Bacteriophages as Targeted Therapeutic Vehicles: Challenges and Opportunities DOI Creative Commons

Srividhya Venkataraman,

Mehdi Shahgolzari,

Afagh Yavari

et al.

Bioengineering, Journal Year: 2025, Volume and Issue: 12(5), P. 469 - 469

Published: April 29, 2025

Bacteriophages, with their distinctive ability to selectively target host bacteria, stand out as a compelling tool in the realm of drug and gene delivery. Their assembly from proteins nucleic acids, coupled modifiable biologically unique properties, enables them serve efficient safe delivery systems. Unlike conventional nanocarriers, which face limitations such non-specific targeting, cytotoxicity, reduced transfection efficiency vivo, engineered phages exhibit promising potential overcome these hurdles improve outcomes. This review highlights bacteriophage-based systems innovative for delivering therapeutic agents. It explores strategies engineering bacteriophage, categorizes principal types employed delivery, evaluates applications disease therapy. provides intriguing details use natural therapy diseases cancer, bacterial viral infections, veterinary diseases, neurological disorders, well phage display technology generating monoclonal antibodies against various human diseases. Additionally, CRISPR-Cas9 genetically is elucidated. Furthermore, it critical analysis challenges associated phage-based systems, offering insights overcoming obstacles. By showcasing advancements integration into nanotechnology, this study underscores revolutionize approaches inspire future innovations medicine.

Language: Английский

Bacteriophages as Targeted Therapeutic Vehicles: Challenges and Opportunities DOI Creative Commons

Srividhya Venkataraman,

Mehdi Shahgolzari,

Afagh Yavari

et al.

Bioengineering, Journal Year: 2025, Volume and Issue: 12(5), P. 469 - 469

Published: April 29, 2025

Bacteriophages, with their distinctive ability to selectively target host bacteria, stand out as a compelling tool in the realm of drug and gene delivery. Their assembly from proteins nucleic acids, coupled modifiable biologically unique properties, enables them serve efficient safe delivery systems. Unlike conventional nanocarriers, which face limitations such non-specific targeting, cytotoxicity, reduced transfection efficiency vivo, engineered phages exhibit promising potential overcome these hurdles improve outcomes. This review highlights bacteriophage-based systems innovative for delivering therapeutic agents. It explores strategies engineering bacteriophage, categorizes principal types employed delivery, evaluates applications disease therapy. provides intriguing details use natural therapy diseases cancer, bacterial viral infections, veterinary diseases, neurological disorders, well phage display technology generating monoclonal antibodies against various human diseases. Additionally, CRISPR-Cas9 genetically is elucidated. Furthermore, it critical analysis challenges associated phage-based systems, offering insights overcoming obstacles. By showcasing advancements integration into nanotechnology, this study underscores revolutionize approaches inspire future innovations medicine.

Language: Английский

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