrow therapeutic window, short drug half‐lives, restricted effectiveness, the risk of hemorrhagic complications. Moreover, unique biological microenvironment arterial characterized shear stress an inflammatory milieu rich in reactive oxygen species (ROS), resulting relatively recurrence rate. To address these challenges, mechanical biomimetic nanocomposite MPB‐NO‐UK@PM developed doping sodium nitroprusside, nitric oxide (NO) donor, into mesoporous Prussian blue (MPB) nanoparticles to form MPB‐NO, which then loaded urokinase (UK) coated platelet membranes (PM). The exhibits excellent thrombus‐targeting ability enhances efficacy through synergistic photothermal pharmacological, while simultaneously reducing bleeding. released NO induces antiplatelet aggregation effects, effectively scavenges ROS cytokines, thereby preventing thrombus recurrence. Additionally, possesses superior photoacoustic imaging capabilities, enabling visualization diagnosis treatment. This approach represents novel pathway for multidimensional efficient management thrombosis.
Language: Английский
Citations
0
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 4, 2024
Abstract Optically active ultrabright imaging agents are shown to delineate tumor location with deep tissue visualization in pre noclinical models. NanoGhosts (NGs) particles reconstructed from the cell membrane and integrated organic fluorophores attain ultra‐brightness for solid imaging. Moreover, integration of amphiphilic lipophilic molecules reveals structural characteristics NGs (≈70 nm), which also alter their brightness. Upon intravenous administration (10 mg kg −1 single dose), these (778 MESF) enable high‐resolution site real‐time tracking vital organs high‐contrast fluorescence signals. Engineered biomimetic demonstrates better resolution penetration as compared clinically approved indocyanine green (ICG). High precision detection (0.5 h) strong retention (24 h is further up 30 th day) without affecting healthy tissues ensure future scope early‐stage cancer These findings suggest that mimic biological native cells, enabling them evade immune clearance target naturally.
Language: Английский
Citations
2
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 7, 2024
Abstract The second near‐infrared window (NIR‐II) fluorescence imaging has aroused more and interest in biomedical applications due to negligible autofluorescence deep penetration ability. However, the quantum yield of NIR‐II fluorophores with than 1100 nm emission wavelength is typically less 1%, thus limiting quality tissues. In this study, a novel organic small molecule CTB1125 designed synthesized. Due an efficient intramolecular charge transfer (ICT) facilitated by high donor‐acceptor‐donor (D‐A‐D) strength structure, exhibits maximum 1125 nm. Additionally, branched alkyl chains are modified on conjugated fused ring backbone reduce intermolecular stacking. encapsulated amphiphilic copolymer PS 2000 ‐PEG form CTB1125‐NPs, which exhibit ultrahigh up 4.84% aqueous solution, excellent photostability, signal‐to‐noise rate. these outstanding properties, CTB1125‐NPs have been successfully used for clear long‐duration vessel amounts low laser power short exposure time, precisely guiding surgical resection tumors mice through imaging. This work provides promising fluorophore brightness deep‐tissue imaging‐guided surgery.
Language: Английский
Citations
0
Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 249, P. 114489 - 114489
Published: Dec. 30, 2024
Language: Английский
Citations
0