Organic NIR‐II Nanofluorophore with Ultrahigh Quantum Yield for Vessels Imaging and Fluorescence Image‐Guided Surgery DOI
Xinyi Zhang, Ling Li, Yuxin Ren

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 7, 2024

Abstract The second near‐infrared window (NIR‐II) fluorescence imaging has aroused more and interest in biomedical applications due to negligible autofluorescence deep penetration ability. However, the quantum yield of NIR‐II fluorophores with than 1100 nm emission wavelength is typically less 1%, thus limiting quality tissues. In this study, a novel organic small molecule CTB1125 designed synthesized. Due an efficient intramolecular charge transfer (ICT) facilitated by high donor‐acceptor‐donor (D‐A‐D) strength structure, exhibits maximum 1125 nm. Additionally, branched alkyl chains are modified on conjugated fused ring backbone reduce intermolecular stacking. encapsulated amphiphilic copolymer PS 2000 ‐PEG form CTB1125‐NPs, which exhibit ultrahigh up 4.84% aqueous solution, excellent photostability, signal‐to‐noise rate. these outstanding properties, CTB1125‐NPs have been successfully used for clear long‐duration vessel amounts low laser power short exposure time, precisely guiding surgical resection tumors mice through imaging. This work provides promising fluorophore brightness deep‐tissue imaging‐guided surgery.

Language: Английский

Molecularly Engineered NIR-II Emitting Carbon Dots Assemblies for Unprecedented High-Resolution Angiography and Synergistic Photodynamic/Photothermal Tumor Therapy DOI

Xiaokuang Xue,

Jian Li,

Tiejin Chen

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: 505, P. 159356 - 159356

Published: Jan. 7, 2025

Language: Английский

Citations

1
High‐Efficiency Organic Semiconducting Small Molecule for Deep‐Tissue Phototheranostics: Single 1064 nm Laser Triggered NIR‐IIb Fluorescence Imaging Guided Type‐I Photodynamic/Photothermal Combination Therapy DOI Open Access
Qi Wang, Jiawei Liu,

Linqiang Yang

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Abstract Organic semiconducting small molecules that simultaneously possess NIR‐IIb (1500–1700 nm) fluorescence imaging (FLI), hypoxia‐tolerant photodynamic therapy (PDT) as well photothermal (PTT) abilities activated by a single NIR‐II (1000‐1700 light can achieve high‐performance deep‐tissue phototheranostics, but have not gain much attention. Herein, novel organic molecule (DTT) with an absorption maximum at 844 nm and emission 944 in its monomer state is synthesized through delicate molecular design. Surprisingly, the spectrum of DTT extend into region. Subsequently, phototheranostic nanoparticles (DTT NPs) dramatically red‐shifted absorption/emission peak (1029/1128 are skillfully developed based on J ‐aggregation strategy, which show greatly high molar absorptivity Upon 1064 excitation, resolution FLI be achieved whole‐body vessels, cerebral vasculatures, tumors living mice treated NPs. Moreover, NPs also produce type‐I reactive oxygen species hyperthermia under laser irradiation for oxygen‐less‐dependent PDT PTT combination therapy, eventually achieving efficient antitumor effects. This work provides facile strategy designing high‐efficiency phototheranostics.

Language: Английский

Citations

0
Pyrrolopyrrole Cyanine-Based Polymer with Superior Multifunctionality for Boosting Cancer Phototheranostics DOI
Xue Meng, Yingnan Xu, Yuan Zhang

et al.

ACS Materials Letters, Journal Year: 2025, Volume and Issue: unknown, P. 1431 - 1439

Published: March 19, 2025

Molecular agents with exceptional multifunctionality are highly sought for phototheranostic applications. Herein we present a high-performance polymer near-infrared II (NIR-II) fluorescence and photoacoustic (PA) imaging-guided mild photothermal therapy (mPTT) of tumors. We synthesize series semiconducting polymers based on pyrrolopyrrole cyanine, identifying that P(P-T) exhibits large mass extinction coefficient (139 L g–1 cm–1), excellent performance, bright NIR-II fluorescence, PA imaging signals, making it among the highest-performing in these properties. A tumor-targeting agent was developed by coencapsulating heat shock protein (HSP) inhibitor camouflaging M1 macrophage membranes. The integration enables comprehensive tumor site delineation, guiding subsequent therapeutic intervention. In 4T1 tumor-bearing mice, synergistic effect mPTT under low-power 808 nm laser irradiation, combined HSP inhibition, resulted significant suppression. This work offers valuable insights designing advanced agents.

Language: Английский

Citations

0
Advancements in the Application of the Intersection of Medicine and Engineering in Cancer Research DOI Creative Commons
Haitao Chen,

Guan-Meng Zhang,

Yuping Qian

et al.

Published: April 7, 2025

ABSTRACT Cancer research predominantly centers on diagnosis, treatment, and elucidation of underlying mechanisms. Nevertheless, the intricate nature tumor genesis development has rendered early diagnostic therapeutic outcomes less than optimal, making conquest a formidable challenge. The interdisciplinary fusion medicine engineering, termed “intersection engineering”, emerged as groundbreaking paradigm, offering novel avenues for advancing cancer studies. As this approach evolves, it yielded numerous breakthroughs in mechanistic exploration. In review, we summarize how intersection engineering propels progress by leveraging combined strengths medicine, bioinformatics, materials science, artificial intelligence. This addresses limitations traditional diagnostics therapies, such low sensitivity, poor efficacy, significant side effects, challenges associated with Moreover, highlight global cutting‐edge advancements potential future directions field.

Language: Английский

Citations

0
Organic NIR‐II Nanofluorophore with Ultrahigh Quantum Yield for Vessels Imaging and Fluorescence Image‐Guided Surgery DOI
Xinyi Zhang, Ling Li, Yuxin Ren

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 7, 2024

Abstract The second near‐infrared window (NIR‐II) fluorescence imaging has aroused more and interest in biomedical applications due to negligible autofluorescence deep penetration ability. However, the quantum yield of NIR‐II fluorophores with than 1100 nm emission wavelength is typically less 1%, thus limiting quality tissues. In this study, a novel organic small molecule CTB1125 designed synthesized. Due an efficient intramolecular charge transfer (ICT) facilitated by high donor‐acceptor‐donor (D‐A‐D) strength structure, exhibits maximum 1125 nm. Additionally, branched alkyl chains are modified on conjugated fused ring backbone reduce intermolecular stacking. encapsulated amphiphilic copolymer PS 2000 ‐PEG form CTB1125‐NPs, which exhibit ultrahigh up 4.84% aqueous solution, excellent photostability, signal‐to‐noise rate. these outstanding properties, CTB1125‐NPs have been successfully used for clear long‐duration vessel amounts low laser power short exposure time, precisely guiding surgical resection tumors mice through imaging. This work provides promising fluorophore brightness deep‐tissue imaging‐guided surgery.

Language: Английский

Citations

0