A novel silkworm excrement-derived nanomedicine integrating ferroptosis and photodynamic therapy, well-suitable for PD-L1-mediated immune checkpoint blockade

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: 505, P. 159676 - 159676

Published: Jan. 17, 2025

Language: Английский

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Self-assembled nanodrug based on ferroptosis inducer and sonosensitizer for enhanced sonodynamic-triggered multimodal synergistic therapy of prostate cancer

European Journal of Pharmaceutics and Biopharmaceutics, Journal Year: 2025, Volume and Issue: 208, P. 114656 - 114656

Published: Feb. 3, 2025

Language: Английский

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Metal-organic coordinated self-assembled nanomedicine for enhanced cuproptosis-mediated chemo-photo-chemodynamic synergistic therapy of non-small cell lung cancer

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161305 - 161305

Published: March 1, 2025

Language: Английский

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Epsilon-Polylysine Microneedle Potentiating MXene-Mediated Photothermal Ablation for Combating Antibiotic-Resistant Bacterial Infections

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101498 - 101498

Published: Jan. 19, 2025

Antimicrobial peptides show promise in enhancing photothermal therapy, but their application is often limited by the challenge of constructing a delivery system that balances efficacy and safety. Our research demonstrated bactericidal V2C MXene-mediated therapy enhanced concentration-dependent relationship with introduction coating antimicrobial peptide ε-polylysine (EPL). EPL exhibited dual role bacterial binding disrupting membranes, thereby increasing heat transfer efficiency reducing resistance to ablation. The core strategy this study was exploit combined membranolytic-photothermal effect extensively applying while regulating nanosheets usage prevent overheating. This approach aims achieve potent through below 60 °C. Consequently, we developed dissolving microneedles incorporated nanosheets, where served as agent primary matrix, its loading capacity minimizing need for inactive excipients. Notably, microneedle achieved 99.9 % reduction abundance methicillin-resistant Staphylococcus aureus on infected skin after single resulted 92-fold load compared group treated commercial Bactroban ointment, no apparent toxicity mice.

Language: Английский

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Precise HER2 Protein Degradation via Peptide‐Conjugated Photodynamic Therapy for Enhanced Breast Cancer Immunotherapy

Advanced Science, Journal Year: 2024, Volume and Issue: 12(2)

Published: Nov. 18, 2024

Abstract Breast cancer, the most prevalent malignancy among women, frequently exhibits high HER2 expression, making a critical therapeutic target. Traditional treatments combining anti‐HER2 antibody trastuzumab with immunotherapy face limitations due to toxicity and tumor microenvironment immunosuppression. This study introduces an innovative strategy HER2‐targeting peptides photosensitizer (PSs) pyropheophorbide‐a (Pha) via gelatinase‐cleavable linker, forming self‐assembling nanoparticles. These nanoparticles actively target breast cancer cells generate reactive oxygen species (ROS) under near‐infrared light, effectively degrading proteins. Upon internalization, linker is cleaved, releasing Pha‐PLG enhancing intracellular photodynamic therapy (PDT). The molecules self‐assemble into nanofibers, prolonging circulation, boosting immune induction, activating CD8 + T cells, thus promoting robust anti‐tumor response. In vivo, studies confirm superior biosafety, targeting, degradation, increased cytotoxic cell activity improved antitumor immunity. integrated offers promising new avenue for treatment.

Language: Английский

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An artificial-enzyme-equipped immunoregulator blocks platelet-mediated breast cancer hematogenous metastasis

Biomaterials, Journal Year: 2025, Volume and Issue: 322, P. 123380 - 123380

Published: April 30, 2025

Language: Английский

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Nanotherapeutics for Macrophage Network Modulation in Tumor Microenvironments: Targets and Tools

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 13615 - 13651

Published: Dec. 1, 2024

Macrophage is an important component in the tumor immune microenvironment, which exerts significant influence on development and metastasis. Due to their dual nature of promoting suppressing inflammation, macrophages can serve as both targets for immunotherapy tools treating malignancies. However, abundant infiltration tumor-associated dominated by immunosuppressive phenotype maintains a pro-tumor engineering using nanotechnology manipulate microenvironment represent feasible approach cancer immunotherapy. Additionally, considering phagocytic specifically tumor-targeting capabilities M1 macrophages, manipulated through cellular nanotechnology, well macrophage-derived exosomes macrophage membranes, also become effective treatment. In conclusion, nanotherapeutics targeting remains immense potential macrophage-mediated treatment methods will further enhance our understanding, diagnosis, various malignants.

Language: Английский

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A novel nanomedicine integrating ferroptosis and photothermal therapy, well-suitable for PD-L1-mediated immune checkpoint blockade

Materials Today Bio, Journal Year: 2024, Volume and Issue: 29, P. 101346 - 101346

Published: Nov. 16, 2024

Language: Английский

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Versatile Carrier-Free Binary Nanodrugs Based on Metformin/Epigallocatechin Gallate Nanoparticles: Exploring Its Properties and Potential in Cancer Treatment†

Biomaterials Science, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 20, 2024

Epigallocatechin gallate (EGCG), an important active component extracted from green tea, has attracted much attention due to its multiple biological activities such as antioxidant, antibacterial, anti-inflammatory, and antitumor effects.

Language: Английский

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