Advancing Nanomaterial-Based Strategies for Alzheimer’s Disease: A Perspective DOI Creative Commons
Hong Zhou, Xiuhua Yin,

G. Y. Zhang

et al.

JACS Au, Journal Year: 2025, Volume and Issue: unknown

Published: March 31, 2025

Alzheimer's disease (AD) is a complex neurodegenerative disorder and the most common cause of dementia. By 2050, number AD cases projected to exceed 131 million, placing significant strain on healthcare systems economies worldwide. The pathogenesis multifactorial, involving hypotheses/mechanisms, such as amyloid-β (Aβ) plaques, tau protein hyperphosphorylation, cholinergic neuron damage, oxidative stress, inflammation. Despite extensive research, complexity these potentially entangled mechanisms has hindered development treatments that can reverse progression. Nanotechnology, leveraging unique physical, electrical, magnetic, optical properties nanomaterials, emerged promising approach for treatment. In this Perspective, we first outlined major current pathogenic hypotheses then reviewed recent advances in nanomaterials addressing hypotheses. We have also discussed challenges translating into clinical applications proposed future directions, particularly multifunctional multitarget enhance their therapeutic efficacy applicability

Language: Английский

Diagnosis of neurological and non-neurological disorders via bimodal/multimodal imaging with lanthanide based nanoparticles DOI
Anurag Gautam, Pragya Komal

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 532, P. 216527 - 216527

Published: Feb. 18, 2025

Language: Английский

Citations

0
Behavioral and pathological characteristics of 5xFAD female mice in the early stage DOI Creative Commons
Chenlu Zhu, Xuejiao Liu

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 26, 2025

Alzheimer's disease (AD) is a central nervous system degenerative with insidious onset and gradual development caused by selective progressive loss of neurons. The 5xFAD mouse relatively mature model AD. However, the behavioral research on female more focused changes late memory function, exploration its early pathological still incomplete. This aims to explore in emotional function (including anxiety depression), motor ability, amyloid plaques, glial cell response neurogenesis hippocampus mice stage, laying foundation for comprehensive mechanism results this study found that 4-month-old mainly showed decline without other dysfunction. Accompanied large amount protein plaques deposited hippocampus, it induced microglia astrocytes, decreased significantly age, especially mice, which resulted decrease number new may be an important reason stage.

Language: Английский

Citations

0
Competitive Electrochemical Immunosensor for Trace Phosphorylated Tau181 Analysis in Plasma: Toward Point-of-Care Technologies of Alzheimer’s Disease DOI

Chencheng Luo,

Xiaoyu Zhu,

Yizhi Zhang

et al.

Talanta, Journal Year: 2025, Volume and Issue: unknown, P. 128009 - 128009

Published: March 1, 2025

Language: Английский

Citations

0
Advancing Nanomaterial-Based Strategies for Alzheimer’s Disease: A Perspective DOI Creative Commons
Hong Zhou, Xiuhua Yin,

G. Y. Zhang

et al.

JACS Au, Journal Year: 2025, Volume and Issue: unknown

Published: March 31, 2025

Alzheimer's disease (AD) is a complex neurodegenerative disorder and the most common cause of dementia. By 2050, number AD cases projected to exceed 131 million, placing significant strain on healthcare systems economies worldwide. The pathogenesis multifactorial, involving hypotheses/mechanisms, such as amyloid-β (Aβ) plaques, tau protein hyperphosphorylation, cholinergic neuron damage, oxidative stress, inflammation. Despite extensive research, complexity these potentially entangled mechanisms has hindered development treatments that can reverse progression. Nanotechnology, leveraging unique physical, electrical, magnetic, optical properties nanomaterials, emerged promising approach for treatment. In this Perspective, we first outlined major current pathogenic hypotheses then reviewed recent advances in nanomaterials addressing hypotheses. We have also discussed challenges translating into clinical applications proposed future directions, particularly multifunctional multitarget enhance their therapeutic efficacy applicability

Language: Английский

Citations

0