From Bench to Bedside: Advancing Liposomal Doxorubicin for Targeted Cancer Therapy

Results in Surfaces and Interfaces, Journal Year: 2025, Volume and Issue: unknown, P. 100473 - 100473

Published: March 1, 2025

Language: Английский

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Recent advances in biomimetic nanodelivery systems for cancer Immunotherapy

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101726 - 101726

Published: April 1, 2025

Language: Английский

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Zwitterionic Internalizable Peptide‐Drug Conjugates: Tumor‐Selective Ultrafast Uptake and Transcytosis for Enhanced Antitumor Therapy

Small, Journal Year: 2025, Volume and Issue: unknown

Published: April 14, 2025

Abstract Here a novel class of zwitterionic internalizable peptide (ZIP)‐drug conjugates is presented. The incorporate γ‐glutamyl‐α‐aminobutyrylamino‐functionalized lysine peptides as the ZIP backbones and disulfide‐linked camptothecin (CPT) toxic payload. ZIPs significantly enhance water solubility CPT without compromising its cytotoxicity. Cellular uptake profiling shows ultrafast internalization in tumor cells within 5 min. Mechanistic studies reveal that they enter via lipid raft‐mediated pathways, involving both energy‐driven active transport membrane fluidity‐dependent passive uptake. Furthermore, these exhibit robust transcytosis abilities across dense cell monolayers spheroids. These characteristics confer prolonged blood circulation, enhanced accumulation, deep penetration on conjugates, which result potent vivo antitumor activity minimal systemic toxicity. This study underscores potential for safer more effective cancer therapies presents new category molecularly defined delivery tools biomedical applications.

Language: Английский

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Cascade-Responsive Fe-Doped Carbon Dots for Enhanced Sentinel Lymph Node Biopsy and Postoperative Tumor Eradication in Breast Cancer Management

Published: Jan. 1, 2025

Language: Английский

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