Reactive Oxygen Species-Responsive Polymer Drug Delivery System Targeted Oxidative Stressed Colon Cells to Ameliorate Colitis DOI

Wo-Qi Cai,

Wanqi Liang, Dong Li

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

Ulcerative colitis (UC) is a chronic inflammatory condition that imposes huge healthcare burden globally. The inflamed colon marked by an abundance of positively charged proteins, increased reactive oxygen species (ROS), disrupted intestinal barrier, and imbalanced gut microbiome. Leveraging these features, we designed negatively ROS-responsive nanocarrier using diselenide-bond-modified carboxymethyl cellulose (CMC) for the targeted delivery curcumin, natural ROS-scavenging antioxidant, to treat UC. design rationale encompasses three key aspects: (1) biocompatible biodegradable CMC matrix stabilizes curcumin during digestion; (2) diselenide bonds enable redox-triggered release at sites, ensuring precise therapeutic action; (3) negative charge nanoparticles enhances interactions with proteins in tissues, improving site-specific accumulation. Experimental validation confirmed principles, demonstrating resulting effectively preserve digestion sites. Additionally, interact folic acid receptors (positively proteins) are overexpressed on oxidatively stressed cell membranes, leading specific accumulation tissue. Subsequently, scavenge excessive ROS, restore barrier function, modulate microbiota. These synergistic actions collectively contribute significant mitigation symptoms both preventive regimens, suggesting promising alternative approach

Language: Английский

Assembly complexes of egg yolk low-density lipoprotein and Auricularia auricula polysaccharide stabilized high internal phase Pickering emulsions: Insights into the stabilization mechanism via fluid-fluid interaction between water and oil phases DOI
Yiding Yu, Shanglin Li, Weiyi Wang

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 305, P. 141027 - 141027

Published: Feb. 13, 2025

Language: Английский

Citations

0
Egg white-derived peptides co-assembly-reinforced zein/chondroitin sulfate nanoparticles for orally colon-targeted co-delivery of quercetin in colitis mitigation DOI

Sitong Ma,

Jingbo Liu, Yajuan Li

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106161 - 106161

Published: Feb. 1, 2025

Language: Английский

Citations

0
Exploring the impact of cationic polysaccharide concentration on the formation of high internal phase emulsion based on egg white proteins: A study on emulsion interfacial structure and co-delivery of epigallocatechin gallate/β-carotene DOI

Jingbo Liu,

Longxiang Li, Shanglin Li

et al.

Food Hydrocolloids, Journal Year: 2025, Volume and Issue: unknown, P. 111250 - 111250

Published: Feb. 1, 2025

Language: Английский

Citations

0
Fructose-modified chitosan-based coassemblies reinforced oral bioavailability of egg white oligopeptides and curcumin via glucose transporter 2-oriented transcytosis and preferable mucus permeation DOI
Jingbo Liu, Yang Liu, Shanglin Li

et al.

Food Research International, Journal Year: 2025, Volume and Issue: 206, P. 116065 - 116065

Published: Feb. 24, 2025

Language: Английский

Citations

0
Mung Bean Peptides Alleviate Dextran-Sulfate-Sodium-Induced Colitis Symptoms in Mice by Protecting the Intestinal Mechanical Barrier and Regulating Gut Microbiota DOI Creative Commons
Chong Xu, Jingjing Diao,

Yuchao Feng

et al.

Foods, Journal Year: 2025, Volume and Issue: 14(8), P. 1363 - 1363

Published: April 15, 2025

Ulcerative colitis (UC), an idiopathic and recurrent ailment, substantially influences a patient’s health. Mung bean peptides (MBPs) are bioactive substances derived from mung protein that possess notable anti-inflammatory properties. However, their efficacy underlying mechanisms in UC treatment remain unclear. In this study, the structural characteristics of MBPs were examined by determining various parameters, such as amino acid composition, molecular weight distribution, peptide sequences, thereby structurally demonstrating potential. The therapeutic effectiveness was evaluated assessing its influence on colon length, histological damage to colonic tissue, disease activity index mice suffering induced dextran sulfate sodium (DSS). Additionally, study explored potential mechanism action analyzing intestinal microbiota, inflammatory cytokines serum, tight junction (TJ) proteins tissue mice. results revealed significantly increased reduced damage, decreased with UC. restored barrier function upregulating expression ZO-1 claudin-1 within DSS-induced colitis, treating exerted effects downregulating amplification improving gut microbiota structure regulating immune-related signaling pathways. Therefore, there is experimental basis for use adjunctive therapy

Language: Английский

Citations

0
Reactive Oxygen Species-Responsive Polymer Drug Delivery System Targeted Oxidative Stressed Colon Cells to Ameliorate Colitis DOI

Wo-Qi Cai,

Wanqi Liang, Dong Li

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

Ulcerative colitis (UC) is a chronic inflammatory condition that imposes huge healthcare burden globally. The inflamed colon marked by an abundance of positively charged proteins, increased reactive oxygen species (ROS), disrupted intestinal barrier, and imbalanced gut microbiome. Leveraging these features, we designed negatively ROS-responsive nanocarrier using diselenide-bond-modified carboxymethyl cellulose (CMC) for the targeted delivery curcumin, natural ROS-scavenging antioxidant, to treat UC. design rationale encompasses three key aspects: (1) biocompatible biodegradable CMC matrix stabilizes curcumin during digestion; (2) diselenide bonds enable redox-triggered release at sites, ensuring precise therapeutic action; (3) negative charge nanoparticles enhances interactions with proteins in tissues, improving site-specific accumulation. Experimental validation confirmed principles, demonstrating resulting effectively preserve digestion sites. Additionally, interact folic acid receptors (positively proteins) are overexpressed on oxidatively stressed cell membranes, leading specific accumulation tissue. Subsequently, scavenge excessive ROS, restore barrier function, modulate microbiota. These synergistic actions collectively contribute significant mitigation symptoms both preventive regimens, suggesting promising alternative approach

Language: Английский

Citations

0