Obesity: pathophysiology and therapeutic interventions DOI Creative Commons
Yue Kong, Hong Seuk Yang, Rong Nie

et al.

Molecular Biomedicine, Journal Year: 2025, Volume and Issue: 6(1)

Published: April 25, 2025

Abstract Over the past few decades, obesity has transitioned from a localized health concern to pressing global public crisis affecting over 650 million adults globally, as documented by WHO epidemiological surveys. As chronic metabolic disorder characterized pathological adipose tissue expansion, inflammation, and neuroendocrine dysregulation that disrupts systemic homeostasis impairs physiological functions, is rarely an isolated condition; rather, it frequently complicated severe comorbidities collectively elevate mortality risks. Despite advances in nutritional science initiatives, sustained weight management success rates prevention remain limited, underscoring its recognition multifactorial disease influenced genetic, environmental, behavioral determinants. Notably, escalating prevalence of earlier onset younger populations have intensified urgency develop novel therapeutic agents simultaneously ensure efficacy safety. This review aims elucidate pathophysiological mechanisms underlying obesity, analyze major complications—including type 2 diabetes mellitus (T2DM), cardiovascular diseases (CVD), non-alcoholic fatty liver (NAFLD), obesity-related respiratory disorders, nephropathy (ORN), musculoskeletal impairments, malignancies, psychological comorbidities—and critically evaluate current anti-obesity strategies. Particular emphasis placed on emerging pharmacological interventions, exemplified plant-derived natural compounds such berberine (BBR), with focus their molecular mechanisms, clinical efficacy, advantages. By integrating mechanistic insights evidence, this seeks provide innovative perspectives for developing safe, accessible, effective treatments.

Language: Английский

Hawthorn carbon dots: a novel therapeutic agent for modulating body weight and hepatic lipid profiles in high-fat diet-fed mice DOI
Shuai Lin, Y. H. Zheng, Yi Xu

et al.

Nanoscale, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Synthesis of HCD (A) and intervention on obesity in high-fat diet mice (B).

Language: Английский

Citations

0
The multifaceted roles of macrophages in the transition from hepatitis to hepatocellular carcinoma: From mechanisms to therapeutic strategies DOI
Shuairan Zhang, Dong Hang,

Xiuli Jin

et al.

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2025, Volume and Issue: 1871(3), P. 167676 - 167676

Published: Jan. 18, 2025

Language: Английский

Citations

0
Engineering microcapsules with immune modulatory properties: Applications in cancer, inflammation, and autoimmunity DOI

Xin Tan,

Renwang Sheng, Liqin Ge

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161208 - 161208

Published: March 1, 2025

Language: Английский

Citations

0
SynBioNanoDesign: pioneering targeted drug delivery with engineered nanomaterials DOI Creative Commons
Qian Cai, Rui Guo, Dafu Chen

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 6, 2025

Synthetic biology and nanotechnology fusion represent a transformative approach promoting fundamental clinical biomedical science development. In SynBioNanoDesign, biological systems are reimagined as dynamic programmable materials to yield engineered nanomaterials with emerging specific functionalities. This review elucidates comprehensive examination of synthetic biology's pivotal role in advancing for targeted drug delivery systems. It begins exploring the synergy between nanotechnology, then highlights current landscape applications. Subsequently, discusses design novel informed by principles, focusing on expounding tools potential developing advanced nanomaterials. Afterward, research advances innovative through were systematically summarized, emphasizing integration genetic circuitry program nanomaterial responses. Furthermore, challenges, weaknesses opportunities, prospective directions, ethical societal implications SynBioNanoDesign elucidated. Finally, summarizes impact that may have drug-delivery technologies future.

Language: Английский

Citations

0
Revolutionizing Bone Repair and Regeneration: The Role of Machine Learning in Designing Advanced Nanocomposite Hydrogels DOI Open Access
Ashkan Farazin,

Amirhossein Gheisizadeh

Polymers for Advanced Technologies, Journal Year: 2025, Volume and Issue: 36(4)

Published: March 28, 2025

ABSTRACT Bone repair is a complex biological process requiring dynamic interplay between cellular mechanisms, molecular signaling, and environmental factors. The intricate stages of bone healing, including hematoma formation, inflammation, soft callus development, hard remodeling, are driven by coordinated responses pathways. Proinflammatory cytokines, growth factors, the extracellular matrix play critical roles in promoting osteogenesis angiogenesis. Factors such as age, systemic health, mechanical stability significantly influence efficiency. To address limitations natural advancements regenerative medicine have introduced innovative materials like nanocomposite hydrogels, which mimic microenvironment enhance function. Semi‐interpenetrating network (semi‐IPN) hydrogels emerged promising tool for tissue engineering. Combining crosslinked non‐crosslinked polymers, these offer balance stability, functionality, controlled degradation. Semi‐IPN provide structural support, facilitate cell attachment, enable sustained release bioactive molecules. Their flexibility adaptability make them suitable encapsulating stem cells targeted regeneration. Moreover, nonsurgical surgical scaffold delivery methods, ranging from injectable to 3D‐printed magnetically guided scaffolds, expanded horizons strategies, reduced invasiveness, improved patient outcomes. This review explores dynamics role regeneration, advanced construction strategies semi‐IPN repair. By integrating polymer science, nanotechnology, bioengineering, represent transformative shift addressing defects, paving way therapeutic approaches medicine. With ongoing advancements, technologies hold significant potential improve effectiveness accessibility solutions.

Language: Английский

Citations

0
Apigenin-loaded nanoparticles for obesity intervention through immunomodulation and adipocyte browning DOI
Neda Mohaghegh,

A. Iyer,

Ethan Wang

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113670 - 113670

Published: April 1, 2025

Language: Английский

Citations

0
Obesity: pathophysiology and therapeutic interventions DOI Creative Commons
Yue Kong, Hong Seuk Yang, Rong Nie

et al.

Molecular Biomedicine, Journal Year: 2025, Volume and Issue: 6(1)

Published: April 25, 2025

Abstract Over the past few decades, obesity has transitioned from a localized health concern to pressing global public crisis affecting over 650 million adults globally, as documented by WHO epidemiological surveys. As chronic metabolic disorder characterized pathological adipose tissue expansion, inflammation, and neuroendocrine dysregulation that disrupts systemic homeostasis impairs physiological functions, is rarely an isolated condition; rather, it frequently complicated severe comorbidities collectively elevate mortality risks. Despite advances in nutritional science initiatives, sustained weight management success rates prevention remain limited, underscoring its recognition multifactorial disease influenced genetic, environmental, behavioral determinants. Notably, escalating prevalence of earlier onset younger populations have intensified urgency develop novel therapeutic agents simultaneously ensure efficacy safety. This review aims elucidate pathophysiological mechanisms underlying obesity, analyze major complications—including type 2 diabetes mellitus (T2DM), cardiovascular diseases (CVD), non-alcoholic fatty liver (NAFLD), obesity-related respiratory disorders, nephropathy (ORN), musculoskeletal impairments, malignancies, psychological comorbidities—and critically evaluate current anti-obesity strategies. Particular emphasis placed on emerging pharmacological interventions, exemplified plant-derived natural compounds such berberine (BBR), with focus their molecular mechanisms, clinical efficacy, advantages. By integrating mechanistic insights evidence, this seeks provide innovative perspectives for developing safe, accessible, effective treatments.

Language: Английский

Citations

0