Engineered Nanozymes with Asymmetric Mn─O─Ce Sites for Intratumorally Leveraged Multimode Therapy DOI

Ye Jin,

Chunsheng Li, Jiating Xu

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 9, 2025

Abstract Due to the enhanced flexibility of catalytic sites and synergistic effects between dual‐atom active centers, nanozymes stand out in tumor therapy. However, precisely regulating d‐band centers diatomic break linear‐scaling relationship intermediates remains a challenge. Herein, hydrothermally mass‐produced oxygen vacancies‐engineered bimetallic silicate bio‐nanoplatform with highly asymmetric O‐bridged cerium─manganese (Ce─Mn) (CeMn‐V DAs/EGCG@HA) is meticulously constructed by loading epigallocatechin‐3‐gallate (EGCG) modifying hyaluronic acid (HA) for multimodal cancer Theoretical calculations reveal that introduction Ce serves as secondary upshifts center Mn sites, thereby optimizing adsorption/desorption intermediates. The Mn─O─Ce moiety facilitates electron transport within CeMn‐V DAs, significantly enhancing peroxidase‐like activities ( K m = 27.7 mM V max 3.21×10 ─7 M s ─1 ). Upon 650 nm laser irradiation, DAs/EGCG inhibits heat shock protein expression, enabling mild‐photothermal η 36.1%) therapy, which can productively inhibit growth vivo, an inhibition rate up 96.2%. ligand‐field effect EGCG‐Mn/Ce complexes, high‐valent metal ions are effectively reduced, sustaining intrinsic self‐driven cocatalytic cycle reaction. Overall, construction bridged will further promote deep integration nanotechnology biology.

Language: Английский

Nanomaterials Enhanced Sonodynamic Therapy for Multiple Tumor Treatment DOI Creative Commons
Mengyao Yang, Xin Wang,

Mengke Peng

et al.

Nano-Micro Letters, Journal Year: 2025, Volume and Issue: 17(1)

Published: Feb. 24, 2025

Abstract Sonodynamic therapy (SDT) as an emerging modality for malignant tumors mainly involves in sonosensitizers and low-intensity ultrasound (US), which can safely penetrate the tissue without significant attenuation. SDT not only has advantages including high precision, non-invasiveness, minimal side effects, but also overcomes limitation of low penetration light to deep tumors. The cytotoxic reactive oxygen species be produced by utilization combined with US kill tumor cells. However, underlying mechanism been elucidated, its unsatisfactory efficiency retards further clinical application. Herein, we shed on main mechanisms types sonosensitizers, organic inorganic sonosensitizers. Due development nanotechnology, many novel nanoplatforms are utilized this arisen field solve barriers enable continuous innovation. This review highlights potential nanosonosensitizers focus enhanced based monotherapy or synergistic that difficult reach traditional treatment, especially orthotopic cancers.

Language: Английский

Citations

4
Sustained modulation of tumor microenvironment via sorafenib-loaded mesoporous ferromanganese nanozymes for enhanced apoptosis-ferroptosis cancer therapy DOI
Guanghui Lin,

Jieyao Chen,

Xiaojia Liu

et al.

Chinese Chemical Letters, Journal Year: 2025, Volume and Issue: unknown, P. 111018 - 111018

Published: Feb. 1, 2025

Language: Английский

Citations

0
Light-Responsive Ru–Se Coordinated Nanoreactor Spatiotemporally Relieves Hypoxia for Photodynamic Therapy of Bladder Cancer DOI
Wenrui Ouyang, Heng Wang, Zhijian Zhao

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: May 9, 2025

Photodynamic therapy (PDT) has been employed as a noninvasive treatment option for bladder cancer due to its controllability and minimal toxicity. However, the efficacy of PDT is often compromised by hypoxic microenvironment solid tumors. To address this challenge, our research dedicated developing Ru-Se-Ce6 nanoreactor that combines photoresponsiveness Ru-Se coordination bonds reactive oxygen species (ROS) triggered diselenide bonds, achieving dual-controlled release photosensitizer enhance effectiveness. The photoresponsive catalytic characteristics were validated through synchrotron radiation density functional theory calculations. Under laser irradiation, metal-to-ligand charge transfer (MLCT) within ruthenium complex leads cleavage bond, resulting in liberation complex, which significantly improves O2 generation from H2O2 tumor (TME). In vivo assessments demonstrated disrupted mitochondrial membrane potential via excessive ROS production, leading cell cycle arrest apoptosis. Additionally, revealed significant suppression subcutaneous orthotopic models while exhibiting good biocompatibility. These findings propose potent innovative approach therapy.

Language: Английский

Citations

0
Engineered Nanozymes with Asymmetric Mn─O─Ce Sites for Intratumorally Leveraged Multimode Therapy DOI

Ye Jin,

Chunsheng Li, Jiating Xu

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 9, 2025

Abstract Due to the enhanced flexibility of catalytic sites and synergistic effects between dual‐atom active centers, nanozymes stand out in tumor therapy. However, precisely regulating d‐band centers diatomic break linear‐scaling relationship intermediates remains a challenge. Herein, hydrothermally mass‐produced oxygen vacancies‐engineered bimetallic silicate bio‐nanoplatform with highly asymmetric O‐bridged cerium─manganese (Ce─Mn) (CeMn‐V DAs/EGCG@HA) is meticulously constructed by loading epigallocatechin‐3‐gallate (EGCG) modifying hyaluronic acid (HA) for multimodal cancer Theoretical calculations reveal that introduction Ce serves as secondary upshifts center Mn sites, thereby optimizing adsorption/desorption intermediates. The Mn─O─Ce moiety facilitates electron transport within CeMn‐V DAs, significantly enhancing peroxidase‐like activities ( K m = 27.7 mM V max 3.21×10 ─7 M s ─1 ). Upon 650 nm laser irradiation, DAs/EGCG inhibits heat shock protein expression, enabling mild‐photothermal η 36.1%) therapy, which can productively inhibit growth vivo, an inhibition rate up 96.2%. ligand‐field effect EGCG‐Mn/Ce complexes, high‐valent metal ions are effectively reduced, sustaining intrinsic self‐driven cocatalytic cycle reaction. Overall, construction bridged will further promote deep integration nanotechnology biology.

Language: Английский

Citations

0