Piezo1-related physiological and pathological processes in glioblastoma DOI Creative Commons
Weijia Fu,

Xue Hou,

Lijuan Ding

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 21, 2025

Glioblastoma (GBM) is the most malignant of astrocytomas, primarily involving cerebral hemispheres and cortex. It one fatal refractory solid tumors with a 5-year survival rate only 5% in adults. Cells biological tissues are subjected to mechanical forces, including hydrostatic pressure, shear stress, compression tension. can convert mechanomechanical signals into or electrical signals, process known as signaling. Piezo1 channels, members Piezo family mechanosensitive ion be directly activated by stimuli alone, mediating cation currents that activate subsequent signaling pathways. Studies have shown largely unexpressed normal brain but expressed at high levels glioblastoma significantly contribute development progression, its role pathogenesis remains unclear. We reviewed relevant literature data six major databases PubMed, EMBASE, CINAHL, Scopus, Web Science TCGA. Finally, total 126 papers were selected for review analysis (Search terms include: glioblastoma, piezo1, biomechanical, targeted therapy, mechanomechanical, extracellular matrix, radiation therapy more). The piezo1 was summarized. affects several fundamental pathophysiological processes such tissue sclerosis, angiogenesis, energy supply, immune cell infiltration, used an indicator malignancy prognosis patients well therapeutic target control tumor progression. pathological mechanism very complex, aberrant expression plays important glioblastoma. Specific mechanistic studies focusing on will help us understand mechanobiology develop new approaches patients.

Language: Английский

Applying Ultrasound to Mechanically and Noninvasively Sensitize Prostate Tumors to TRAIL‐Mediated Apoptosis DOI Creative Commons

Abigail R. Fabiano,

Malachy Newman,

Jenna A. Dombroski

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 20, 2025

Abstract Non‐surgical and safe prostate cancer (PCa) therapies are in demand. Soluble tumor necrosis factor (TNF‐α) related apoptosis inducing ligand (TRAIL), a cancer‐specific drug, shows preclinical efficacy but has short circulation half‐life. This research shown that physiological fluid shear stress activates mechanosensitive ion channels (MSCs), such as Piezo1, enhancing TRAIL‐mediated cells. Herein, noninvasive, focal ultrasound (FUS) is implemented to augment the pro‐apoptotic effects of TRAIL. Using thermally FUS parameters, it observed TRAIL sensitivity increases with higher pressure PCa cells, mediated by Piezo1. confirmed examining calcium chelation, MSC inhibitors, PIEZO knockdown. In vivo, multi‐dose study 10 min exposure 0 4‐h intervals between significantly reduce burden, an increase evident enhanced cleaved‐caspase 3 expression. mechanotherapy offers clinically translatable approach utilizing widely available technology, applicable treat additional types.

Language: Английский

Citations

0
Piezo1-related physiological and pathological processes in glioblastoma DOI Creative Commons
Weijia Fu,

Xue Hou,

Lijuan Ding

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 21, 2025

Glioblastoma (GBM) is the most malignant of astrocytomas, primarily involving cerebral hemispheres and cortex. It one fatal refractory solid tumors with a 5-year survival rate only 5% in adults. Cells biological tissues are subjected to mechanical forces, including hydrostatic pressure, shear stress, compression tension. can convert mechanomechanical signals into or electrical signals, process known as signaling. Piezo1 channels, members Piezo family mechanosensitive ion be directly activated by stimuli alone, mediating cation currents that activate subsequent signaling pathways. Studies have shown largely unexpressed normal brain but expressed at high levels glioblastoma significantly contribute development progression, its role pathogenesis remains unclear. We reviewed relevant literature data six major databases PubMed, EMBASE, CINAHL, Scopus, Web Science TCGA. Finally, total 126 papers were selected for review analysis (Search terms include: glioblastoma, piezo1, biomechanical, targeted therapy, mechanomechanical, extracellular matrix, radiation therapy more). The piezo1 was summarized. affects several fundamental pathophysiological processes such tissue sclerosis, angiogenesis, energy supply, immune cell infiltration, used an indicator malignancy prognosis patients well therapeutic target control tumor progression. pathological mechanism very complex, aberrant expression plays important glioblastoma. Specific mechanistic studies focusing on will help us understand mechanobiology develop new approaches patients.

Language: Английский

Citations

0