Understanding the ecological impacts of nanoparticles: risks, monitoring, and mitigation strategies

Nanotechnology for Environmental Engineering, Journal Year: 2025, Volume and Issue: 10(1)

Published: Jan. 13, 2025

Language: Английский

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Enhancing RNA-lipid nanoparticle delivery: Organ- and cell-specificity and barcoding strategies

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 375, P. 366 - 388

Published: Sept. 18, 2024

Recent advancements in RNA therapeutics highlight the critical need for precision gene delivery systems that target specific organs and cells. Lipid nanoparticles (LNPs) have emerged as key vectors delivering mRNA siRNA, offering protection against enzymatic degradation, enabling targeted cellular uptake, facilitating cargo release into cytosol. This review discusses development optimization of organ- cell-specific LNPs, focusing on their design, mechanisms action, therapeutic applications. We explore innovations such DNA/RNA barcoding, which facilitates high-throughput screening precise adjustments formulations. address major challenges, including improving endosomal escape, minimizing off-target effects, enhancing efficiencies. Notable clinical trials recent FDA approvals illustrate practical applications future potential LNP-based therapies. Our findings suggest while considerable progress has been made, continued research is essential to resolve existing limitations bridge gap between pre-clinical evaluation safety efficacy therapeutics. highlights dynamic LNP research. It outlines a roadmap RNA-based medicine.

Language: Английский

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A General Strategy for Exceptionally Robust Conducting Polymer‐Based Bioelectrodes with Multimodal Capabilities Through Decoupled Charge Transport Mechanisms

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 12, 2025

Abstract Bioelectrodes function as a critical interface for signal transduction between living organisms and electronics. Conducting polymers (CPs), particularly poly(3,4‐ethylenedioxythiophene):poly(styrenesulfonate), are among the most promising materials bioelectrodes, due to their electrical performance, high compactness, ease of processing, but often suffer from degradation or de‐doping even in some common environments (e.g., stimulation, chemicals, temperatures). This instability therefore severely undermines reliability practical application. To resolve this issue, novel strategy separating electron transfer electron‐ion is proposed. Specifically, chemically derived holey graphene (HG), serving an ultra‐stable mixed ion‐electron conductor, introduced into CP matrix. The HG can restore CP's destructed conductive pathways, whilst its porosity intercalation by synergically preserve fast ionic molecular diffusion. resulting bioelectrode exhibits excellent low impedance, charge injection capacity, electrochemical activity, outstanding resilience various harsh conditions, outperforming HG, reduced oxide, CP, graphene‐coated electrodes. Furthermore, also broad compatibility with processing techniques proves adaptable other electrode systems, such stretchable electrodes, paving way applications electrophysical capture, neuron modulation, biochemical analysis.

Language: Английский

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Application of nanomedicines in tumor immunotherapy

Journal of Molecular Cell Biology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 27, 2024

Abstract Tumor immunotherapy has emerged as a formidable strategy, demonstrating substantial achievements in the field of cancer treatment. Despite its remarkable success, intrinsic limitations such insufficient targeting capabilities, side effects, and resistance to hinder efficacy. To address these challenges, utilization nanomedicines tumor been broadly explored, capitalizing on their advantages delivery capability, loading capacity, modifiability, biocompatibility. Through rational design approaches, are engineered meet diverse requirements synergize with different regimens maximize therapeutic efficacy while alleviating effects. This review initially discusses challenges associated underscores pivotal role played by overcoming obstacles. Subsequently, representative types nanoparticles systematically introduced based structural properties, advantages, potential limitations, future research directions. Special emphasis is placed recent advancements range designed for specific strategies. Finally, clinical applications well prospects discussed.

Language: Английский

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