The roles of cancer stem cells and therapeutic implications in melanoma DOI Creative Commons

Xiaoli Mu,

Yixin Zhou, Yongxin Yu

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 14, 2024

Melanoma is a highly malignant skin tumor characterized by high metastasis and poor prognosis. Recent studies have highlighted the pivotal role of melanoma stem cells (MSCs)-a subpopulation cancer (CSCs)-in driving growth, metastasis, therapeutic resistance, recurrence. Similar to CSCs in other cancers, MSCs possess unique characteristics, including specific surface markers, dysregulated signaling pathways, ability thrive within complex microenvironment (TME). This review explored current landscape MSC research, discussing identification MSC-specific key pathways such as Wnt/β-catenin, Notch, Hedgehog (Hh), how interactions TME, hypoxia immune cells, contribute MSC-mediated drug resistance metastatic behavior. Furthermore, we also investigated latest strategies targeting MSCs, small-molecule inhibitors, immune-based approaches, novel vaccine developments, with an emphasis on their potential overcome progression improve clinical outcomes. aims provide valuable insights into roles biology offers perspectives for future research advances against this challenging disease.

Language: Английский

The uptake of extracellular vesicles: research progress in cancer drug resistance and beyond DOI

Luomeng Qian,

Pangzhou Chen,

Shiwu Zhang

et al.

Drug Resistance Updates, Journal Year: 2025, Volume and Issue: 79, P. 101209 - 101209

Published: Feb. 1, 2025

Language: Английский

Citations

1
Tumour-derived exosomal miR-205 promotes ovarian cancer cell progression through M2 macrophage polarization via the PI3K/Akt/mTOR pathway DOI Creative Commons
Liuqing He, Quan Chen, Xiaoying Wu

et al.

Journal of Ovarian Research, Journal Year: 2025, Volume and Issue: 18(1)

Published: Feb. 15, 2025

Tumour-associated macrophages (TAMs) are the most abundant immune cells in tumour environment and considered similar to M2 macrophages, which facilitate cancer progression. Exosomes, as important mediators of cross-talk between tumour-associated can development metastasis ovarian by mediating macrophage polarization. However, exact mechanisms underlying communication (OC) during OC progression remain unclear. Here, we demonstrated that high expression miR-205 was associated with infiltration, affected prognosis patients. Importantly, tumour-derived could be transported from via exosomes promote cell invasion inducing M2-like Animal experiments further confirmed exosomal miR-205-induced accelerated vivo. Mechanistically, downregulated PTEN, activating PI3K/AKT/mTOR signalling pathway, is critical for These results reveal plays a pivotal role polarization within microenvironment, highlighting its potential therapeutic target treatment. This study not only enhances our understanding interactions but also opens new avenues targeted therapies against cancer.

Language: Английский

Citations

0
Exosomes as key mediators in immune and cancer cell interactions: insights in melanoma progression and therapy DOI
Chou‐Yi Hsu, Harish C. Chandramoorthy, Mohammed Sani Jaafaru

et al.

Archives of Dermatological Research, Journal Year: 2025, Volume and Issue: 317(1)

Published: April 19, 2025

Language: Английский

Citations

0
Tumor-derived exosomal miR-205 promotes ovarian cancer cell progression through M2 macrophage polarization via PI3K/Akt/mTOR pathway DOI Creative Commons
Liuqing He, Quan Chen, Xiaoying Wu

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 28, 2024

Abstract Background Tumour-associated macrophages (TAMs) are the most abundant immune cells in tumour environment and considered to be similar M2 macrophages, which facilitate cancer progression. Exosomes, as important mediators of cross-talk between tumor tumour-associated can development metastasis ovarian by mediates macrophage polarization. However, exact mechanisms underlying communication (OC) during progression remain unclear. Results Herein, we demonstrated that high expression miR-205 was associated with infiltration affected prognosis OC patients. Importantly, tumor-derived could transported from via exosomes promote cell invasion inducing M2-like polarisation. Animal experiments further confirmed exosomal-miR-205-induced accelerate vivo. Mechanistically, downregulates PTEN, activating PI3K/AKT/mTOR signaling pathway, is critical for Conclusions These results reveal exosomal plays a pivotal role polarization within microenvironment, highlighting its potential therapeutic target treatment. This study not only enhances our understanding interactions but also opens new avenues targeted therapies against cancer.

Language: Английский

Citations

0
The roles of cancer stem cells and therapeutic implications in melanoma DOI Creative Commons

Xiaoli Mu,

Yixin Zhou, Yongxin Yu

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 14, 2024

Melanoma is a highly malignant skin tumor characterized by high metastasis and poor prognosis. Recent studies have highlighted the pivotal role of melanoma stem cells (MSCs)-a subpopulation cancer (CSCs)-in driving growth, metastasis, therapeutic resistance, recurrence. Similar to CSCs in other cancers, MSCs possess unique characteristics, including specific surface markers, dysregulated signaling pathways, ability thrive within complex microenvironment (TME). This review explored current landscape MSC research, discussing identification MSC-specific key pathways such as Wnt/β-catenin, Notch, Hedgehog (Hh), how interactions TME, hypoxia immune cells, contribute MSC-mediated drug resistance metastatic behavior. Furthermore, we also investigated latest strategies targeting MSCs, small-molecule inhibitors, immune-based approaches, novel vaccine developments, with an emphasis on their potential overcome progression improve clinical outcomes. aims provide valuable insights into roles biology offers perspectives for future research advances against this challenging disease.

Language: Английский

Citations

0