The Current Advances in Design Strategy (Indirect Strategy and Direct Strategy) for Type‐I Photosensitizers DOI Creative Commons
Ning Ma,

Junjie Wang,

Hui Tang

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 25, 2024

Type-I photosensitizers (PSs) are among the most potential candidates for photodynamic therapy (PDT), as their low dependence on oxygen endow them with many advantages treating hypoxic tumor. However, of reported type-I PSs have a contingency molecular design, because electron transfer (ET) reaction is more difficult to achieve than energy (EET) process. Therefore, it urgent understand design mechanisms PSs. In this review, two ways PSs, i.e., inhibiting EET process (type-II) or enhancing ET (type-I), detailly explained. response, current strategies summarized from perspectives: indirect strategy (inhibiting process: reducing lowest triplet excited state (T

Language: Английский

Donor Modulation Brings All-In-One Phototheranostics for NIR-II Imaging-Guided Type-I Photodynamic/Photothermal Synergistic Cancer Therapy DOI Creative Commons
Yuxin Ren, Xinyi Zhang, Ling Li

et al.

Chemical Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

A novel all-in-one phototheranostics OTAB was synthesized by modifying the donor and regulating band gap for NIR-II imaging-guided synergistic type-I PDT/PTT therapy.

Language: Английский

Citations

2

Inverse Oxide/Alloy‐Structured Nanozymes with NIR‐Triggered Enzymatic Cascade Regulation of ROS Homeostasis for Efficient Wound Healing DOI Open Access

Yongsen Zhao,

Shiqi Zhao, Yu Du

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

The precise spatiotemporal control of reactive oxygen species (ROS) generation and scavenging remains pivotal for infected wound healing. However, conventional nanozymes fail to adaptively regulate ROS dynamics across inflammatory proliferative phases. A near-infrared (NIR)-activated inverse oxide/alloy-structured nanozyme (Co7Fe3/ZnO@C) is developed, featuring enzymatic cascade activities tune homeostasis through synergistic chemodynamic (CDT), photodynamic (PDT), photothermal (PTT) therapies. orchestrates a self-regulated cascade: peroxidase (POD)-like activity initially generates bactericidal hydroxyl radicals in acidic wounds, while subsequent NIR triggers hot electron transfer from Co7Fe3 ZnO, facilitating synchronized superoxide dismutase (SOD)-like, catalase (CAT)-like radical antioxidant capacity (HORAC) scavenge residual ROS. This cascaded network dynamically balances production (POD) (NIR-driven SOD/CAT/HORAC), eradicating bacteria resolving inflammation. In vitro/vivo studies have shown that the proposed method maintaining can markedly enhance rate healing by regulation environment within injured tissue facilitation rapid re-epithelialization. work provides an intelligent platform simulates function natural enzymes constructs reaction strategy balance antibacterial anti-inflammatory demands microenvironment.

Language: Английский

Citations

2

Atomic Engineering and Aggregation Effect to Regulate Synergistically Type I Reactive Oxygen Species of AIE‐Active Deep Red/Near Infrared Red Photosensitizer DOI Open Access

Y. H. Zheng,

Yin Li, Xue Bai

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Abstract “Molecular science” has long been regarded as the golden rule to guide design of organic materials’ performances in past many years, but some interesting phenomena conventional aggregation‐caused fluorescence quenching and new aggregation‐induced emission reflect that properties would be changed from “molecule” “aggregate”. Therefore, “molecular theory faces certain limitations regulating performance materials at aggregation. In this work, it is discovered photosensitizer's contain reactive oxygen species, which could affected by changing molecular atoms aggregation form. The introduction selenium redshift improve species (ROS) efficiency. addition atomic effect, ROS efficiency photosensitizers after coating a polymeric shell, is, production type II singlet ( 1 O 2 ) suppressed, while I superoxide anion (O −• improved. This work discovers are relevant effect discussing deeply influence mechanism, important research significance for modulating precisely promoting development photodynamic therapy.

Language: Английский

Citations

2

Giant Enhancement of Optical Nonlinearity by Manipulating Guest Molecular Stacking Modes in Metal–Organic Frameworks DOI

Kangshuai Geng,

Yupei Sun,

Yujie Zhao

et al.

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

The influence of guest stacking interactions in host-guest (H-G) MOF composites on third-order nonlinear optical (NLO) performance remains largely unknown. Herein, we propose for the first time a noncovalent aggregate confinement strategy synthesizing H-G with different modes. And [perylene2]n (α-Pe) and [perylene]n (β-Pe) were selected as guests confined into novel Ca-based {[Ca(TBAPy)(DMA)2]·3DMA·[N(CH3)2]·H2O}n (Ca-MOF-pts). NLO results showed that compared to β-Pe@Ca-MOF-pts, saturable absorption (SA) self-defocusing properties α-Pe@Ca-MOF-pts increased by 2.71-fold 3.82-fold, respectively. Interestingly, α/β-Pe@Ca-MOF-pts can be transformed α/β-Pe@Ca-MOF-flu (Ca-MOF-flu = {[Ca1.5(TBAPy)(H2O)2]·DMA·[N(CH3)2]·2H2O}n) through self-adaptive topological evolution, corresponding signal change from SA reverse (RSA). As expected, β-Pe@Ca-MOF-flu, RSA α-Pe@Ca-MOF-flu are improved 2.94-fold 4.07-fold, respectively, demonstrating importance Theoretical calculation transient spectra indicated enhancement was attributed large π-π overlap α-Pe, which promoted electron delocalization/transfer optimized cross-sectional ground state excited state. This study provides new developing excellent properties.

Language: Английский

Citations

1

Exploring the principles and applications of non-metal photothermal catalysts: Insights from mechanistic differences with metal counterparts DOI
Yaocheng Deng, Huiling Liu,

Zhanpeng Zhou

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 534, P. 216579 - 216579

Published: March 6, 2025

Language: Английский

Citations

1

“Mix‐and‐Match”: Self‐Sorting Assembly Governed Supramolecular Polymeric Nanomedicine for Boosting Combined Chemo/Phototherapy DOI

Yanggui Wu,

Ting Li,

Zeke Li

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Abstract Precise cancer nanomedicine requires rational molecular instructions of therapeutic agents. Harnessing the structure‐property‐function relationships represents a practical strategy toward smart and effective nanomedicine. A structurally novel hydrogen‐bonded (H‐bonded) supramolecular nanoformulation generated by orthogonal self‐sorting assembly chemo‐prodrug (FPtF) phototherapeutics (BPeB) is here reported, to reach an autonomous with improved anti‐tumor efficacy combining chemo/phototherapy (CT/PT). The high‐fidelity H‐bonding modularity from privileged heterocomplementary diaminopyridine/5‐fluorouracil (DAP/FU) Hamilton wedge/barbiturate (HW/Ba) pairs, respectively enable precise spatial control binding interactions FPtF BPeB, in turn allowing process specific “mix‐and‐match” capability. To directly stimulate phototherapy BPeB via near‐infrared (NIR) light, spectral matched upconversion nanoparticles (UCNPs, β‐NaYF 4 :Yb,Er) are encapsulated simultaneously. As result, polymeric nanomicelles, i.e., F/B/U@PHDO, readily fabricated. Moreover, distinct association constant (Ka) DAP/FU (≈10 2 M −1 ) HW/Ba 4‐5 pairs reflect different strengths stabilities H‐bonds, thus endowing programmable dissociation, accompanied release through pH/thermal‐stimuli. Therapeutic regime appreciated outcomes ultimately accomplished combined CT/PT. opportunities offered design anticipated point new paradigm for therapy.

Language: Английский

Citations

1

Photoirradiation‐ and Extracellular‐Matrix‐Encouraged Photon‐Transition Switching Regulates Spatiotemporal Sequential Photoimmunotherapy DOI Creative Commons
Hai Wang,

Feixiang Hu,

Wuyang Wei

et al.

Small Structures, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

As two main phototherapy means, photodynamic therapy (PDT) and photothermal (PTT) have different photon‐transition avenues decided by the aggregation state of photosensitizers (PSs), thus PDT or PTT efficiency can be regulated regulating PSs aggregation. A co‐assembly formulation consisting IR780 iodide pentafluorophenyl trifluoroacetate is constructed through intermolecular interactions, followed coating with hyaluronic acid. Initially, uniform distribution favors more reactive oxygen species birth to implement when entering cells since its avenue sequential process intersystem crossing transfer–collision energy transfer predominant. After hyaluronidase laser irradiation‐induced structural collapse co‐assembly, free aggregates due hydrophobic interactions even though they are excreted out cells, then, these produce heat nonradiative relaxation execute PTT. Such a spatiotemporal PDT–PTT encourages antitumor immune responses mitigates immunosuppression, accomplishing photoimmunotherapy against breast cancer progression. Through such tumor microenvironment‐adaptable laser‐duration‐decided alteration, switching insights provided into single PSs‐mediated photoimmunotherapy.

Language: Английский

Citations

0

Recent Advances in NIR-II Molecular Aggregates and Applications in the Biomedical Field DOI Creative Commons

Kun Wu,

Rong Yang,

Xuefang Song

et al.

Chemosensors, Journal Year: 2025, Volume and Issue: 13(2), P. 67 - 67

Published: Feb. 13, 2025

Near-infrared (NIR) light is a promising tool for biomedical imaging and therapy, offering excellent tissue penetration, low scattering, minimal biological fluorescence interference. An NIR-II optical range of 900–1880 nm with reduced background interference particularly useful disease diagnosis treatment. Probes based on organic molecules are gaining attention their structural flexibility stable performance. Organic molecular aggregates, such as J-aggregates, H-aggregates, aggregation-induced emission (AIE)-aggregates, exhibit unique properties like tunable spectral shifts, improved photostability, higher absorption quantum yields. This mini review briefly discusses the advancements in therapy technologies, focusing classification, formation mechanisms, applications aggregates treatment, theoretical foundation practical guidance future research.

Language: Английский

Citations

0

A Bacteria-Targeting Supramolecular Nanophotosensitizer for Combating Multidrug Resistant Bacteria DOI
Wenlong Huang,

Anan Wang,

Wang Wen-chen

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

The increasing prevalence of multidrug-resistant bacteria is a significant global health threat. In contrast to conventional antibiotic treatments, photodynamic therapy (PDT) offers promising alternative by reducing the bacterial adaptability antibiotics and bactericides. However, traditional photosensitizers encounter poor antimicrobial efficacy due hydrophilicity photosensitizers, short lifespan, narrow diffusion radius reactive oxygen species (ROS), risk exacerbating inflammation. this study, we report bacterial-targeting supramolecular nanophotosensitizer for combating multidrug resistant bacteria. nanophotosensitizer, formed through host–guest interactions self-assembly tetra-cyclodextrin-modified silver porphyrin (AgTPP-CD4), adamantyl-modified phenylboronic acid (Ad-PBA), curcumin (Cur), can effectively target kill methicillin-resistant Staphylococcus aureus (MRSA). Moreover, it reduces inflammation promotes wound healing in MRSA-infected wounds without inducing drug resistance. combination chemistry targeted PDT strategy infections.

Language: Английский

Citations

0

Bilateral Synergistic Effects of Phototherapy‐Based NIR‐II Absorption Photosensitizer for Allergic Rhinitis DOI Open Access
Tao Shao, Lu Han, Yang Xie

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 21, 2025

Abstract Allergic rhinitis (AR) is the most prevalent global health issue, affecting approximately 3 billion people, with its incidence increasing annually. The current first‐line pharmacotherapy for symptom relief has limited efficacy and often results in notable side effects. Here, aza‐BODIPY‐based nanoparticles (RH@NPs) are developed that exhibit mild photothermal therapy (PTT) type I photodynamic (PDT) capabilities. Enhanced intramolecular charge transfer induces NIR‐II absorption of photosensitizer (RH), facilitating deeper tissue penetration augmented AR therapy. Additionally, use an asymmetric donor–acceptor–acceptor′ configuration promotes self‐assembly RH, enhancing intersystem crossing ability enabling efficient photophysical activity. synergistic effects PTT (enhancing HSF1 DNA‐binding activity to inhibit epithelial‐mesenchymal transition by epigenetically regulating expression transition‐associated genes) PDT (activating NRF2 transcriptional stimulate antioxidant defense system) enable RH@NPs provide a superior therapeutic effect mouse model AR. This achieved mechanically reducing allergic response rather than merely alleviating symptoms. Notably, photosensitizer‐based physical demonstrates enhanced safety. study first successfully investigate application phototherapy elucidate mechanism action, offering novel, straightforward, treatment strategy

Language: Английский

Citations

0