Donor Modulation Brings All-In-One Phototheranostics for NIR-II Imaging-Guided Type-I Photodynamic/Photothermal Synergistic Cancer Therapy

Chemical Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

A novel all-in-one phototheranostics OTAB was synthesized by modifying the donor and regulating band gap for NIR-II imaging-guided synergistic type-I PDT/PTT therapy.

Language: Английский

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Inverse Oxide/Alloy‐Structured Nanozymes with NIR‐Triggered Enzymatic Cascade Regulation of ROS Homeostasis for Efficient Wound Healing

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

The precise spatiotemporal control of reactive oxygen species (ROS) generation and scavenging remains pivotal for infected wound healing. However, conventional nanozymes fail to adaptively regulate ROS dynamics across inflammatory proliferative phases. A near-infrared (NIR)-activated inverse oxide/alloy-structured nanozyme (Co7Fe3/ZnO@C) is developed, featuring enzymatic cascade activities tune homeostasis through synergistic chemodynamic (CDT), photodynamic (PDT), photothermal (PTT) therapies. orchestrates a self-regulated cascade: peroxidase (POD)-like activity initially generates bactericidal hydroxyl radicals in acidic wounds, while subsequent NIR triggers hot electron transfer from Co7Fe3 ZnO, facilitating synchronized superoxide dismutase (SOD)-like, catalase (CAT)-like radical antioxidant capacity (HORAC) scavenge residual ROS. This cascaded network dynamically balances production (POD) (NIR-driven SOD/CAT/HORAC), eradicating bacteria resolving inflammation. In vitro/vivo studies have shown that the proposed method maintaining can markedly enhance rate healing by regulation environment within injured tissue facilitation rapid re-epithelialization. work provides an intelligent platform simulates function natural enzymes constructs reaction strategy balance antibacterial anti-inflammatory demands microenvironment.

Language: Английский

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Giant Enhancement of Optical Nonlinearity by Manipulating Guest Molecular Stacking Modes in Metal–Organic Frameworks

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

The influence of guest stacking interactions in host-guest (H-G) MOF composites on third-order nonlinear optical (NLO) performance remains largely unknown. Herein, we propose for the first time a noncovalent aggregate confinement strategy synthesizing H-G with different modes. And [perylene2]n (α-Pe) and [perylene]n (β-Pe) were selected as guests confined into novel Ca-based {[Ca(TBAPy)(DMA)2]·3DMA·[N(CH3)2]·H2O}n (Ca-MOF-pts). NLO results showed that compared to β-Pe@Ca-MOF-pts, saturable absorption (SA) self-defocusing properties α-Pe@Ca-MOF-pts increased by 2.71-fold 3.82-fold, respectively. Interestingly, α/β-Pe@Ca-MOF-pts can be transformed α/β-Pe@Ca-MOF-flu (Ca-MOF-flu = {[Ca1.5(TBAPy)(H2O)2]·DMA·[N(CH3)2]·2H2O}n) through self-adaptive topological evolution, corresponding signal change from SA reverse (RSA). As expected, β-Pe@Ca-MOF-flu, RSA α-Pe@Ca-MOF-flu are improved 2.94-fold 4.07-fold, respectively, demonstrating importance Theoretical calculation transient spectra indicated enhancement was attributed large π-π overlap α-Pe, which promoted electron delocalization/transfer optimized cross-sectional ground state excited state. This study provides new developing excellent properties.

Language: Английский

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Atomic Engineering and Aggregation Effect to Regulate Synergistically Type I Reactive Oxygen Species of AIE‐Active Deep Red/Near Infrared Red Photosensitizer

Small, Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Abstract “Molecular science” has long been regarded as the golden rule to guide design of organic materials’ performances in past many years, but some interesting phenomena conventional aggregation‐caused fluorescence quenching and new aggregation‐induced emission reflect that properties would be changed from “molecule” “aggregate”. Therefore, “molecular theory faces certain limitations regulating performance materials at aggregation. In this work, it is discovered photosensitizer's contain reactive oxygen species, which could affected by changing molecular atoms aggregation form. The introduction selenium redshift improve species (ROS) efficiency. addition atomic effect, ROS efficiency photosensitizers after coating a polymeric shell, is, production type II singlet ( 1 O 2 ) suppressed, while I superoxide anion (O −• improved. This work discovers are relevant effect discussing deeply influence mechanism, important research significance for modulating precisely promoting development photodynamic therapy.

Language: Английский

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Photoirradiation‐ and Extracellular‐Matrix‐Encouraged Photon‐Transition Switching Regulates Spatiotemporal Sequential Photoimmunotherapy

Small Structures, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

As two main phototherapy means, photodynamic therapy (PDT) and photothermal (PTT) have different photon‐transition avenues decided by the aggregation state of photosensitizers (PSs), thus PDT or PTT efficiency can be regulated regulating PSs aggregation. A co‐assembly formulation consisting IR780 iodide pentafluorophenyl trifluoroacetate is constructed through intermolecular interactions, followed coating with hyaluronic acid. Initially, uniform distribution favors more reactive oxygen species birth to implement when entering cells since its avenue sequential process intersystem crossing transfer–collision energy transfer predominant. After hyaluronidase laser irradiation‐induced structural collapse co‐assembly, free aggregates due hydrophobic interactions even though they are excreted out cells, then, these produce heat nonradiative relaxation execute PTT. Such a spatiotemporal PDT–PTT encourages antitumor immune responses mitigates immunosuppression, accomplishing photoimmunotherapy against breast cancer progression. Through such tumor microenvironment‐adaptable laser‐duration‐decided alteration, switching insights provided into single PSs‐mediated photoimmunotherapy.

Language: Английский

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Recent Advances in NIR-II Molecular Aggregates and Applications in the Biomedical Field

Chemosensors, Journal Year: 2025, Volume and Issue: 13(2), P. 67 - 67

Published: Feb. 13, 2025

Near-infrared (NIR) light is a promising tool for biomedical imaging and therapy, offering excellent tissue penetration, low scattering, minimal biological fluorescence interference. An NIR-II optical range of 900–1880 nm with reduced background interference particularly useful disease diagnosis treatment. Probes based on organic molecules are gaining attention their structural flexibility stable performance. Organic molecular aggregates, such as J-aggregates, H-aggregates, aggregation-induced emission (AIE)-aggregates, exhibit unique properties like tunable spectral shifts, improved photostability, higher absorption quantum yields. This mini review briefly discusses the advancements in therapy technologies, focusing classification, formation mechanisms, applications aggregates treatment, theoretical foundation practical guidance future research.

Language: Английский

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A Bacteria-Targeting Supramolecular Nanophotosensitizer for Combating Multidrug Resistant Bacteria

ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

The increasing prevalence of multidrug-resistant bacteria is a significant global health threat. In contrast to conventional antibiotic treatments, photodynamic therapy (PDT) offers promising alternative by reducing the bacterial adaptability antibiotics and bactericides. However, traditional photosensitizers encounter poor antimicrobial efficacy due hydrophilicity photosensitizers, short lifespan, narrow diffusion radius reactive oxygen species (ROS), risk exacerbating inflammation. this study, we report bacterial-targeting supramolecular nanophotosensitizer for combating multidrug resistant bacteria. nanophotosensitizer, formed through host–guest interactions self-assembly tetra-cyclodextrin-modified silver porphyrin (AgTPP-CD4), adamantyl-modified phenylboronic acid (Ad-PBA), curcumin (Cur), can effectively target kill methicillin-resistant Staphylococcus aureus (MRSA). Moreover, it reduces inflammation promotes wound healing in MRSA-infected wounds without inducing drug resistance. combination chemistry targeted PDT strategy infections.

Language: Английский

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Bilateral Synergistic Effects of Phototherapy‐Based NIR‐II Absorption Photosensitizer for Allergic Rhinitis

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 21, 2025

Abstract Allergic rhinitis (AR) is the most prevalent global health issue, affecting approximately 3 billion people, with its incidence increasing annually. The current first‐line pharmacotherapy for symptom relief has limited efficacy and often results in notable side effects. Here, aza‐BODIPY‐based nanoparticles (RH@NPs) are developed that exhibit mild photothermal therapy (PTT) type I photodynamic (PDT) capabilities. Enhanced intramolecular charge transfer induces NIR‐II absorption of photosensitizer (RH), facilitating deeper tissue penetration augmented AR therapy. Additionally, use an asymmetric donor–acceptor–acceptor′ configuration promotes self‐assembly RH, enhancing intersystem crossing ability enabling efficient photophysical activity. synergistic effects PTT (enhancing HSF1 DNA‐binding activity to inhibit epithelial‐mesenchymal transition by epigenetically regulating expression transition‐associated genes) PDT (activating NRF2 transcriptional stimulate antioxidant defense system) enable RH@NPs provide a superior therapeutic effect mouse model AR. This achieved mechanically reducing allergic response rather than merely alleviating symptoms. Notably, photosensitizer‐based physical demonstrates enhanced safety. study first successfully investigate application phototherapy elucidate mechanism action, offering novel, straightforward, treatment strategy

Language: Английский

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Near‐Infrared Multiple‐Resonance Polycyclic Aromatic Hydrocarbon as Type I Photosensitizer Toward High‐Performance Synergistic Phototherapy

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 23, 2025

Abstract Type I photosensitization is of particular significance in the anaerobic tumor treatment. Nonetheless, development high‐performance type photosensitizers (PSs) remains challenging, due to weak absorption and inefficient intersystem crossing (ISC) progress. Herein, an effective approach toward a near‐infrared (NIR) PS ( NIR‐BN ) demonstrated using boron/nitrogen‐embedded polycyclic aromatic hydrocarbon with multiple‐resonance (MR) character, for first time. A small singlet‐triplet splitting (Δ E ST = 0.09 eV) high molar extinction coefficient (3.3 × 10 4 M −1 cm NIR MR‐configured supports efficient ISC triplet sensitization. The distorted molecular configurations induce multi‐model structural relaxations after optical excitation, resulting remarkable photothermal conversion efficiency exceeding 50% nanoparticles. Of note, nanoparticles are capable generating highly toxic superoxide anion radical (O 2 •− under 660 nm laser irradiation, benefiting from vigorous intramolecular dihedral angle vibrations excited states. Consequently, biocompatible demonstrates superior performance vivo synergistic photodynamic therapies.

Language: Английский

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High‐Efficiency Organic Semiconducting Small Molecule for Deep‐Tissue Phototheranostics: Single 1064 nm Laser Triggered NIR‐IIb Fluorescence Imaging Guided Type‐I Photodynamic/Photothermal Combination Therapy

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Abstract Organic semiconducting small molecules that simultaneously possess NIR‐IIb (1500–1700 nm) fluorescence imaging (FLI), hypoxia‐tolerant photodynamic therapy (PDT) as well photothermal (PTT) abilities activated by a single NIR‐II (1000‐1700 light can achieve high‐performance deep‐tissue phototheranostics, but have not gain much attention. Herein, novel organic molecule (DTT) with an absorption maximum at 844 nm and emission 944 in its monomer state is synthesized through delicate molecular design. Surprisingly, the spectrum of DTT extend into region. Subsequently, phototheranostic nanoparticles (DTT NPs) dramatically red‐shifted absorption/emission peak (1029/1128 are skillfully developed based on J ‐aggregation strategy, which show greatly high molar absorptivity Upon 1064 excitation, resolution FLI be achieved whole‐body vessels, cerebral vasculatures, tumors living mice treated NPs. Moreover, NPs also produce type‐I reactive oxygen species hyperthermia under laser irradiation for oxygen‐less‐dependent PDT PTT combination therapy, eventually achieving efficient antitumor effects. This work provides facile strategy designing high‐efficiency phototheranostics.

Language: Английский

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