Andrias davidianus Derived Glycosaminoglycans Direct Diabetic Wound Repair by Reprogramming Reparative Macrophage Glucolipid Metabolism

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

Abstract Harnessing cross‐species regenerative cues to direct human potential is increasingly recognized as an excellent strategy in medicine, particularly for addressing the challenges of impaired wound healing aging populations. The skin mucus Andrias davidianus plays a critical role self‐protection and tissue repair, yet fundamental factors mechanisms involved remain elusive. Here, this work presents evidence that glycosaminoglycans (GAGs) derived from secretion (SAGs) serve potent mediators angiogenesis inflammatory remodeling, facilitating efficient diabetic wounds. Mechanistic studies reveal SAGs promote macrophage polarization toward anti‐inflammatory pro‐regenerative phenotype (CD206 + /Arg1 ) via glucolipid metabolic reprogramming. This process suppresses excessive inflammation enhances expression VEGF IL‐10 create facilitative microenvironment regeneration. Additionally, develops SAGs‐GelMA composite microspheres address multiple stages healing, including rapid hemostasis, exudate control, activation endogenous processes. engineered approach significantly improves scarless wounds by recruitment reparative macrophages. findings offer new insights into highlight therapeutic application repair.

Language: Английский

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Revolutionizing Bone Repair and Regeneration: The Role of Machine Learning in Designing Advanced Nanocomposite Hydrogels

Polymers for Advanced Technologies, Journal Year: 2025, Volume and Issue: 36(4)

Published: March 28, 2025

ABSTRACT Bone repair is a complex biological process requiring dynamic interplay between cellular mechanisms, molecular signaling, and environmental factors. The intricate stages of bone healing, including hematoma formation, inflammation, soft callus development, hard remodeling, are driven by coordinated responses pathways. Proinflammatory cytokines, growth factors, the extracellular matrix play critical roles in promoting osteogenesis angiogenesis. Factors such as age, systemic health, mechanical stability significantly influence efficiency. To address limitations natural advancements regenerative medicine have introduced innovative materials like nanocomposite hydrogels, which mimic microenvironment enhance function. Semi‐interpenetrating network (semi‐IPN) hydrogels emerged promising tool for tissue engineering. Combining crosslinked non‐crosslinked polymers, these offer balance stability, functionality, controlled degradation. Semi‐IPN provide structural support, facilitate cell attachment, enable sustained release bioactive molecules. Their flexibility adaptability make them suitable encapsulating stem cells targeted regeneration. Moreover, nonsurgical surgical scaffold delivery methods, ranging from injectable to 3D‐printed magnetically guided scaffolds, expanded horizons strategies, reduced invasiveness, improved patient outcomes. This review explores dynamics role regeneration, advanced construction strategies semi‐IPN repair. By integrating polymer science, nanotechnology, bioengineering, represent transformative shift addressing defects, paving way therapeutic approaches medicine. With ongoing advancements, technologies hold significant potential improve effectiveness accessibility solutions.

Language: Английский

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Multifunctional nanofiber-based dressings in coordination with adipose-derived stem cells for accelerated burn wound healing

Materials & Design, Journal Year: 2025, Volume and Issue: unknown, P. 113929 - 113929

Published: April 1, 2025

Language: Английский

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Dissolvable Core–Shell Microneedle Patch for Biphasic Drug Delivery To Enhance Diabetic Wound Healing

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: April 18, 2025

Diabetic wounds constitute one of the most prevalent complications among diabetic patients, characterized by a low healing rate and high recurrence rate. These frequently result in ulceration, amputation, and, severe cases, life-threatening conditions. The difficulty wound patients is primarily attributed to invasion pathogenic bacteria, dysregulation inflammatory response, insufficient angiogenesis. In this study, we developed core-shell microneedle (MN) patch that delivers antimicrobial agents, anti-inflammatory angiogenic agents biphasic release mode for treatment healing. Tetracycline hydrochloride (TCH) drug-carrying nanoparticles (SIM-PLGA NPs) were coated inner layer tip respond early bacterial infection subsequently induce Metformin (Met) was loaded onto outer shell needle regulate response. MN (TCH/SIM-PLGA NPs/Met MN) inhibited promoted cell migration application TCH/SIM-PLGA constructed model reduced inflammation, induced angiogenesis, encouraged collagen deposition tissue regeneration during repair, accelerated closure. This system, combined with MN, exhibits significant potential broader applications

Language: Английский

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Recent Advances in Handheld and Robotic Bioprinting Approach for Tissue Engineering

Advanced Materials Technologies, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Abstract 3D bioprinting has emerged as a transformative technology in tissue engineering, significantly impacting the creation of patient‐specific tissues to enhance clinical outcomes. Despite its rapid advancement, translating this from bench bedside remains critical need. New approaches, such handheld printers or robotic arm‐driven situ biofabrication techniques, have promising alternatives. These advancements enable reconstruction damaged directly on living anatomical structures, offering adaptability and precise matching affected area. The integration biomaterials, engineering principles, digital technologies, particularly robotics, garnered substantial interest both academic industrial sectors, highlighting potential for applications. However, challenges persist, including refining bioink formulations, adjusting mechanical properties, facilitating crosslinking, accurately mimicking extracellular matrix. This review explores cutting‐edge frontier regeneration, utilizing arm‐assisted printers. It systematically examines relative advantages, disadvantages, challenges, prospects it transitions side bed side.

Language: Английский

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3D‐Printed Microfluidic Platform for Creating Porous Nanofibrous Microspheres to Regulate Cell Response and Enhance Tissue Regeneration

Small, Journal Year: 2025, Volume and Issue: unknown

Published: May 2, 2025

Abstract Porous nanofibrous microspheres (PNMs) present a versatile and minimally invasive strategy for tissue regeneration, combining biomimetic morphology, tunable structure, injectability. While self‐assembly co‐axial electrospray are explored PNM fabrication, these methods limited in compositional versatility production scalability. Here, 3D‐printed microfluidic platform is presented that enables large‐scale fabrication of PNMs with precise control over size, pore architecture, morphology. can be functionalized bioactive molecules through UV crosslinking, enhancing their regenerative potential by promoting osteogenesis human bone marrow stromal cells (hBMSCs), angiogenesis umbilical vein endothelial (HUVECs), exerting anti‐inflammatory effects on macrophages. Subcutaneous implantation rats demonstrates support cell infiltration, minimize fibrosis, facilitate integration, achieving complete penetration incorporation within 14 days. These findings establish as versatile, scalable, customizable platforms, ideal applications injectable drugs or carriers, well powders, offering promising solutions wound healing regeneration.

Language: Английский

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Smart Polymer Microspheres: Preparation, Microstructures, Stimuli-Responsive Properties, and Applications

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: May 7, 2025

Smart polymer microspheres (SPMs) are a class of stimulus-responsive materials that undergo physical, chemical, or property changes in response to external stimuli, such as temperature, pH, light, and magnetic fields. In recent years, their diverse responsiveness tunable structures have enabled broad applications biomedicine, environmental protection, information encryption, other This study provides detailed review preparation methods SPMs, focusing on physical emulsification-solvent evaporation, microfluidics, electrostatic spraying well chemical approaches emulsion precipitation polymerization. Meanwhile, different types behaviors, temperature-, pH-, light-, magnetic-responsiveness, thoroughly examined. also explores the SPMs drug delivery, tissue engineering, monitoring, while discussing future technological challenges development directions this field.

Language: Английский

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