Dual Pathways of Photorelease Carbon Monoxide via Photosensitization for Tumor Treatment

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

Carbon monoxide (CO) gas therapy, as an emerging therapeutic strategy, is promising in tumor treatment. However, the development of a red or near-infrared light-driven efficient CO release strategy still challenging due to limited physicochemical characteristics photoactivated carbon monoxide-releasing molecules (photoCORMs). Here, we discovered novel photorelease mechanism that involved dual pathways via photosensitization. Specifically, photosensitizer Chlorin e6 (Ce6) sensitized oxygen produce singlet (1O2) and oxidized photoCORM Mn2(CO)10 air-saturated solvent under light (655 nm, 50 mW/cm2) irradiation. Furthermore, Ce6 could undergo multistep photochemical reactions CO, well degradation oxygen-depleted solution. As proof concept, demonstrated feasibility inhibition this both vitro vivo. These results provide robust platform for new approaches CO-mediated modulation signaling further facilitate practical use methods therapy

Language: Английский

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A CYP2J2‐Activated Photosensitizer with In Situ Enzyme Anchoring Induces Pyroptosis in Cancer Therapy

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 6, 2025

Abstract In photodynamic therapy, traditional photosensitizers exhibit limited tumor retention and targeting efficiency, posing significant challenges to achieving precision efficacy. this study, a photosensitizer is developed based on hemicyanine dye, known as Icy‐P, which features cationic structure that naturally targets mitochondria. Icy‐P contains CYP2J2 recognition receptors at its active sites, enabling precise of cells. Positioning ethyl carbamate adjacent the group initiates cascade reaction upon recognition, resulting in formation quinone intermediate, undergoes 1,4‐addition reaction. This facilitates binding an enzyme, leading prolonged time. The vivo residence time within cells ranges between 48 h 7 d. Furthermore, generates reactive oxygen species light exposure, mitochondrial damage, caspase‐1 activation, gasdermin D cleavage. These events ultimately induce pyroptosis, thereby enhancing efficacy cancer therapy.

Language: Английский

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Hydrogen sulfide-responsive and depleting NIR-II nanoplatform synergistic photodynamic therapy for colorectal cancer

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161711 - 161711

Published: March 1, 2025

Language: Английский

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Therapeutic application of nanosystems-based metalloptosis for enhanced tumor radiotherapy

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 536, P. 216666 - 216666

Published: April 10, 2025

Language: Английский

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