Multiscale Structural Analysis of Aggregation-Induced Emission Nanocrystals by Combining Electron and Confocal Microscopy DOI
Shitao Wu, Jianyu Zhang, Jing Zhang

et al.

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Aggregation-induced emission (AIE) materials have attracted intense interest due to their remarkable luminescent properties and potential applications in biological medical fields. A comprehensive structural analysis from atomic-level micrometer-scale is essential for rationally designing AIE understanding structure-property relationships. However, this remains a challenge the lack of proper methods. Herein, we present strategy multiscale through combination electron confocal microscopy. One mechanically induced fluorescent material consisting chiral Au(I) complex was prepared studied. The correlation scanning optical microscope images reveals that fluorescence closely related anisotropy nanocrystals with strong signals on fracture {110} facets. Furthermore, instead growing large single crystals, crystal structures individual were directly resolved using three-dimensional diffraction (3D ED), highlighting changes molecular arrangement before after mechanical treatment. results provide experimental evidence previously proposed Restriction Intramolecular Rotation (RIR) mechanism.

Language: Английский

Aggregation-induced enhanced emission (AIEE), pH sensing and selective detection of sulfuric acid of novel imidazole-based surrogates made via microwave-assisted synthesis DOI Creative Commons

Noorullah Baig,

Suchetha Shetty,

Anuvasita Parikh

et al.

RSC Advances, Journal Year: 2025, Volume and Issue: 15(8), P. 5932 - 5941

Published: Jan. 1, 2025

Novel imidazole derivatives were made exhibiting Aggregation Induced Enhanced Emission with strong luminescence (435–453 nm). The compounds also disclosed pH sensing properties, especially towards sulfuric acid at concentrations as of 16.5 μM.

Language: Английский

Citations

0
Targeted High‐Resolution 3D Imaging of Tumor Vasculatures at Different Stages Using Far‐Red AIE Nanoparticles Compatible with Tissue Clearing DOI

Xiao‐Ting Gong,

Xianyin Dai, Wei Cheng

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

Abstract The occurrence and progression of blood vessels plays a pivotal role in different stages tumor development, while current imaging techniques exhibit limited sensitivity to capture the dynamic changes vasculature at stages. This drawback hinders comprehensive understanding microenvironment, thereby impeding development efficacious therapeutic strategies. Herein, high‐resolution three‐dimensional (3D) technology is developed for mapping analyzing vasculatures using HA@TANP, supramolecular assembly far‐red fluorescence nanoparticles with aggregation‐induced emission (AIE), compatible tissue clearing. hyaluronic acid (HA) HA@TANP specifically targets CD44 antigen vasculature, acrylic applied temperature‐induced polymerization ensure covalent attachment AIE fluorophores. Additionally, optical clearing boosts light penetration resolution dense tissues. strategy allows quantitative analyses vascular diameter, length, straightness their correlation various responses treatments. findings contribute more distinct stages, providing valuable insights enhanced cancer diagnosis therapies from vascular‐targeted perspective.

Language: Английский

Citations

0
Reprogrammed glycolysis-induced augmentation of NIR-II excited photodynamic/photothermal therapy DOI
Chunbai Xiang, Qihang Ding, Ting Jiang

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: 320, P. 123235 - 123235

Published: March 4, 2025

Language: Английский

Citations

0
Conjugated Microporous Polymer Containing Pyrene and Dibenzo[g,p]chrysene Moieties as A Luminescent Powerhouse for Multi-Target Sensing and Environmental Safety DOI

Mohamed Gamal Mohamed,

Abdul Basit, Manivannan Madhu

et al.

Microporous and Mesoporous Materials, Journal Year: 2025, Volume and Issue: unknown, P. 113620 - 113620

Published: March 1, 2025

Language: Английский

Citations

0
Multiscale Structural Analysis of Aggregation-Induced Emission Nanocrystals by Combining Electron and Confocal Microscopy DOI
Shitao Wu, Jianyu Zhang, Jing Zhang

et al.

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Aggregation-induced emission (AIE) materials have attracted intense interest due to their remarkable luminescent properties and potential applications in biological medical fields. A comprehensive structural analysis from atomic-level micrometer-scale is essential for rationally designing AIE understanding structure-property relationships. However, this remains a challenge the lack of proper methods. Herein, we present strategy multiscale through combination electron confocal microscopy. One mechanically induced fluorescent material consisting chiral Au(I) complex was prepared studied. The correlation scanning optical microscope images reveals that fluorescence closely related anisotropy nanocrystals with strong signals on fracture {110} facets. Furthermore, instead growing large single crystals, crystal structures individual were directly resolved using three-dimensional diffraction (3D ED), highlighting changes molecular arrangement before after mechanical treatment. results provide experimental evidence previously proposed Restriction Intramolecular Rotation (RIR) mechanism.

Language: Английский

Citations

0