Nitric Oxide-Producing Multiple Functional Nanoparticle Remodeling Tumor Microenvironment for Synergistic Photodynamic Immunotherapy against Hypoxic Tumor

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

The treatment of pancreatic cancer faces significant challenges due to connective tissue hyperplasia and severe hypoxia. Unlike oxygen-dependent Type II photosensitizers, I photosensitizers can produce a substantial amount reactive oxygen species, even under hypoxic conditions, making them more suitable for photodynamic therapy cancer. However, the dense extracellular matrix limits penetration efficiency presence immunosuppressive cells in tumor microenvironment reduces therapeutic effect. To address these challenges, we designed photoimmunotherapeutic M1@PAP nanoparticles composed photosensitizer anti-PD-L1 siRNA (siPD-L1), which was encapsulated into M1 macrophage membrane vesicles. In this system, pyropheophorbide-a (PPA) covalently conjugated poly-l-arginine (Arg9). Notably, it capable generating sufficient superoxide anions thereby functioning as photosensitizer. Furthermore, Arg9 acted nitric oxide (NO) donor, enhancing nanophotosensitizer by inhibiting cancer-associated fibroblast (CAF) activation decomposing matrix. Additionally, vesicles provided active targeting capabilities reeducated immunosuppressed M2 macrophages. reversal further promoted efficacy immunotherapy, showing great potential synergistic immunotherapy against tumor.

Language: Английский

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Novel Peptide-Modified Zeolitic Imidazolate Framework-8 Nanoparticles with pH-Sensitive Release of Doxorubicin for Targeted Treatment of Colorectal Cancer

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(2), P. 246 - 246

Published: Feb. 13, 2025

Background: Colorectal cancer (CRC) is one of the common malignant tumors. Chemotherapeutic agents represented by doxorubicin (DOX) are adjuvant therapies for patients with advanced CRC. However, DOX suffers from dose-dependent cardiotoxicity and myelosuppression due to a lack targeting specificity, which severely limits its clinical application. Methods: Herein, we constructed zeolitic imidazolate framework-8 (ZIF-8) modified novel peptide (LT peptide) deliver chemotherapeutic drug targeted treatment Results: In this study, LT-PEG@DOX@ZIF-8 nanoparticles were prepared simple method suitable particle size zeta potential, also capable pH-responsive release. vitro assays exhibited that effectively taken up C26 cells, significantly inhibited cell proliferation, induced apoptosis. Furthermore, in mice models colorectal tumors, displayed specific tumor aggregation exerted anti-tumor effects prolong survival mice. Conclusions: conclusion, provides promising strategy delivery treat

Language: Английский

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A magnetic nanoreactor with microenvironment regulation capability for targeted and enhanced tumor chemodynamic therapy

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161356 - 161356

Published: March 1, 2025

Language: Английский

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Prominent Supramolecular Systems for Cancer Therapy: From Structural Design to Tailored Applications

European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 117754 - 117754

Published: May 1, 2025

Language: Английский

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NIR‐II‐Responsive Chainmail Nanocatalysts for Spatiotemporally Controlled Enzymatic Tumor Therapy

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 20, 2025

Abstract The clinical translation of metal‐based peroxidase‐like nanozymes for antitumor therapy faces two critical challenges: off‐target catalytic activation and suboptimal hydroxyl radical (•OH) generation efficiency. To address these limitations, an innovative chainmail nanocatalyst featuring nitrogen‐doped carbon‐encapsulated nanoceria is developed, which combines spatial confinement effects with photo‐trigger enhancement. graphitic carbon shell serves as a physical barrier that effectively isolates metallic cerium from the biological environment, reducing nonspecific by 100% compared to bare nanoceria. Remarkably, under 1064 nm laser irradiation, electrons species can penetrate through quantum tunneling effects, activating multiple enzymatic pathways. Vacancy engineering further optimizes Ce 3+ /Ce 4+ redox pair ratio (1.75 vs 0.44 in pristine nanoceria), establishing electron reservoir facilitates amplification H 2 O ‐to‐•OH conversion glutathione oxidase‐mimicking activity tumor microenvironment remodeling. This dual mechanism synergistically elevates intracellular oxidative stress while preserving normal tissue viability. In vivo evaluations demonstrate photoactivated exhibits remarkable suppression efficacy, prolonging survival duration tumor‐bearing mice 33 days 70 days. light‐gated architecture provides paradigm spatiotemporally controlled therapy, resolving dilemma between potency specificity nanozyme design.

Language: Английский

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The Role of ROS in Atherosclerosis and ROS-Based Nanotherapeutics for Atherosclerosis: Atherosclerotic Lesion Targeting, ROS Scavenging, and ROS-Responsive Activity

ACS Omega, Journal Year: 2025, Volume and Issue: unknown

Published: May 23, 2025

Language: Английский

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Homologous-adhering/targeting cell membrane- and cell-mediated delivery systems: a cancer-catch-cancer strategy in cancer therapy

Regenerative Biomaterials, Journal Year: 2024, Volume and Issue: 12

Published: Nov. 20, 2024

Abstract Low tumor enrichment remains a serious and urgent problem for drug delivery in cancer therapy. Accurate targeting of sites is still critical aim Though there have been variety strategies to improve the enrichment, biological barriers cause most delivered guests fail or be excreted before they work. Recently, cell membrane-based systems attracted huge amount attention due their advantages such as easy access, good biocompatibility immune escape, which contribute biomimetic structures specific surface proteins. Furthermore, are referred homologous-targeting function exhibit significantly high adhesion internalization homologous-type cells even though exact mechanism not entirely revealed. Here, we summarize sources characterizations membrane systems, including reconstructed single hybrid nano-/microcarriers, well engineered cells. Additionally, advanced applications these therapy categorized summarized according components membranes. The potential factors related homologous also discussed. By discussing applications, challenges opportunities, expect far-reaching development preclinic clinics.

Language: Английский

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Hyaluronic acid-mediated targeted nano-modulators for activation of pyroptosis for cancer therapy through multichannel regulation of Ca2+ overload

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 299, P. 140116 - 140116

Published: Jan. 20, 2025

Language: Английский

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Hyperthermia-Accelerated Ion-Radical Production for Enhanced Tumor Nanocatalytic Therapy with Inhibition of Tumor Growth and Recurrence

Published: Jan. 1, 2025

Language: Английский

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Chemodynamic Therapy Enhanced ¹³¹I‐Radiotherapy for Efficient Inhibition on Cancer Growth and Metastasis

Small, Journal Year: 2025, Volume and Issue: unknown

Published: May 16, 2025

Abstract Iodine‐131 ( 131 I), a cornerstone of thyroid cancer therapy, suffers from limited efficacy in other cancers due to poor tumor accumulation and hypoxia‐driven radiotherapy resistance. To overcome these challenges, I‐M@HI, theranostic nanoparticle was engineered that synergizes with chemodynamic therapy (CDT). This platform integrated Mn(III) porphyrin indocyanine green self‐assembled on albumin, enabling dual‐mode fluorescence/MRI‐guided imaging, tumor/sentinel lymph node‐targeted accumulation, hypoxia modulation. The catalyzes intratumoral hydrogen peroxide into cytotoxic hydroxyl radicals for CDT while alleviating amplify I radiotherapy. In subcutaneous tumors, I‐M@HI achieved >85% inhibition by inducing immunogenic cell death, marked calreticulin exposure high mobility group box 1 release, triggered systemic anti‐tumor immunity. Strikingly, breast metastasis model, selectively eradicated sentinel node metastases, reducing lung metastatic nodules >90%, representing critical advancement preventing spread. work pioneers multifunctional nanoplatform not only enhances but also redefines precision inhibition, offering transformative strategy advanced therapy.

Language: Английский

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