Shedding light on vascular imaging: the revolutionary role of nanotechnology DOI Creative Commons
Peisen Zhang, Li Yao, Xiaoqi Li

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Dec. 18, 2024

Vascular dysfunction, characterized by changes in anatomy, hemodynamics, and molecular expressions of vasculatures, is closely linked to the onset development diseases, emphasizing importance its detection. In clinical practice, medical imaging has been utilized as a significant tool assessment vascular however, traditional techniques still lack sufficient resolution for visualizing complex microvascular systems. Over past decade, with rapid advancement nanotechnology emergence corresponding detection facilities, engineered nanomaterials offer new alternatives contrast agents. Compared conventional small molecule counterparts, possess numerous advantages imaging, holding potential significantly advance related technologies. this review, latest developments nanotechnology-assisted research across different modalities, including contrast-enhanced magnetic resonance (MR) angiography, susceptibility-weighted (SWI), fluorescence second near-infrared window (NIR-II) are summarized. Additionally, advancements preclinical studies these nanotechnology-enhanced approaches outlined, subsequent discussion on current challenges future prospects both basic translation.

Language: Английский

Adjusting Morphology, Structure, and Mechanical Properties of Electrospun High‐Molecular‐Weight Poly(l‐Lactic‐Acid) Nanofibrous Yarns Through Hot Stretching Treatment DOI Open Access

Xiaoyu Liu,

Jiayi Jiang, Hailei Liu

et al.

Macromolecular Bioscience, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 22, 2025

Abstract An integrated strategy that combines innovative electrospinning technique with traditional hot‐stretching post‐treatment is designed and implemented to generate high‐molecular‐weight poly(l‐lactic‐acid) (hmwPLLA, Mw = 2 80 000 Da) electrospun nanofiber‐constructed yarns (ENCYs). The internal fiber diameter within the hmwPLLA ENCYs found increase gradually of solution concentration. ENCY generated from a concentration 10% (w v −1 ) demonstrated uniform morphology an average 737.7 ± 72.2 nm yarn 454.9 3.5 µm. Compared unstretched ENCY, increasing temperature can significantly enhance orientation crystallinity. Moreover, mechanical properties stretched are obviously enhanced compared control. crystallinity also be improved hot stretching rate, further resulting in obvious breaking strength Young's modulus. Importantly, braided textiles made exhibited great biocompatibility by effectively guiding cell alignment supporting adhesion proliferation. In summary, high performance show potential for future design development advanced biomedical textiles.

Language: Английский

Citations

2
Application of Nanomaterials in Early Imaging and Advanced Treatment of Atherosclerosis DOI Creative Commons
Qun Zhou, Yujie Wang, Guangxiang Si

et al.

Chemical & Biomedical Imaging, Journal Year: 2025, Volume and Issue: 3(2), P. 51 - 76

Published: Jan. 21, 2025

Atherosclerosis (AS) is a serious disease that poses significant threat to the global population. In this review, we analyze development of AS from multiple perspectives, aiming elucidate its molecular mechanisms. We also focus on imaging techniques and therapeutic approaches, highlighting crucial role nanomaterials in both therapy for AS. By leveraging their compatibility targeting capabilities, can be integrated with traditional medical agents achieve targeted drug delivery, controlled release, precise localization atherosclerotic plaques.

Language: Английский

Citations

0
Subnanometer ultra-thin magnetic nanosheets for highly sensitive magnetic resonance angiography DOI
Kun Liu, Na Yang,

C. BO

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160808 - 160808

Published: Feb. 1, 2025

Language: Английский

Citations

0
Nanomaterial Technologies for Precision Diagnosis and Treatment of Brain Hemorrhage DOI
Peisen Zhang,

Y. Ran,

Lei Han

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: unknown, P. 123269 - 123269

Published: March 1, 2025

Language: Английский

Citations

0
Delayed Magnetic Resonance Imaging of Alzheimer’s Disease by Using Poly(2-(methacryloyloxy)ethyl phosphorylcholine)-Functionalized Nanoprobes DOI
Wenyue Li, Xinyi Zhang, Chuang Liu

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(50), P. 69045 - 69054

Published: Dec. 5, 2024

Alzheimer's disease (AD) is one of the most common neurodegenerative diseases, commonly affecting aged, with pathophysiological changes presenting 15 to 20 years before clinical symptoms. Early diagnosis and intervention are crucial in effectively slowing progression AD. In current study, poly(2-(methacryloyloxy)ethyl phosphorylcholine) (PMPC)-functionalized NaGdF4 nanoparticles (NaGdF4-PMPC) were developed as magnetic resonance imaging (MRI) contrast agents for targeting alpha 7 nicotinic acetylcholine receptors (α7 nAChRs) AD mice. NaGdF4-PMPC showed excellent biocompatibility, ability, MRI performance, longitudinal molar relaxivity (r1) transverse (r2) being 1.21-fold 1.33-fold higher than those agent Gd-DTPA, respectively, resulting higher-sensitive MR angiography. After intravenous injection, 3D dynamic contrast-enhanced (DCE) images high-resolution vasculature mouse brain obtained. addition, by using NaGdF4-PMPC, susceptibility-weighted (SWI) signals brains greatly retained compared healthy mice 24 h, emphasizing ability NaGdF4-PMPC. Furthermore, CD31, α7 nAChRs, Thioflavin S staining also utilized investigate relationship among vascular inflammation, amyloid-β (Aβ) deposition This work highlights a promising targeted strategy timely

Language: Английский

Citations

1
Shedding light on vascular imaging: the revolutionary role of nanotechnology DOI Creative Commons
Peisen Zhang, Li Yao, Xiaoqi Li

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Dec. 18, 2024

Vascular dysfunction, characterized by changes in anatomy, hemodynamics, and molecular expressions of vasculatures, is closely linked to the onset development diseases, emphasizing importance its detection. In clinical practice, medical imaging has been utilized as a significant tool assessment vascular however, traditional techniques still lack sufficient resolution for visualizing complex microvascular systems. Over past decade, with rapid advancement nanotechnology emergence corresponding detection facilities, engineered nanomaterials offer new alternatives contrast agents. Compared conventional small molecule counterparts, possess numerous advantages imaging, holding potential significantly advance related technologies. this review, latest developments nanotechnology-assisted research across different modalities, including contrast-enhanced magnetic resonance (MR) angiography, susceptibility-weighted (SWI), fluorescence second near-infrared window (NIR-II) are summarized. Additionally, advancements preclinical studies these nanotechnology-enhanced approaches outlined, subsequent discussion on current challenges future prospects both basic translation.

Language: Английский

Citations

0