Camouflaged Nanozymes with Oxidation‐Promoting Activities Triggering Ferroptosis for Radio‐Immunotherapy DOI Creative Commons
Kun Qiao, Yongbiao Huang, Shipeng Ning

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 26, 2025

Abstract Radioresistance presents a substantial obstacle to achieving optimal therapeutic outcomes for breast cancer treatment. In this study, we develop cell membrane (CM) ‐ coated nanozyme system (MPPC@CM), specifically designed radioimmunotherapy address issue. This innovative involves the in situ reduction of platinum and palladium on mesoporous silica nanospheres, followed by functionalization with cinnamaldehyde via surface grafting. The CM coating endows enhanced tumor‐specific targeting capability due its homing properties. Upon uptake tumor cells, MPPC@CM catalytically generates O 2 from H , mitigating hypoxic microenvironment reducing radioresistance. intracellular glutathione depletion mediated Michael addition reactions concurrently disrupts endogenous antioxidant defenses against reactive oxygen species (ROS). redox imbalance is synergistically amplified through nanozyme‐mediated catalytic activities including both peroxidase‐like oxidase‐like functions. resultant massive ROS accumulation establishes self‐reinforcing oxidative cascade that ultimately induces functional inactivation peroxidase 4. immunosuppressive environment remodeled disturbance balance, which accelerates ferroptosis increases CD8 + T‐cell infiltration dendritic maturation. Overall, membrane‐camouflaged holds significant potential enhance efficacy radioimmunotherapy.

Language: Английский

Metal-organic coordinated self-assembled nanomedicine for enhanced cuproptosis-mediated chemo-photo-chemodynamic synergistic therapy of non-small cell lung cancer DOI
R.P. Liu,

Ruirui Zhao,

Zi-Wei Yu

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161305 - 161305

Published: March 1, 2025

Language: Английский

Citations

1
Camouflaged Nanozymes with Oxidation‐Promoting Activities Triggering Ferroptosis for Radio‐Immunotherapy DOI Creative Commons
Kun Qiao, Yongbiao Huang, Shipeng Ning

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 26, 2025

Abstract Radioresistance presents a substantial obstacle to achieving optimal therapeutic outcomes for breast cancer treatment. In this study, we develop cell membrane (CM) ‐ coated nanozyme system (MPPC@CM), specifically designed radioimmunotherapy address issue. This innovative involves the in situ reduction of platinum and palladium on mesoporous silica nanospheres, followed by functionalization with cinnamaldehyde via surface grafting. The CM coating endows enhanced tumor‐specific targeting capability due its homing properties. Upon uptake tumor cells, MPPC@CM catalytically generates O 2 from H , mitigating hypoxic microenvironment reducing radioresistance. intracellular glutathione depletion mediated Michael addition reactions concurrently disrupts endogenous antioxidant defenses against reactive oxygen species (ROS). redox imbalance is synergistically amplified through nanozyme‐mediated catalytic activities including both peroxidase‐like oxidase‐like functions. resultant massive ROS accumulation establishes self‐reinforcing oxidative cascade that ultimately induces functional inactivation peroxidase 4. immunosuppressive environment remodeled disturbance balance, which accelerates ferroptosis increases CD8 + T‐cell infiltration dendritic maturation. Overall, membrane‐camouflaged holds significant potential enhance efficacy radioimmunotherapy.

Language: Английский

Citations

0